Bone morphogenetic proteins mediate crosstalk between cancer cells and the tumour microenvironment at primary tumours and metastases (Review)
- Authors:
- Zhiwei Sun
- Shuo Cai
- Catherine Zabkiewicz
- Chang Liu
- Lin Ye
-
Affiliations: VIP‑II Division of Medical Department, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education, Beijing), Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China, Cardiff China Medical Research Collaborative, Division of Cancer and Genetics, Cardiff University School of Medicine, Cardiff CF14 4XN, United Kingdom - Published online on: March 26, 2020 https://doi.org/10.3892/ijo.2020.5030
- Pages: 1335-1351
This article is mentioned in:
Abstract
Urist MR: Bone: Formation by autoinduction. Science. 150:893–899. 1965. View Article : Google Scholar : PubMed/NCBI | |
Ye L, Bokobza SM and Jiang WG: Bone morphogenetic proteins in development and progression of breast cancer and therapeutic potential (review). Int J Mol Med. 24:591–597. 2009. View Article : Google Scholar : PubMed/NCBI | |
Yang L, Meng F, Ma D, Xie W and Fang M: Bridging Decapentaplegic and Wingless signaling in Drosophila wings through repression of naked cuticle by Brinker. Development. 140:413–422. 2013. View Article : Google Scholar | |
Wu M, Chen G and Li YP: TGF-β and BMP signaling in osteoblast, skeletal development, and bone formation, homeostasis and disease. Bone Res. 4:160092016. View Article : Google Scholar | |
Willet SG and Mills JC: Stomach organ and cell lineage differentiation: From embryogenesis to adult homeostasis. Cell Mol Gastroenterol Hepatol. 2:546–559. 2016. View Article : Google Scholar : PubMed/NCBI | |
Todisco A: Regulation of gastric metaplasia, dysplasia, and neoplasia by bone morphogenetic protein signaling. Cell Mol Gastroenterol Hepatol. 3:339–347. 2017. View Article : Google Scholar : PubMed/NCBI | |
Tamada H, Kitazawa R, Gohji K and Kitazawa S: Epigenetic regulation of human bone morphogenetic protein 6 gene expression in prostate cancer. J Bone Miner Res. 16:487–496. 2001. View Article : Google Scholar : PubMed/NCBI | |
Guo D, Huang J and Gong J: Bone morphogenetic protein 4 (BMP4) is required for migration and invasion of breast cancer. Mol Cell Biochem. 363:179–190. 2012. View Article : Google Scholar | |
Ye L, Kynaston H and Jiang WG: Bone morphogenetic protein-10 suppresses the growth and aggressiveness of prostate cancer cells through a Smad independent pathway. J Urol. 181:2749–2759. 2009. View Article : Google Scholar : PubMed/NCBI | |
Cao Y, Slaney CY, Bidwell BN, Parker BS, Johnstone CN, Rautela J, Eckhardt BL and Anderson RL: BMP4 inhibits breast cancer metastasis by blocking myeloid-derived suppressor cell activity. Cancer Res. 74:5091–5102. 2014. View Article : Google Scholar : PubMed/NCBI | |
Raval P, Hsu HH, Schneider DJ, Sarras MP Jr, Masuhara K, Bonewald LF and Anderson HC: Expression of bone morphogenetic proteins by osteoinductive and non-osteoinductive human osteosarcoma cells. J Dent Res. 75:1518–1523. 1996. View Article : Google Scholar : PubMed/NCBI | |
Guo W, Gorlick R, Ladanyi M, Meyers PA, Huvos AG, Bertino JR and Healey JH: Expression of bone morphogenetic proteins and receptors in sarcomas. Clin Orthop Relat Res. 175–183. 1999. View Article : Google Scholar | |
Gao YH and Yang LY: In situ hybridization and immunohistochemical detection of bone morphogenetic protein genes in ameloblastomas. Zhonghua Yi Xue Za Zhi. 74:621–623. 6471994.In Chinese. | |
Kusafuka K, Luyten FP, De Bondt R, Hiraki Y, Shukunami C, Kayano T and Takemura T: Immunohistochemical evaluation of cartilage-derived morphogenic protein-1 and -2 in normal human salivary glands and pleomorphic adenomas. Virchows Arch. 442:482–490. 2003. View Article : Google Scholar : PubMed/NCBI | |
Hardwick JC, Kodach LL, Offerhaus GJ and van den Brink GR: Bone morphogenetic protein signalling in colorectal cancer. Nat Rev Cancer. 8:806–812. 2008. View Article : Google Scholar : PubMed/NCBI | |
Clement JH, Sanger J and Hoffken K: Expression of bone morphogenetic protein 6 in normal mammary tissue and breast cancer cell lines and its regulation by epidermal growth factor. Int J Cancer. 80:250–256. 1999. View Article : Google Scholar : PubMed/NCBI | |
Lehmann K, Janda E, Pierreux CE, Rytömaa M, Schulze A, McMahon M, Hill CS, Beug H and Downward J: Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: A mechanism leading to increased malignancy in epithelial cells. Genes Dev. 14:2610–2622. 2000. View Article : Google Scholar : PubMed/NCBI | |
Oft M, Peli J, Rudaz C, Schwarz H, Beug H and Reichmann E: TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev. 10:2462–2477. 1996. View Article : Google Scholar : PubMed/NCBI | |
