Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells

  • Authors:
    • Lian Hui
    • Jingru Zhang
    • Xiaoxu Ding
    • Xing Guo
    • Xuejun Jiang
  • View Affiliations

  • Published online on: February 15, 2017     https://doi.org/10.3892/ijo.2017.3877
  • Pages: 1439-1447
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Abstract

Increasing evidence shows that matrix stiffness plays a critical role in affecting the phenotype and behavior of tumor cells. We report that matrix stiffness significantly regulated the proliferation and chemotherapeutic response of Hep-2 cells. Increasing substrate stiffness promotes the proliferation of Hep-2 cells. When cultured on soft gels, Hep-2 cells expressed higher level of stem cell markers. Following treatment with cisplatin or 5-FU, we observed reduced apoptosis in Hep-2 cells cultured on soft supports. Sox2 is essential for the chemoresistance of Hep-2 cells cultured in soft stiffness. Our results demonstrated that Sox2 promotes chemoresistance of Hep-2 cells in soft stiffness via upregulating the expression of ABCG2. Our findings will provide a new platform for the future design of anticancer drugs based on the biophysical properties of the tumor site.
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April-2017
Volume 50 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hui L, Zhang J, Ding X, Guo X and Jiang X: Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells. Int J Oncol 50: 1439-1447, 2017
APA
Hui, L., Zhang, J., Ding, X., Guo, X., & Jiang, X. (2017). Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells. International Journal of Oncology, 50, 1439-1447. https://doi.org/10.3892/ijo.2017.3877
MLA
Hui, L., Zhang, J., Ding, X., Guo, X., Jiang, X."Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells". International Journal of Oncology 50.4 (2017): 1439-1447.
Chicago
Hui, L., Zhang, J., Ding, X., Guo, X., Jiang, X."Matrix stiffness regulates the proliferation, stemness and chemoresistance of laryngeal squamous cancer cells". International Journal of Oncology 50, no. 4 (2017): 1439-1447. https://doi.org/10.3892/ijo.2017.3877