1
|
Greenberg PL, Stone RM, Al-Kali A, Barta
SK, Bejar R, Bennett JM, Carraway H, De Castro CM, Deeg HJ, DeZern
AE, et al: Myelodysplastic syndromes, version 2.2017, NCCN Clinical
Practice Guidelines in Oncology. J Natl Compr Canc Netw. 15:60–87.
2017. View Article : Google Scholar : PubMed/NCBI
|
2
|
Li N, Chen Q, Gu J, Li S, Zhao G, Wang W,
Wang Z and Wang X: Synergistic inhibitory effects of deferasirox in
combination with decitabine on leukemia cell lines SKM-1, THP-1,
and K-562. Oncotarget. 8:36517–36530. 2017.PubMed/NCBI
|
3
|
Rose C, Brechignac S, Vassilief D, Pascal
L, Stamatoullas A, Guerci A, Larbaa D, Dreyfus F, Beyne-Rauzy O,
Chaury MP, et al GFM (Groupe Francophone des Myélodysplasies): Does
iron chelation therapy improve survival in regularly transfused
lower risk MDS patients? A multicenter study by the GFM (Groupe
Francophone des Myélodysplasies). Leuk Res. 34:864–870. 2010.
View Article : Google Scholar : PubMed/NCBI
|
4
|
Schanz J, Tüchler H, Solé F, Mallo M, Luño
E, Cervera J, Granada I, Hildebrandt B, Slovak ML, Ohyashiki K, et
al: New comprehensive cytogenetic scoring system for primary
myelodysplastic syndromes (MDS) and oligoblastic acute myeloid
leukemia after MDS derived from an international database merge. J
Clin Oncol. 30:820–829. 2012. View Article : Google Scholar : PubMed/NCBI
|
5
|
Ahmad A and Iqbal MA: Significance of
genome-wide analysis of copy number alterations and UPD in
myelodysplastic syndromes using combined CGH - SNP arrays. Curr Med
Chem. 19:3739–3747. 2012. View Article : Google Scholar : PubMed/NCBI
|
6
|
Pfeifer D, Pantic M, Skatulla I, Rawluk J,
Kreutz C, Martens UM, Fisch P, Timmer J and Veelken H: Genome-wide
analysis of DNA copy number changes and LOH in CLL using
high-density SNP arrays. Blood. 109:1202–1210. 2007. View Article : Google Scholar
|
7
|
Wang L, Fidler C, Nadig N, Giagounidis A,
Della Porta MG, Malcovati L, Killick S, Gattermann N, Aul C,
Boultwood J, et al: Genome-wide analysis of copy number changes and
loss of heterozygosity in myelodysplastic syndrome with del(5q)
using high-density single nucleotide polymorphism arrays.
Haematologica. 93:994–1000. 2008. View Article : Google Scholar : PubMed/NCBI
|
8
|
Bis DM, Schüle R, Reichbauer J, Synofzik
M, Rattay TW, Soehn A, de Jonghe P, Schöls L and Züchner S:
Uniparental disomy determined by whole-exome sequencing in a
spectrum of rare motoneuron diseases and ataxias. Mol Genet Genomic
Med. 5:280–286. 2017. View
Article : Google Scholar : PubMed/NCBI
|
9
|
Steinbach D, Schramm A, Eggert A, Onda M,
Dawczynski K, Rump A, Pastan I, Wittig S, Pfaffendorf N, Voigt A,
et al: Identification of a set of seven genes for the monitoring of
minimal residual disease in pediatric acute myeloid leukemia. Clin
Cancer Res. 12:2434–2441. 2006. View Article : Google Scholar : PubMed/NCBI
|
10
|
Steinbach D, Bader P, Willasch A,
Bartholomae S, Debatin KM, Zimmermann M, Creutzig U, Reinhardt D
and Gruhn B: Prospective validation of a new method of monitoring
minimal residual disease in childhood acute myelogenous leukemia.
Clin Cancer Res. 21:1353–1359. 2015. View Article : Google Scholar
|
11
|
Neilson LI, Schneider PA, Van Deerlin PG,
Kiriakidou M, Driscoll DA, Pellegrini MC, Millinder S, Yamamoto KK,
French CK and Strauss JF III: cDNA cloning and characterization of
a human sperm antigen (SPAG6) with homology to the product of the
Chlamydomonas PF16 locus. Genomics. 60:272–280. 1999. View Article : Google Scholar : PubMed/NCBI
|
12
|
Zhang Z, Jones BH, Tang W, Moss SB, Wei Z,
Ho C, Pollack M, Horowitz E, Bennett J, Baker ME and Strauss JF
3rd: Dissecting the axoneme interactome: The mammalian orthologue
of Chlamydomonas PF6 interacts with sperm-associated antigen 6, the
mammalian orthologue of Chlamydomonas PF16. Mol Cell Protezom.
