Open Access

VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland

  • Authors:
    • Syed A. Hussain
    • Jawaher Ansari
    • Robert Huddart
    • Derek G. Power
    • Jeanette Lyons
    • James Wylie
    • Maria Vilarino-Varlela
    • Nils O. Elander
    • Rhona McMenemin
    • Lisa M. Pickering
    • Guy Faust
    • Seema Chauhan
    • Richard J. Jackson
  • View Affiliations

  • Published online on: January 13, 2017     https://doi.org/10.3892/ijo.2017.3847
  • Pages: 768-772
  • Copyright: © Hussain et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

There is no standard of care in the UK or Ireland for second-line chemotherapy for patients with advanced transitional cell carcinoma (TCCU). Vinflunine is approved for TCCU patients who have failed a platinum-based regimen, and is standard of care in Europe but is not routinely available in the UK. Data were collected retrospectively on patients who received vinfluine as a second-line treatment. The aims were to document the toxicity and efficacy in a real life setting. Data were collected on 49 patients from 9 sites across the UK and Ireland [median age, 64 (IQR, 57-70) years, 33 males]. All patients had advanced metastatic TCCU. Thirteen patients had bone or liver metastases, 4 patients had PS 2 and 11 patients had HB <10. Median vinflunine administration was 3.5 cycles (range 1-18). Most common grade 3-4 toxicities were constipation (4 patients) and fatigue (3 patients). Partial response rate was 29% (14 PR, 11 SD, 19 PD, 4 NE, 1 not available). Median OS was 9.1 (6.0, 12.7) months. Results are consistent with real life data from Europe. Toxicity is further reduced with prophylactic laxative and oral antibiotics. Vinflunine is an efficient and tolerable second line treatment in advanced TCCU.
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March-2017
Volume 50 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hussain SA, Ansari J, Huddart R, Power DG, Lyons J, Wylie J, Vilarino-Varlela M, Elander NO, McMenemin R, Pickering LM, Pickering LM, et al: VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland. Int J Oncol 50: 768-772, 2017.
APA
Hussain, S.A., Ansari, J., Huddart, R., Power, D.G., Lyons, J., Wylie, J. ... Jackson, R.J. (2017). VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland. International Journal of Oncology, 50, 768-772. https://doi.org/10.3892/ijo.2017.3847
MLA
Hussain, S. A., Ansari, J., Huddart, R., Power, D. G., Lyons, J., Wylie, J., Vilarino-Varlela, M., Elander, N. O., McMenemin, R., Pickering, L. M., Faust, G., Chauhan, S., Jackson, R. J."VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland". International Journal of Oncology 50.3 (2017): 768-772.
Chicago
Hussain, S. A., Ansari, J., Huddart, R., Power, D. G., Lyons, J., Wylie, J., Vilarino-Varlela, M., Elander, N. O., McMenemin, R., Pickering, L. M., Faust, G., Chauhan, S., Jackson, R. J."VICTOR: Vinflunine in advanced metastatic transitional cell carcinoma of the urothelium: A retrospective analysis of the use of vinflunine in multi-centre real life setting as second line chemotherapy through Free of Charge Programme for patients in the UK and Ireland". International Journal of Oncology 50, no. 3 (2017): 768-772. https://doi.org/10.3892/ijo.2017.3847