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Surgery management for sporadic small (≤2 cm), non-functioning pancreatic neuroendocrine tumors: a consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET)

  • Authors:
    • Guang Yang
    • Meng Ji
    • Jie Chen
    • Rufu Chen
    • Ye Chen
    • Deliang Fu
    • Baohua Hou
    • Heguang Huang
    • Liming Jiang
    • Kaizhou Jin
    • Nengwen Ke
    • Ying Li
    • Yong Li
    • Houjie Liang
    • An'an Liu
    • Jie Luo
    • Quanxing Ni
    • Chengwei Shao
    • Boyong Shen
    • Weiqi Sheng
    • Bin Song
    • Jian Sun
    • Chunlu Tan
    • Huangying Tan
    • Qiyun Tang
    • Yingmei Tang
    • Xiaodong Tian
    • Jian Wang
    • Jie Wang
    • Wei Wang
    • Zheng Wu
    • Jin Xu
    • Qiang Yan
    • Ning Yang
    • Yinmo Yang
    • Xiaoyu Yin
    • Xianjun Yu
    • Chunhui Yuan
    • Shan Zeng
    • Guochao Zhang
    • Renchao Zhang
    • Zhiwei Zhou
    • Zhaohui Zhu
    • Chenghao Shao

  • View Affiliations

  • Published online on: December 29, 2016     https://doi.org/10.3892/ijo.2016.3826
  • Pages: 567-574
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Abstract

The incidence of small (≤2 cm), non-functioning pancreatic neuroendocrine tumors (NF-pNETs) increased in the last decades. Before making appropriate strategy for patients with NF-pNETs ≤2 cm, pathological confirmation is vital. Incidentally diagnosed, sporadic small NF-pNETs may bring aggressive behavior and poor prognosis, such as extrapancreatic extension, lymph nodal metastasis, distant metastasis and recurrence, even causing disease-related death. Understanding and formulating an appropriate strategy for the patients with sporadic small, non-functioning pancreatic neuroendocrine tumors have been controversial for some time. Although several studies have reported that patients with NF-pNETs ≤2 cm had less rate of malignant behavior compared with larger ones (>2 cm); and the surgery approach may leading to surgery-related pancreatic complications; but there is still a lack of level I evidence to convince surgeons to abandon all cases with sporadic small NF-pNETs. Based on an updated literature search and review, the members of the Chinese Study Group for Neuroendocrine Tumors (CSNET) from high-volume centers have reached a consensus on the issue of the management strategy for the sporadic small NF-pNETs. We recommend that, except for some selected patients with NF-pNETs <1 cm, incidentally discovered and unacceptable surgical risks, all others with NF-pNETs ≤2 cm should undergo tumor resection with lymph node dissection or at least lymph node sampling and careful postoperative surveillance.
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February-2017
Volume 50 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
Yang G, Ji M, Chen J, Chen R, Chen Y, Fu D, Hou B, Huang H, Jiang L, Jin K, Jin K, et al: Surgery management for sporadic small (≤2 cm), non-functioning pancreatic neuroendocrine tumors: a consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET). Int J Oncol 50: 567-574, 2017.
APA
Yang, G., Ji, M., Chen, J., Chen, R., Chen, Y., Fu, D. ... Shao, C. (2017). Surgery management for sporadic small (≤2 cm), non-functioning pancreatic neuroendocrine tumors: a consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET). International Journal of Oncology, 50, 567-574. https://doi.org/10.3892/ijo.2016.3826
MLA
Yang, G., Ji, M., Chen, J., Chen, R., Chen, Y., Fu, D., Hou, B., Huang, H., Jiang, L., Jin, K., Ke, N., Li, Y., Li, Y., Liang, H., Liu, A., Luo, J., Ni, Q., Shao, C., Shen, B., Sheng, W., Song, B., Sun, J., Tan, C., Tan, H., Tang, Q., Tang, Y., Tian, X., Wang, J., Wang, J., Wang, W., Wu, Z., Xu, J., Yan, Q., Yang, N., Yang, Y., Yin, X., Yu, X., Yuan, C., Zeng, S., Zhang, G., Zhang, R., Zhou, Z., Zhu, Z., Shao, C."Surgery management for sporadic small (≤2 cm), non-functioning pancreatic neuroendocrine tumors: a consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET)". International Journal of Oncology 50.2 (2017): 567-574.
Chicago
Yang, G., Ji, M., Chen, J., Chen, R., Chen, Y., Fu, D., Hou, B., Huang, H., Jiang, L., Jin, K., Ke, N., Li, Y., Li, Y., Liang, H., Liu, A., Luo, J., Ni, Q., Shao, C., Shen, B., Sheng, W., Song, B., Sun, J., Tan, C., Tan, H., Tang, Q., Tang, Y., Tian, X., Wang, J., Wang, J., Wang, W., Wu, Z., Xu, J., Yan, Q., Yang, N., Yang, Y., Yin, X., Yu, X., Yuan, C., Zeng, S., Zhang, G., Zhang, R., Zhou, Z., Zhu, Z., Shao, C."Surgery management for sporadic small (≤2 cm), non-functioning pancreatic neuroendocrine tumors: a consensus statement by the Chinese Study Group for Neuroendocrine Tumors (CSNET)". International Journal of Oncology 50, no. 2 (2017): 567-574. https://doi.org/10.3892/ijo.2016.3826