4:914–923. 2005. View Article : Google Scholar
|
13
|
Sapiro R, Kostetskii I, Olds-Clarke P,
Gerton GL, Radice GL and Strauss JF III: Male infertility, impaired
sperm motility, and hydrocephalus in mice deficient in
sperm-associated antigen 6. Mol Cell Biol. 22:6298–6305. 2002.
View Article : Google Scholar : PubMed/NCBI
|
14
|
Lonergan KM, Chari R, Deleeuw RJ, Shadeo
A, Chi B, Tsao MS, Jones S, Marra M, Ling V, Ng R, et al:
Identification of novel lung genes in bronchial epithelium by
serial analysis of gene expression. Am J Respir Cell Mol Biol.
35:651–661. 2006. View Article : Google Scholar : PubMed/NCBI
|
15
|
Mulaw MA, Krause A, Deshpande AJ, Krause
LF, Rouhi A, La Starza R, Borkhardt A, Buske C, Mecucci C, Ludwig
WD, et al: CALM/AF10-positive leukemias show upregulation of genes
involved in chromatin assembly and DNA repair processes and of
genes adjacent to the breakpoint at 10p12. Leukemia. 26:1012–1019.
2012. View Article : Google Scholar
|
16
|
Siliņa K, Zayakin P, Kalniņa Z, Ivanova L,
Meistere I, Endzeliņš E, Abols A, Stengrēvics A, Leja M, Ducena K,
et al: Sperm-associated antigens as targets for cancer
immunotherapy: Expression pattern and humoral immune response in
cancer patients. J Immunother. 34:28–44. 2011. View Article : Google Scholar
|
17
|
Nakagawa T, Matozaki S, Murayama T,
Nishimura R, Tsutsumi M, Kawaguchi R, Yokoyama Y, Hikiji K, Isobe T
and Chihara K: Establishment of a leultaemic cell line from a
patient with acquisition of chromosomal abnormalities during
disease progression in myelodysplastic syndrome. Br J Haematol.
85:469–476. 1993. View Article : Google Scholar : PubMed/NCBI
|
18
|
Yang B, Wang L, Luo X, Chen L, Yang Z and
Liu L: SPAG6 silencing inhibits the growth of the malignant myeloid
cell lines SKM-1 and K562 via activating p53 and caspase
activation-dependent apoptosis. Int J Oncol. 46:649–656. 2015.
View Article : Google Scholar
|
19
|
Li X, Yang B, Wang L, Chen L, Luo X and
Liu L: SPAG6 regulates cell apoptosis through the TRAIL signal
pathway in myelodysplastic syndromes. Oncol Rep. 37:2839–2846.
2017. View Article : Google Scholar : PubMed/NCBI
|
20
|
Di Cristofano A and Pandolfi PP: The
multiple roles of PTEN in tumor suppression. Cell. 100:387–390.
2000. View Article : Google Scholar : PubMed/NCBI
|
21
|
Stambolic V, Suzuki A, de la Pompa JL,
Brothers GM, Mirtsos C, Sasaki T, Ruland J, Penninger JM,
Siderovski DP and Mak TW: Negative regulation of PKB/Akt-dependent
cell survival by the tumor suppressor PTEN. Cell. 95:29–39. 1998.
View Article : Google Scholar : PubMed/NCBI
|
22
|
Zhao L, Shan Y, Liu B, Li Y and Jia L:
Functional screen analysis reveals miR-3142 as central regulator in
chemoresistance and proliferation through activation of the
PTEN-AKT pathway in CML. Cell Death Dis. 8:e28302017. View Article : Google Scholar : PubMed/NCBI
|
23
|
Scherr M and Eder M; M SMaE: Gene transfer
into hematopoietic stem cells using lentiviral vectors. Curr Gene
Ther. 2:45–55. 2002. View Article : Google Scholar : PubMed/NCBI
|
24
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
25
|
Storti P, Donofrio G, Colla S, Airoldi I,
Bolzoni M, Agnelli L, Abeltino M, Todoerti K, Lazzaretti M, Mancini
C, et al: HOXB7 expression by myeloma cells regulates their
pro-angiogenic properties in multiple myeloma patients. Leukemia.
25:527–537. 2011. View Article : Google Scholar
|
26
|
Song MS, Salmena L and Pandolfi PP: The
functions and regulation of the PTEN tumour suppressor. Nat Rev Mol
Cell Biol. 13:283–296. 2012. View
Article : Google Scholar : PubMed/NCBI
|
27
|
Yang JY and Widmann C: The RasGAP
N-terminal fragment generated by caspase cleavage protects cells in
a Ras/PI3K/Akt-dependent manner that does not rely on NFkappa B
activation. J Biol Chem. 277:14641–14646. 2002. View Article : Google Scholar : PubMed/NCBI
|
28
|
Rhee I, Bachman KE, Park BH, Jair KW, Yen
RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, et al:
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells.