Yue J and Mulder KM: Requirement of Ras/MAPK pathway activation by transforming growth factor beta for transforming growth factor beta 1 production in a Smad-dependent pathway. J Biol Chem. 275:30765–30773. 2000. View Article : Google Scholar : PubMed/NCBI | |
Wilkes MC, Mitchell H, Penheiter SG, Doré JJ, Suzuki K, Edens M, Sharma DK, Pagano RE and Leof EB: Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2. Cancer Res. 65:10431–10440. 2005. View Article : Google Scholar : PubMed/NCBI | |
Chen X, Liao J, Lu Y, Duan X and Sun W: Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1. Pathol Oncol Res. 17:257–261. 2011. View Article : Google Scholar | |
Wang SE, Shin I, Wu FY, Friedman DB and Arteaga CL: HER2/Neu (ErbB2) signaling to Rac1-Pak1 is temporally and spatially modulated by transforming growth factor beta. Cancer Res. 66:9591–9600. 2006. View Article : Google Scholar : PubMed/NCBI | |
Kang MH, Oh SC, Lee HJ, Kang HN, Kim JL, Kim JS and Yoo YA: Metastatic function of BMP-2 in gastric cancer cells: The role of PI3K/AKT, MAPK, the NF-κB pathway, and MMP-9 expression. Exp Cell Res. 317:1746–1762. 2011. View Article : Google Scholar : PubMed/NCBI | |
Zhang L, Ye Y, Long X, Xiao P, Ren X and Yu J: BMP signaling and its paradoxical effects in tumorigenesis and dissemination. Oncotarget. 7:78206–78218. 2016.PubMed/NCBI | |
Ye L, Mason MD and Jiang WG: Bone morphogenetic protein and bone metastasis, implication and therapeutic potential. Front Biosci (Landmark Ed). 16:865–897. 2011. View Article : Google Scholar | |
Nohe A, Hassel S, Ehrlich M, Neubauer F, Sebald W, Henis YI and Knaus P: The mode of bone morphogenetic protein (BMP) receptor oligomerization determines different BMP-2 signaling pathways. J Biol Chem. 277:5330–5338. 2002. View Article : Google Scholar | |
Nohe A, Keating E, Knaus P and Petersen NO: Signal transduction of bone morphogenetic protein receptors. Cellular Signal. 16:291–299. 2004. View Article : Google Scholar | |
Shi Y and Massague J: Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell. 113:685–700. 2003. View Article : Google Scholar : PubMed/NCBI | |
Ye L, Lewis-Russell JM, Davies G, Sanders AJ, Kynaston H and Jiang WG: Hepatocyte growth factor up-regulates the expression of the bone morphogenetic protein (BMP) receptors, BMPR-IB and BMPR-II, in human prostate cancer cells. Int J Oncol. 30:521–529. 2007.PubMed/NCBI | |
Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E and Matsumoto K: TAB1: An activator of the TAK1 MAPKKK in TGF-beta signal transduction. Science. 272:1179–1182. 1996. View Article : Google Scholar : PubMed/NCBI | |
Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H and Matsumoto K: XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J. 18:179–187. 1999. View Article : Google Scholar : PubMed/NCBI | |
Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E and Matsumoto K: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science. 270:2008–2011. 1995. View Article : Google Scholar : PubMed/NCBI | |
Kimura N, Matsuo R, Shibuya H, Nakashima K and Taga T: BMP2-induced apoptosis is mediated by activation of the TAK1-p38 kinase pathway that is negatively regulated by Smad6. J Biol Chem. 275:17647–17652. 2000. View Article : Google Scholar : PubMed/NCBI | |
Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, et al: A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem. 271:13675–13679. 1996. View Article : Google Scholar : PubMed/NCBI | |
Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H and Matsumoto K: The TAK1-NLK-MAPK-related pathway antagonizes signalling between beta-catenin and transcription factor TCF. Nature. 399:798–802. 1999. View Article : Google Scholar : PubMed/NCBI | |
Lee SW, Han SI, Kim HH and Lee ZH: TAK1-dependent activation of AP-1 and c-Jun N-terminal kinase by receptor activator of NF-kappaB. J Biochem Mol Biol. 35:371–376. 2002.PubMed/NCBI | |
Shirakabe K, Yamaguchi K, Shibuya H, Irie K, Matsuda S, Moriguchi T, Gotoh Y, Matsumoto K and Nishida E: TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase. J Biol Chem. 272:8141–8144. 1997. View Article : Google Scholar : PubMed/NCBI | |
Alarmo EL and Kallioniemi A: Bone morphogenetic proteins in breast cancer: Dual role in tumourigenesis? Endocr Relat Cancer. 17:R123–R139. 2010. View Article : Google Scholar : PubMed/NCBI | |
Gazzerro E, Gangji V and Canalis E: Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts. J Clin Invest. 102:2106–2114. 1998. View Article : Google Scholar : PubMed/NCBI | |
Onichtchouk D, Chen YG, Dosch R, Gawantka V, Delius H, Massagué J and Niehrs C: Silencing of TGF-beta signalling by the pseudoreceptor BAMBI. Nature. 401:480–485. 1999. View Article : Google Scholar : PubMed/NCBI | |
Grotewold L, Plum M, Dildrop R, Peters T and Ruther U: Bambi is coexpressed with Bmp-4 during mouse embryogenesis. Mech Dev. 100:327–330. 2001. View Article : Google Scholar : PubMed/NCBI | |
Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, et al: DRAGON, a bone morphogenetic protein co-receptor. J Biol Chem. 280:14122–14129. 2005. View Article : Google Scholar : PubMed/NCBI | |
Babitt JL, Zhang Y, Samad TA, Xia Y, Tang J, Campagna JA, Schneyer AL, Woolf CJ and Lin HY: Repulsive guidance molecule (RGMa), a DRAGON homologue, is a bone morphogenetic protein co-receptor. J Biol Chem. 280:29820–29827. 2005. View Article : Google Scholar : PubMed/NCBI | |
Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, Campagna JA, Chung RT, Schneyer AL, Woolf CJ, et al: Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet. 38:531–539. 2006. View Article : Google Scholar : PubMed/NCBI | |
Hayashi H, Abdollah S, Qiu Y, Cai J, Xu YY, Grinnell BW, Richardson MA, Topper JN, Gimbrone MA Jr, Wrana JL and Falb D: The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell. 89:1165–1173. 1997. View Article : Google Scholar : PubMed/NCBI | |
Takase M, Imamura T, Sampath TK, Takeda K, Ichijo H, Miyazono K and Kawabata M: Induction of Smad6 mRNA by bone morphogenetic proteins. Biochem Biophys Res Commun. 244:26–29. 1998. View Article : Google Scholar : PubMed/NCBI | |
Ishisaki A, Yamato K, Hashimoto S, Nakao A, Tamaki K, Nonaka K, ten Dijke P, Sugino H and Nishihara T: Differential inhibition of Smad6 and Smad7 on bone morphogenetic protein- and activin-mediated growth arrest and apoptosis in B cells. J Biol Chem. 274:13637–13642. 1999. View Article : Google Scholar : PubMed/NCBI | |
Feng XH, Lin X and Derynck R: Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-beta. EMBO J. 19:5178–5193. 2000. View Article : Google Scholar : PubMed/NCBI | |
Sano Y, Harada J, Tashiro S, Gotoh-Mandeville R, Maekawa T and Ishii S: ATF-2 is a common nuclear target of Smad and TAK1 pathways in transforming growth factor-beta signaling. J Biol Chem. 274:8949–8957. 1999. View Article : Google Scholar : PubMed/NCBI | |
Cordenonsi M, Montagner M, Adorno M, Zacchigna L, Martello G, Mamidi A, Soligo S, Dupont S and Piccolo S: Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation. Science. 315:840–843. 2007. View Article : Google Scholar : PubMed/NCBI | |
Miyazono K, Maeda S and Imamura T: Coordinate regulation of cell growth and differentiation by TGF-beta superfamily and Runx proteins. Oncogene. 23:4232–4237. 2004. View Article : Google Scholar : PubMed/NCBI | |
Germain S, Howell M, Esslemont GM and Hill CS: Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes Dev. 14:435–451. 2000.PubMed/NCBI | |
Miyazono K, ten Dijke P and Heldin CH: TGF-beta signaling by Smad proteins. Adv Immunol. 75:115–157. 2000. View Article : Google Scholar : PubMed/NCBI | |
Durand SH, Romeas A, Couble ML, Langlois D, Li JY, Magloire H, Bleicher F, Staquet MJ and Farges JC: Expression of the TGF-beta/BMP inhibitor EVI1 in human dental pulp cells. Arch Oral Biol. 52:712–719. 2007. View Article : Google Scholar : PubMed/NCBI | |
Luo K, Stroschein SL, Wang W, Chen D, Martens E, Zhou S and Zhou Q: The Ski oncoprotein interacts with the Smad proteins to repress TGFbeta signaling. Genes Dev. 13:2196–2206. 1999. View Article : Google Scholar : PubMed/NCBI | |
Spagnoli FM and Brivanlou AH: The Gata5 target, TGIF2, defines the pancreatic region by modulating BMP signals within the endoderm. Development. 135:451–461. 2008. View Article : Google Scholar | |
Wotton D and Massague J: Smad transcriptional corepressors in TGF beta family signaling. Curr Top Microbiol Immunol. 254:145–164. 2001.PubMed/NCBI | |
Zhu H, Kavsak P, Abdollah S, Wrana JL and Thomsen GH: A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 400:687–693. 1999. View Article : Google Scholar : PubMed/NCBI | |
Ye L, Lewis-Russell JM, Kyanaston HG and Jiang WG: Bone morphogenetic proteins and their receptor signaling in prostate cancer. Histol Histopathol. 22:1129–1147. 2007.PubMed/NCBI | |
Beck SE and Carethers JM: BMP suppresses PTEN expression via RAS/ERK signaling. Cancer Biol Ther. 6:1313–1317. 2007. View Article : Google Scholar : PubMed/NCBI | |
Duchartre Y, Kim YM and Kahn M: The Wnt signaling pathway in cancer. Crit Rev Oncol Hematol. 99:141–149. 2016. View Article : Google Scholar : PubMed/NCBI | |
Veeman MT, Axelrod JD and Moon RT: A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev Cell. 5:367–377. 2003. View Article : Google Scholar : PubMed/NCBI | |
Mosimann C, Hausmann G and Basler K: Beta-catenin hits chromatin: Regulation of Wnt target gene activation. Nat Rev Mol Cell Biol. 10:276–286. 2009. View Article : Google Scholar : PubMed/NCBI | |
Moon RT: Wnt/beta-catenin pathway. Sci STKE. 2005:cm12005.PubMed/NCBI | |
Teo JL and Kahn M: The Wnt signaling pathway in cellular proliferation and differentiation: A tale of two coactivators. Adv Drug Deliv Rev. 62:1149–1155. 2010. View Article : Google Scholar : PubMed/NCBI | |
