Open Access

CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway

  • Authors:
    • Feng Li
    • Chuanxi Tang
    • Dan Jin
    • Li Guan
    • Yue Wu
    • Xinfeng Liu
    • Xiuxiang Wu
    • Qing Yun Wu
    • Dianshuai Gao
  • View Affiliations

  • Published online on: May 17, 2017     https://doi.org/10.3892/ijo.2017.4009
  • Pages: 115-127
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

CUEDC2, a CUE domain containing 2 protein, plays critical roles in many biological processes, such as cell cycle, inflammation and tumorigenesis. However, whether CUEDC2 was involved in tumorigenesis of glioma and the possible mechanism remains to be elucidated. In the present study, our results implied that the expression of CUEDC2 was lower in the glioma tissue and glioma cell lines than that of normal tissue and asctrocyte cells. Downregulation of endogenous CUEDC2 in glioma U251 cell lines by RNAi promoted the tumor cells proliferation, migration, invasion and glioma neurosphere formation, while, overexpression of CUEDC2 showed the opposite effect. Further studies showed that overexpression of CUEDC2 suppressed the activation and nuclear translocation of phosphorylated-STAT3 (p-STAT3) but the level of p-STAT3 increased after interfering with the expression of CUEDC2. Moreover, CUEDC2 expression has an inhibitory effect on the activation of NF-κB. Thus, our studies suggested that the decreased expression of CUEDC2 in glioma led to the activation of transcription factor STAT3 and NF-κB signaling pathway which may be related to the tumorigenicity in glioma.
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July-2017
Volume 51 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Li F, Tang C, Jin D, Guan L, Wu Y, Liu X, Wu X, Wu QY and Gao D: CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway. Int J Oncol 51: 115-127, 2017.
APA
Li, F., Tang, C., Jin, D., Guan, L., Wu, Y., Liu, X. ... Gao, D. (2017). CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway. International Journal of Oncology, 51, 115-127. https://doi.org/10.3892/ijo.2017.4009
MLA
Li, F., Tang, C., Jin, D., Guan, L., Wu, Y., Liu, X., Wu, X., Wu, Q. Y., Gao, D."CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway". International Journal of Oncology 51.1 (2017): 115-127.
Chicago
Li, F., Tang, C., Jin, D., Guan, L., Wu, Y., Liu, X., Wu, X., Wu, Q. Y., Gao, D."CUEDC2 suppresses glioma tumorigenicity by inhibiting the activation of STAT3 and NF-κB signaling pathway". International Journal of Oncology 51, no. 1 (2017): 115-127. https://doi.org/10.3892/ijo.2017.4009