Nature. 416:552–556. 2002. View
Article : Google Scholar : PubMed/NCBI
|
29
|
Tsoplou P, Kouraklis-Symeonidis A,
Thanopoulou E, Zikos P, Orphanos V and Zoumbos NC: Apoptosis in
patients with myelodysplastic syndromes: Differential involvement
of marrow cells in 'good' versus 'poor' prognosis patients and
correlation with apoptosis-related genes. Leukemia. 13:1554–1563.
1999. View Article : Google Scholar : PubMed/NCBI
|
30
|
Parker JE and Mufti GJ: Excessive
apoptosis in low risk myelodysplastic syndromes (MDS). Leuk
Lymphoma. 40:1–24. 2000. View Article : Google Scholar
|
31
|
Kerbauy DB and Deeg HJ: Apoptosis and
antiapoptotic mechanisms in the progression of myelodysplastic
syndrome. Exp Hematol. 35:1739–1746. 2007. View Article : Google Scholar : PubMed/NCBI
|
32
|
Rodriguez M, Siwko S, Zeng L, Li J, Yi Z
and Liu M: Prostate-specific G-protein-coupled receptor
collaborates with loss of PTEN to promote prostate cancer
progression. Oncogene. 35:1153–1162. 2016. View Article : Google Scholar
|
33
|
Schöndorf T, Göhring UJ, Roth G, Middel I,
Becker M, Moser N, Valter MM and Hoopmann M: Time to progression is
dependent on the expression of the tumour suppressor PTEN in
ovarian cancer patients. Eur J Clin Invest. 33:256–260. 2003.
View Article : Google Scholar : PubMed/NCBI
|
34
|
Tsutsui S, Inoue H, Yasuda K, Suzuki K,
Higashi H, Era S and Mori M: Reduced expression of PTEN protein and
its prognostic implications in invasive ductal carcinoma of the
breast. Oncology. 68:398–404. 2005. View Article : Google Scholar : PubMed/NCBI
|
35
|
Nyåkern M, Tazzari PL, Finelli C, Bosi C,
Follo MY, Grafone T, Piccaluga PP, Martinelli G, Cocco L and
Martelli AM: Frequent elevation of Akt kinase phosphorylation in
blood marrow and peripheral blood mononuclear cells from high-risk
myelodysplastic syndrome patients. Leukemia. 20:230–238. 2006.
View Article : Google Scholar
|
36
|
Igney FH and Krammer PH: Death and
anti-death: Tumour resistance to apoptosis. Nat Rev Cancer.
2:277–288. 2002. View
Article : Google Scholar : PubMed/NCBI
|
37
|
Kim AH, Khursigara G, Sun X, Franke TF and
Chao MV: Akt phosphorylates and negatively regulates apoptosis
signal-regulating kinase 1. Mol Cell Biol. 21:893–901. 2001.
View Article : Google Scholar : PubMed/NCBI
|
38
|
Hu X, Yan R, Cheng X, Song L, Zhang W, Li
K and Zhao S: The function of sperm-associated antigen 6 in
neuronal proliferation and differentiation. J Mol Histol.
47:531–540. 2016. View Article : Google Scholar : PubMed/NCBI
|
39
|
Lee DW, Futami M, Carroll M, Feng Y, Wang
Z, Fernandez M, Whichard Z, Chen Y, Kornblau S, Shpall EJ, et al:
Loss of SHIP-1 protein expression in high-risk myelodysplastic
syndromes is associated with miR-210 and miR-155. Oncogene.
31:4085–4094. 2012. View Article : Google Scholar
|
40
|
Shu Y, Zhou X, Qi X, Liu S, Li K, Tan J,
Liu Z, Yu J, Zhang P and Zou L: β-Arrestin1 promotes the
self-renewal of the leukemia-initiating cell-enriched subpopulation
in B-lineage acute lymphoblastic leukemia related to DNMT1
activity. Cancer Lett. 357:170–178. 2015. View Article : Google Scholar
|
41
|
Altenberger C, Heller G, Ziegler B,
Tomasich E, Marhold M, Topakian T, Müllauer L, Heffeter P, Lang G,
End-Pfützenreuter A, et al: SPAG6 and L1TD1 are transcriptionally
regulated by DNA methylation in non-small cell lung cancers. Mol
Cancer. 16:12017. View Article : Google Scholar : PubMed/NCBI
|
42
|
Fuks F, Burgers WA, Brehm A, Hughes-Davies
L and Kouzarides T: DNA methyltransferase Dnmt1 associates with
histone deacetylase activity. Nat Genet. 24:88–91. 2000. View Article : Google Scholar
|
43
|
Hermann A, Gowher H and Jeltsch A:
Biochemistry and biology of mammalian DNA methyltransferases. Cell
Mol Life Sci. 61:2571–2587. 2004. View Article : Google Scholar : PubMed/NCBI
|