Imai Y, Terai H, Nomura-Furuwatari C, Mizuno S, Matsumoto K, Nakamura T and Takaoka K: Hepatocyte growth factor contributes to fracture repair by upregulating the expression of BMP receptors. J Bone Miner Res. 20:1723–1730. 2005. View Article : Google Scholar : PubMed/NCBI | |
Zhen R, Yang J, Wang Y, Li Y, Chen B, Song Y, Ma G and Yang B: Hepatocyte growth factor improves bone regeneration via the bone morphogenetic protein2mediated NFκB signaling pathway. Mol Med Rep. 17:6045–6053. 2018.PubMed/NCBI | |
Luo K: Signaling cross talk between TGF-β/smad and other signaling pathways. Cold Spring Harb Perspect Biol. 9:pii: a022137. 2017. View Article : Google Scholar | |
Labbe E, Letamendia A and Attisano L: Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc Natl Acad Sci USA. 97:8358–8363. 2000. View Article : Google Scholar : PubMed/NCBI | |
Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H and Cho KW: Interaction between Wnt and TGF-beta signalling pathways during formation of Spemann's organizer. Nature. 403:781–785. 2000. View Article : Google Scholar : PubMed/NCBI | |
Hussein SM, Duff EK and Sirard C: Smad4 and beta-catenin co-activators functionally interact with lymphoid-enhancing factor to regulate graded expression of Msx2. J Biol Chem. 278:48805–48814. 2003. View Article : Google Scholar : PubMed/NCBI | |
Weng X, Zhang H, Ye J, Kan M, Liu F, Wang T, Deng J, Tan Y, He L and Liu Y: Hypermethylated Epidermal growth factor receptor (EGFR) promoter is associated with gastric cancer. Sci Rep. 5:101542015. View Article : Google Scholar : PubMed/NCBI | |
Lemmon MA and Schlessinger J: Cell signaling by receptor tyrosine kinases. Cell. 141:1117–1134. 2010. View Article : Google Scholar : PubMed/NCBI | |
Sigismund S, Avanzato D and Lanzetti L: Emerging functions of the EGFR in cancer. Mol Oncol. 12:3–20. 2018. View Article : Google Scholar : | |
de Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB and Lechleider RJ: Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev. 12:1587–1592. 1998. View Article : Google Scholar : PubMed/NCBI | |
Brown JD, DiChiara MR, Anderson KR, Gimbrone MA Jr and Topper JN: MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J Biol Chem. 274:8797–8805. 1999. View Article : Google Scholar : PubMed/NCBI | |
Ross KR, Corey DA, Dunn JM and Kelley TJ: SMAD3 expression is regulated by mitogen-activated protein kinase kinase-1 in epithelial and smooth muscle cells. Cell Signal. 19:923–931. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kretzschmar M, Doody J, Timokhina I and Massague J: A mechanism of repression of TGFbeta/ Smad signaling by oncogenic Ras. Genes Dev. 13:804–816. 1999. View Article : Google Scholar : PubMed/NCBI | |
Matsuura I, Wang G, He D and Liu F: Identification and characterization of ERK MAP kinase phosphorylation sites in Smad3. Biochemistry. 44:12546–12553. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kamaraju AK and Roberts AB: Role of Rho/ROCK and p38 MAP kinase pathways in transforming growth factor-beta-mediated Smad-dependent growth inhibition of human breast carcinoma cells in vivo. J Biol Chem. 280:1024–1036. 2005. View Article : Google Scholar | |
Guo X and Wang XF: Signaling cross-talk between TGF-beta/BMP and other pathways. Cell Res. 19:71–88. 2009. View Article : Google Scholar | |
Saha D, Datta PK and Beauchamp RD: Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4. J Biol Chem. 276:29531–29537. 2001. View Article : Google Scholar : PubMed/NCBI | |
Liang M, Liang YY, Wrighton K, Ungermannova D, Wang XP, Brunicardi FC, Liu X, Feng XH and Lin X: Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2. Mol Cell Biol. 24:7524–7537. 2004. View Article : Google Scholar : PubMed/NCBI | |
Brodin G, Ahgren A, ten Dijke P, Heldin CH and Heuchel R: Efficient TGF-beta induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter. J Biol Chem. 275:29023–29030. 2000. View Article : Google Scholar : PubMed/NCBI | |
Dowdy SC, Mariani A and Janknecht R: HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem. 278:44377–44384. 2003. View Article : Google Scholar : PubMed/NCBI | |
Uchida K, Suzuki H, Ohashi T, Nitta K, Yumura W and Nihei H: Involvement of MAP kinase cascades in Smad7 transcriptional regulation. Biochem Biophys Res Commun. 289:376–381. 2001. View Article : Google Scholar : PubMed/NCBI | |
Shaulian E and Karin M: AP-1 as a regulator of cell life and death. Nat Cell Biol. 4:E131–E136. 2002. View Article : Google Scholar : PubMed/NCBI | |
Hanafusa H, Ninomiya-Tsuji J, Masuyama N, Nishita M, Fujisawa J, Shibuya H, Matsumoto K and Nishida E: Involvement of the p38 mitogen-activated protein kinase pathway in transforming growth factor-beta-induced gene expression. J Biol Chem. 274:27161–27167. 1999. View Article : Google Scholar : PubMed/NCBI | |
