Oncogenic function and prognostic significance of Abelson interactor 1 in hepatocellular carcinoma

  • Authors:
    • Ji-Long Wang
    • Ting-Ting Yan
    • Chen Long
    • Wen-Wu Cai
  • View Affiliations

  • Published online on: March 20, 2017     https://doi.org/10.3892/ijo.2017.3920
  • Pages: 1889-1898
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Abstract

Aberrant expression of Abelson interactor 1 (ABI1) has been reported in multiple cancers. However, its clinical significance and potential biological roles in hepatocellular carcinoma (HCC) have not been fully elucidated. In this study, we found that ABI1 was obviously upregulated in HCC tissues compared with non-tumor tissues. Moreover, high ABI1 expression was significantly correlated with tumor size (P=0.041), tumor number (P<0.001), tumor encapsulation (P<0.001) and BCLC stage (P=0.010). Importantly, Kaplan-Meier survival analysis showed that increased ABI1 expression predicted shorter overall survival time (P<0.001) and a higher tendency of tumor recurrence (P=0.001) in HCC patients. Multivariate Cox regression analysis further confirmed high ABI1 expression was an independent predictor for both overall survival (HR=1.795, P=0.025) and early recurrence (HR=1.893, P=0.012) after surgical resection. Furthermore, in vitro studies indicated that overexpression of ABI1 induced an increase in cell proliferation, migration and invasion of HCC cells, whereas knockdown of ABI1 did the opposite. Xenograft mouse models verified the promoting effects of ABI1 on HCC growth and lung metastasis in vivo. Collectively, our findings indicated that ABI1 contributes to the development and progression of HCC as an oncogene and may serve as a valuable prognostic marker for HCC patients.
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May-2017
Volume 50 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wang J, Yan T, Long C and Cai W: Oncogenic function and prognostic significance of Abelson interactor 1 in hepatocellular carcinoma. Int J Oncol 50: 1889-1898, 2017.
APA
Wang, J., Yan, T., Long, C., & Cai, W. (2017). Oncogenic function and prognostic significance of Abelson interactor 1 in hepatocellular carcinoma. International Journal of Oncology, 50, 1889-1898. https://doi.org/10.3892/ijo.2017.3920
MLA
Wang, J., Yan, T., Long, C., Cai, W."Oncogenic function and prognostic significance of Abelson interactor 1 in hepatocellular carcinoma". International Journal of Oncology 50.5 (2017): 1889-1898.
Chicago
Wang, J., Yan, T., Long, C., Cai, W."Oncogenic function and prognostic significance of Abelson interactor 1 in hepatocellular carcinoma". International Journal of Oncology 50, no. 5 (2017): 1889-1898. https://doi.org/10.3892/ijo.2017.3920