Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review)

  • Authors:
    • Etel R.P. Gimba
    • Mariana C.M. Brum
    • Gabriela Nestal De Moraes
  • View Affiliations

  • Published online on: December 6, 2018     https://doi.org/10.3892/ijo.2018.4656
  • Pages: 420-430
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Osteopontin (OPN) is a matricellular phosphoglycoprotein overexpressed in several tumor types and can activate several aspects of cancer progression in solid and non‑solid tumors. In the present review, the roles of OPN in mediating resistance to chemotherapy and radiotherapy and their main associated signaling pathways were summarized and discussed. Furthermore, it was detailed how OPN expression may be able to modulate resistance to these therapies by controlling epithelial cell plasticity, stemness potential and cell survival. Based on these data, the use of OPN and associated signaling was then proposed as potential molecular targets in order to sensitize resistant cells to main current therapeutic approaches. Finally, based on experimental evidence obtained by our group, the importance of investigating the specific roles OPN splicing isoforms have and how their properties may specifically control resistance to therapy was highlighted. These data elucidate a better understanding of how total OPN and their splicing isoforms, as well as their associated signaling, may contribute to main aspects of chemoresistance and radioresistance, such as those controlling cell survival, apoptosis, autophagy, stemness, epithelial cell plasticity and associated cell receptors.
View Figures
View References

Related Articles

Journal Cover

February-2019
Volume 54 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Gimba ER, Brum MC and Nestal De Moraes G: Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review). Int J Oncol 54: 420-430, 2019.
APA
Gimba, E.R., Brum, M.C., & Nestal De Moraes, G. (2019). Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review). International Journal of Oncology, 54, 420-430. https://doi.org/10.3892/ijo.2018.4656
MLA
Gimba, E. R., Brum, M. C., Nestal De Moraes, G."Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review)". International Journal of Oncology 54.2 (2019): 420-430.
Chicago
Gimba, E. R., Brum, M. C., Nestal De Moraes, G."Full-length osteopontin and its splice variants as modulators of chemoresistance and radioresistance (Review)". International Journal of Oncology 54, no. 2 (2019): 420-430. https://doi.org/10.3892/ijo.2018.4656