Jin EJ, Lee SY, Choi YA, Jung JC, Bang OS and Kang SS: BMP-2-enhanced chondrogenesis involves p38 MAPK-mediated down-regulation of Wnt-7a pathway. Mol Cells. 22:353–359. 2006. | |
Thomas DA and Massague J: TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance. Cancer Cell. 8:369–380. 2005. View Article : Google Scholar : PubMed/NCBI | |
Monzen K, Hiroi Y, Kudoh S, Akazawa H, Oka T, Takimoto E, Hayashi D, Hosoda T, Kawabata M, Miyazono K, et al: Smads, TAK1, and their common target ATF-2 play a critical role in cardiomyocyte differentiation. J Cell Biol. 153:687–698. 2001. View Article : Google Scholar : PubMed/NCBI | |
Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL and Arteaga CL: Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem. 275:36803–36810. 2000. View Article : Google Scholar : PubMed/NCBI | |
Lamouille S and Derynck R: Cell size and invasion in TGF-beta-induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol. 178:437–451. 2007. View Article : Google Scholar : PubMed/NCBI | |
Ghosh-Choudhury N, Abboud SL, Nishimura R, Celeste A, Mahimainathan L and Choudhury GG: Requirement of BMP-2-induced phosphatidylinositol 3-kinase and Akt serine/threonine kinase in osteoblast differentiation and Smad-dependent BMP-2 gene transcription. J Biol Chem. 277:33361–33368. 2002. View Article : Google Scholar : PubMed/NCBI | |
He XC, Zhang J, Tong WG, Tawfik O, Ross J, Scoville DH, Tian Q, Zeng X, He X, Wiedemann LM, et al: BMP signaling inhibits intestinal stem cell self-renewal through suppression of Wnt-beta-catenin signaling. Nat Genet. 36:1117–1121. 2004. View Article : Google Scholar : PubMed/NCBI | |
Tian Q, He XC, Hood L and Li L: Bridging the BMP and Wnt pathways by PI3 kinase/Akt and 14-3-3zeta. Cell Cycle. 4:215–216. 2005. View Article : Google Scholar : PubMed/NCBI | |
Valderrama-Carvajal H, Cocolakis E, Lacerte A, Lee EH, Krystal G, Ali S and Lebrun JJ: Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP. Nat Cell Biol. 4:963–969. 2002. View Article : Google Scholar : PubMed/NCBI | |
Lu Z, Ghosh S, Wang Z and Hunter T: Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell. 4:499–515. 2003. View Article : Google Scholar | |
Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, et al: EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell. 36:547–559. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ye L, Lewis-Russell JM, Sanders AJ, Kynaston H and Jiang WG: HGF/SF up-regulates the expression of bone morphogenetic protein 7 in prostate cancer cells. Urol Oncol. 26:190–197. 2008. View Article : Google Scholar : PubMed/NCBI | |
Jiang WG, Martin TA, Parr C, Davies G, Matsumoto K and Nakamura T: Hepatocyte growth factor, its receptor, and their potential value in cancer therapies. Crit Rev Oncol Hematol. 53:35–69. 2005. View Article : Google Scholar | |
Davies G, Mason MD, Martin TA, Parr C, Watkins G, Lane J, Matsumoto K, Nakamura T and Jiang WG: The HGF/SF antagonist NK4 reverses fibroblast- and HGF-induced prostate tumor growth and angiogenesis in vivo. Int J Cancer. 106:348–354. 2003. View Article : Google Scholar : PubMed/NCBI | |
Martin TA, Parr C, Davies G, Watkins G, Lane J, Matsumoto K, Nakamura T, Mansel RE and Jiang WG: Growth and angio-genesis of human breast cancer in a nude mouse tumour model is reduced by NK4, a HGF/SF antagonist. Carcinogenesis. 24:1317–1323. 2003. View Article : Google Scholar : PubMed/NCBI | |
Tomioka D, Maehara N, Kuba K, Mizumoto K, Tanaka M, Matsumoto K and Nakamura T: Inhibition of growth, invasion, and metastasis of human pancreatic carcinoma cells by NK4 in an orthotopic mouse model. Cancer Res. 61:7518–7524. 2001.PubMed/NCBI | |
Abounader R, Ranganathan S, Lal B, Fielding K, Book A, Dietz H, Burger P and Laterra J: Reversion of human glioblastoma malignancy by U1 small nuclear RNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met expression. J Natl Cancer Inst. 91:1548–1556. 1999. View Article : Google Scholar : PubMed/NCBI | |
Jiang WG, Grimshaw D, Martin TA, Davies G, Parr C, Watkins G, Lane J, Abounader R, Laterra J and Mansel RE: Reduction of stromal fibroblast-induced mammary tumor growth, by retroviral ribozyme transgenes to hepatocyte growth factor/scatter factor and its receptor, c-MET. Clin Cancer Res. 9:4274–4281. 2003.PubMed/NCBI | |
Grenier A, Chollet-Martin S, Crestani B, Delarche C, El Benna J, Boutten A, Andrieu V, Durand G, Gougerot-Pocidalo MA, Aubier M and Dehoux M: Presence of a mobilizable intracellular pool of hepatocyte growth factor in human polymorphonuclear neutrophils. Blood. 99:2997–3004. 2002. View Article : Google Scholar : PubMed/NCBI | |
Taieb J, Delarche C, Paradis V, Mathurin P, Grenier A, Crestani B, Dehoux M, Thabut D, Gougerot-Pocidalo MA, Poynard T and Chollet-Martin S: Polymorphonuclear neutrophils are a source of hepatocyte growth factor in patients with severe alcoholic hepatitis. J Hepatol. 36:342–348. 2002. View Article : Google Scholar : PubMed/NCBI | |
