A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism

  • Authors:
    • Wensheng Liu
    • Bo Zhang
    • Qiangsheng Hu
    • Yi Qin
    • Wenyan Xu
    • Si Shi
    • Chen Liang
    • Qingcai Meng
    • Jinfeng Xiang
    • Dingkong Liang
    • Shunrong Ji
    • Jiang Liu
    • Pengfei Hu
    • Liang Liu
    • Chen Liu
    • Jiang Long
    • Quanxing Ni
    • Xianjun Yu
    • Jin Xu
  • View Affiliations

  • Published online on: March 28, 2017     https://doi.org/10.3892/ijo.2017.3938
  • Pages: 1792-1800
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

N-myc downstream-regulated gene 1 (NDRG1) is known as tumor/metastasis suppressor in a variety of cancers including pancreas, being involved in angiogenesis, cancer growth and metastasis. However, the precise molecular mechanism how NDRG1 exerts its inhibitory function in pancreatic cancer remains unclear. In this investigation, we demonstrated that K-Ras plays a vital role in modulating NDRG1 protein level in PDAC cancer cells in vitro, which is mediated through ERK signaling. Noteworthy, K-Ras downstream Akt/mTOR signaling is inhibited upon NDRG1 overexpression, resulting in decease of HIF1α level. Moreover, NDRG1 has a unique role in modulating cancer metabolism of pancreatic ductal adenocarcinoma (PDAC). The mechanism accounting for NDRG1 in modulating aerobic glycolysis, at least partly, relied on its regulation of glycolysis genes including GLUT1, HK2, LDHA and PDK1. Additionally, NDRG1 is shown to suppress the activity of HIF1α, which is responsible for regulation of glycolysis enzymes. The current study is the first to elucidate a unique facet of the potent tumor/metastasis suppressor NDRG1 in the regulation of PDAC glycolysis, leading to important insights into the mechanism by which NDRG1 exert inhibitory function in PDAC.
View Figures
View References

Related Articles

Journal Cover

May-2017
Volume 50 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Liang D, et al: A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism. Int J Oncol 50: 1792-1800, 2017.
APA
Liu, W., Zhang, B., Hu, Q., Qin, Y., Xu, W., Shi, S. ... Xu, J. (2017). A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism. International Journal of Oncology, 50, 1792-1800. https://doi.org/10.3892/ijo.2017.3938
MLA
Liu, W., Zhang, B., Hu, Q., Qin, Y., Xu, W., Shi, S., Liang, C., Meng, Q., Xiang, J., Liang, D., Ji, S., Liu, J., Hu, P., Liu, L., Liu, C., Long, J., Ni, Q., Yu, X., Xu, J."A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism". International Journal of Oncology 50.5 (2017): 1792-1800.
Chicago
Liu, W., Zhang, B., Hu, Q., Qin, Y., Xu, W., Shi, S., Liang, C., Meng, Q., Xiang, J., Liang, D., Ji, S., Liu, J., Hu, P., Liu, L., Liu, C., Long, J., Ni, Q., Yu, X., Xu, J."A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism". International Journal of Oncology 50, no. 5 (2017): 1792-1800. https://doi.org/10.3892/ijo.2017.3938