Jaffre S, Dehoux M, Paugam C, Grenier A, Chollet-Martin S, Stern JB, Mantz J, Aubier M and Crestani B: Hepatocyte growth factor is produced by blood and alveolar neutrophils in acute respiratory failure. Am J Physiol Lung Cell Mol Physiol. 282:L310–L315. 2002. View Article : Google Scholar : PubMed/NCBI | |
Nakamura T, Nawa K and Ichihara A: Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem Biophys Res Commun. 122:1450–1459. 1984. View Article : Google Scholar : PubMed/NCBI | |
Nakashiro K, Hayashi Y and Oyasu R: Immunohistochemical expression of hepatocyte growth factor and c-Met/HGF receptor in benign and malignant human prostate tissue. Onco Rep. 10:1149–1153. 2003. | |
Nakashiro K, Hara S, Shinohara Y, Oyasu M, Kawamata H, Shintani S, Hamakawa H and Oyasu R: Phenotypic switch from paracrine to autocrine role of hepatocyte growth factor in an androgen-independent human prostatic carcinoma cell line, CWR22R. Am J Pathol. 165:533–540. 2004. View Article : Google Scholar : PubMed/NCBI | |
Janovska P and Bryja V: Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas. Br J Pharmacol. 174:4701–4715. 2017. View Article : Google Scholar : PubMed/NCBI | |
Hoppler S and Moon RT: BMP-2/-4 and Wnt-8 cooperatively pattern the Xenopus mesoderm. Mech Dev. 71:119–129. 1998. View Article : Google Scholar : PubMed/NCBI | |
Fuentealba LC, Eivers E, Ikeda A, Hurtado C, Kuroda H, Pera EM and De Robertis EM: Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal. Cell. 131:980–993. 2007. View Article : Google Scholar : PubMed/NCBI | |
Millet C, Yamashita M, Heller M, Yu LR, Veenstra TD and Zhang YE: A negative feedback control of transforming growth factor-beta signaling by glycogen synthase kinase 3-mediated Smad3 linker phosphorylation at Ser-204. J Biol Chem. 284:19808–19816. 2009. View Article : Google Scholar : PubMed/NCBI | |
Aragon E, Goerner N, Zaromytidou AI, Xi Q, Escobedo A, Massagué J and Macias MJ: A Smad action turnover switch operated by WW domain readers of a phosphoserine code. Genes Dev. 25:1275–1288. 2011. View Article : Google Scholar : PubMed/NCBI | |
Fei C, Li Z, Li C, Chen Y, Chen Z, He X, Mao L, Wang X, Zeng R and Li L: Smurf1-mediated Lys29-linked nonproteolytic polyubiquitination of axin negatively regulates Wnt/β-catenin signaling. Mol Cell Biol. 33:4095–4105. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kim S and Jho EH: The protein stability of Axin, a negative regulator of Wnt signaling, is regulated by Smad ubiquitination regulatory factor 2 (Smurf2). J Biol Chem. 285:36420–36426. 2010. View Article : Google Scholar : PubMed/NCBI | |
Jian H, Shen X, Liu I, Semenov M, He X and Wang XF: Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. Genes Dev. 20:666–674. 2006. View Article : Google Scholar : PubMed/NCBI | |
Aza-Blanc P and Kornberg TB: Ci: A complex transducer of the hedgehog signal. Trends Genet. 15:458–462. 1999. View Article : Google Scholar : PubMed/NCBI | |
Hepker J, Blackman RK and Holmgren R: Cubitus inter-ruptus is necessary but not sufficient for direct activation of a wing-specific decapentaplegic enhancer. Development. 126:3669–3677. 1999.PubMed/NCBI | |
Muller B and Basler K: The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites. Development. 127:2999–3007. 2000.PubMed/NCBI | |
Dennler S, Andre J, Alexaki I, Li A, Magnaldo T, ten Dijke P, Wang XJ, Verrecchia F and Mauviel A: Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res. 67:6981–6986. 2007. View Article : Google Scholar : PubMed/NCBI | |
Blokzijl A, Dahlqvist C, Reissmann E, Falk A, Moliner A, Lendahl U and Ibáñez CF: Cross-talk between the Notch and TGF-beta signaling pathways mediated by interaction of the Notch intracellular domain with Smad3. J Cell Biol. 163:723–728. 2003. View Article : Google Scholar : PubMed/NCBI | |
Asano N, Watanabe T, Kitani A, Fuss IJ and Strober W: Notch1 signaling and regulatory T cell function. J Immunol. 180:2796–2804. 2008. View Article : Google Scholar : PubMed/NCBI | |
Samon JB, Champhekar A, Minter LM, Telfer JC, Miele L, Fauq A, Das P, Golde TE and Osborne BA: Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood. 112:1813–1821. 2008. View Article : Google Scholar : PubMed/NCBI | |
Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P and Ray A: Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-beta. J Clin Invest. 116:996–1004. 2006. View Article : Google Scholar : PubMed/NCBI | |
Ulloa L, Doody J and Massague J: Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway. Nature. 397:710–713. 1999. View Article : Google Scholar : PubMed/NCBI | |
Ishida Y, Kondo T, Takayasu T, Iwakura Y and Mukaida N: The essential involvement of cross-talk between IFN-gamma and TGF-beta in the skin wound-healing process. J Immunol. 172:1848–1855. 2004. View Article : Google Scholar : PubMed/NCBI | |
Jenkins BJ, Grail D, Nheu T, Najdovska M, Wang B, Waring P, Inglese M, McLoughlin RM, Jones SA, Topley N, et al: Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling. Nat Med. 11:845–852. 2005. View Article : Google Scholar : PubMed/NCBI | |
Huang M, Sharma S, Zhu LX, Keane MP, Luo J, Zhang L, Burdick MD, Lin YQ, Dohadwala M, Gardner B, et al: IL-7 inhibits fibroblast TGF-beta production and signaling in pulmonary fibrosis. J Clin Invest. 109:931–937. 2002. View Article : Google Scholar : PubMed/NCBI | |
Letterio JJ and Roberts AB: Regulation of immune responses by TGF-beta. Annu Rev Immunol. 16:137–161. 1998. View Article : Google Scholar : PubMed/NCBI | |
Kang Y, Siegel PM, Shu W, Drobnjak M, Kakonen SM, Cordón-Cardo C, Guise TA and Massagué J: A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 3:537–549. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kang Y, He W, Tulley S, Gupta GP, Serganova I, Chen CR, Manova-Todorova K, Blasberg R, Gerald WL and Massagué J: Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA. 102:13909–13914. 2005. View Article : Google Scholar : PubMed/NCBI | |
Fong YC, Maa MC, Tsai FJ, Chen WC, Lin JG, Jeng LB, Yang RS, Fu WM and Tang CH: Osteoblast-derived TGF-beta1 stimulates IL-8 release through AP-1 and NF-kappaB in human cancer cells. J Bone Miner Res. 23:961–970. 2008. View Article : Google Scholar : PubMed/NCBI | |
Tseng JC, Chen HF and Wu KJ: A twist tale of cancer metastasis and tumor angiogenesis. Histol Histopathol. 30:1283–1294. 2015.PubMed/NCBI | |
Ye L and Jiang WG: Bone morphogenetic proteins in tumour associated angiogenesis and implication in cancer therapies. Cancer Lett. 380:586–597. 2016. View Article : Google Scholar | |
Goumans MJ, Valdimarsdottir G, Itoh S, Rosendahl A, Sideras P and ten Dijke P: Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors. EMBO J. 21:1743–1753. 2002. View Article : Google Scholar : PubMed/NCBI | |
Yamashita H, Shimizu A, Kato M, Nishitoh H, Ichijo H, Hanyu A, Morita I, Kimura M, Makishima F and Miyazono K: Growth/differentiation factor-5 induces angiogenesis in vivo. Exp Cell Res. 235:218–226. 1997. View Article : Google Scholar : PubMed/NCBI | |
Mori S, Yoshikawa H, Hashimoto J, Ueda T, Funai H, Kato M and Takaoka K: Antiangiogenic agent (TNP-470) inhibition of ectopic bone formation induced by bone morphogenetic protein-2. Bone. 22:99–105. 1998. View Article : Google Scholar : PubMed/NCBI | |
Yeh LC and Lee JC: Osteogenic protein-1 increases gene expression of vascular endothelial growth factor in primary cultures of fetal rat calvaria cells. Mol Cell Endocrinol. 153:113–124. 1999. View Article : Google Scholar : PubMed/NCBI | |
Glienke J, Schmitt AO, Pilarsky C, Hinzmann B, Weiss B, Rosenthal A and Thierauch KH: Differential gene expression by endothelial cells in distinct angiogenic states. Eur J Biochem. 267:2820–2830. 2000. View Article : Google Scholar : PubMed/NCBI | |
Langenfeld EM and Langenfeld J: Bone morphogenetic protein-2 stimulates angiogenesis in developing tumors. Molc Cancer Res. 2:141–149. 2004. | |
Finkenzeller G, Hager S and Stark GB: Effects of bone morpho-genetic protein 2 on human umbilical vein endothelial cells. Microvasc Res. 84:81–85. 2012. View Article : Google Scholar : PubMed/NCBI | |
Willette RN, Gu JL, Lysko PG, Anderson KM, Minehart H and Yue T: BMP-2 gene expression and effects on human vascular smooth muscle cells. J Vasc Re. 36:120–125. 1999. View Article : Google Scholar | |
Dorai H, Vukicevic S and Sampath TK: Bone morphogenetic protein-7 (osteogenic protein-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro. J Cell Physiol. 184:37–45. 2000. View Article : Google Scholar : PubMed/NCBI | |
Morrell NW, Yang X, Upton PD, Jourdan KB, Morgan N, Sheares KK and Trembath RC: Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation. 104:790–795. 2001. View Article : Google Scholar : PubMed/NCBI | |
David L, Mallet C, Mazerbourg S, Feige JJ and Bailly S: Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells. Blood. 109:1953–1961. 2007. View Article : Google Scholar | |
Regazzoni C, Winterhalter KH and Rohrer L: Type I collagen induces expression of bone morphogenetic protein receptor type II. Biochem Biophys Res Commun. 283:316–322. 2001. View Article : Google Scholar : PubMed/NCBI | |
Nakagawa T, Li JH, Garcia G, Mu W, Piek E, Böttinger EP, Chen Y, Zhu HJ, Kang DH, Schreiner GF, et al: TGF-beta induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways. Kidney Int. 66:605–613. 2004. View Article : Google Scholar : PubMed/NCBI | |
Han SU, Kim HT, Seong DH, Kim YS, Park YS, Bang YJ, Yang HK and Kim SJ: Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer. Oncogene. 23:1333–1341. 2004. View Article : Google Scholar | |
Dai J, Kitagawa Y, Zhang J, Yao Z, Mizokami A, Cheng S, Nör J, McCauley LK, Taichman RS and Keller ET: Vascular endothe-lial growth factor contributes to the prostate cancer-induced osteoblast differentiation mediated by bone morphogenetic protein. Cancer Res. 64:994–999. 2004. View Article : Google Scholar : PubMed/NCBI | |
Stabile H, Mitola S, Moroni E, Belleri M, Nicoli S, Coltrini D, Peri F, Pessi A, Orsatti L, Talamo F, et al: Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor. Blood. 109:1834–1840. 2007. View Article : Google Scholar | |
Akiyama I, Yoshino O, Osuga Y, Shi J, Harada M, Koga K, Hirota Y, Hirata T, Fujii T, Saito S and Kozuma S: Bone morphogenetic protein 7 increased vascular endothelial growth factor (VEGF)-a expression in human granulosa cells and VEGF receptor expression in endothelial cells. Reprod Sci. 21:477–482. 2014. View Article : Google Scholar : | |
Raida M, Clement JH, Leek RD, Ameri K, Bicknell R, Niederwieser D and Harris AL: Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. J Cancer Res Clin Oncol. 131:741–750. 2005. View Article : Google Scholar : PubMed/NCBI | |
Scharpfenecker M, van Dinther M, Liu Z, van Bezooijen RL, Zhao Q, Pukac L, Löwik CW and ten Dijke P: BMP-9 signals via ALK1 and inhibits bFGF-induced endothelial cell proliferation and VEGF-stimulated angiogenesis. J Cell Sci. 120:964–972. 2007. View Article : Google Scholar : PubMed/NCBI | |
Zabkiewicz C, Resaul J, Hargest R, Jiang WG and Ye L: Bone morphogenetic proteins, breast cancer, and bone metastases: Striking the right balance. Endocr Relat Cancer. 24:R349–R366. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ramoshebi LN and Ripamonti U: Osteogenic protein-1, a bone morphogenetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor-beta1. Anat Rec. 259:97–107. 2000. View Article : Google Scholar : PubMed/NCBI | |
Larue L and Bellacosa A: Epithelial-mesenchymal transition in development and cancer: Role of phosphatidylinositol 3' kinase/AKT pathways. Oncogene. 24:7443–7454. 2005. View Article : Google Scholar : PubMed/NCBI | |
Lamouille S, Xu J and Derynck R: Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 15:178–196. 2014. View Article : Google Scholar : PubMed/NCBI | |
Nakajima Y, Yamagishi T, Hokari S and Nakamura H: Mechanisms involved in valvuloseptal endocardial cushion formation in early cardiogenesis: Roles of transforming growth factor (TGF)-beta and bone morphogenetic protein (BMP). Anat Rec. 258:119–127. 2000. View Article : Google Scholar : PubMed/NCBI | |
Romano LA and Runyan RB: Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. Dev Biol. 223:91–102. 2000. View Article : Google Scholar : PubMed/NCBI | |
Yang S, Zhong C, Frenkel B, Reddi AH and Roy-Burman P: Diverse biological effect and Smad signaling of bone morpho-genetic protein 7 in prostate tumor cells. Cancer Res. 65:5769–5777. 2005. View Article : Google Scholar : PubMed/NCBI | |
Montesano R: Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth. Biochem Biophys Res Commun. 353:817–822. 2007. View Article : Google Scholar | |
Piek E, Moustakas A, Kurisaki A, Heldin CH and ten Dijke P: TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci. 112:4557–4568. 1999.PubMed/NCBI | |
Yang S, Du J, Wang Z, Yuan W, Qiao Y, Zhang M, Zhang J, Gao S, Yin J, Sun B and Zhu T: BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells. BMC Cancer. 7:2112007. View Article : Google Scholar : PubMed/NCBI | |
Clement JH, Raida M, Sanger J, Bicknell R, Liu J, Naumann A, Geyer A, Waldau A, Hortschansky P, Schmidt A, et al: Bone morphogenetic protein 2 (BMP-2) induces in vitro invasion and in vivo hormone independent growth of breast carcinoma cells. Int J Oncol. 27:401–407. 2005.PubMed/NCBI | |
Katsuno Y, Hanyu A, Kanda H, Ishikawa Y, Akiyama F, Iwase T, Ogata E, Ehata S, Miyazono K and Imamura T: Bone morpho-genetic protein signaling enhances invasion and bone metastasis of breast cancer cells through Smad pathway. Oncogene. 27:6322–6333. 2008. View Article : Google Scholar : PubMed/NCBI | |
Gautschi O, Tepper CG, Purnell PR, Izumiya Y, Evans CP, Green TP, Desprez PY, Lara PN, Gandara DR, Mack PC and Kung HJ: Regulation of Id1 expression by SRC: Implications for targeting of the bone morphogenetic protein pathway in cancer. Cancer Res. 68:2250–2258. 2008. View Article : Google Scholar : PubMed/NCBI | |
Buijs JT, Henriquez NV, van Overveld PG, van der Horst G, Que I, Schwaninger R, Rentsch C, Ten Dijke P, Cleton-Jansen AM, Driouch K, et al: Bone morphogenetic protein 7 in the development and treatment of bone metastases from breast cancer. Cancer Res. 67:8742–8751. 2007. View Article : Google Scholar : PubMed/NCBI | |
Du J, Yang S, An D, Hu F, Yuan W, Zhai C and Zhu T: BMP-6 inhibits microRNA-21 expression in breast cancer through repressing deltaEF1 and AP-1. Cell Res. 19:487–496. 2009. View Article : Google Scholar : PubMed/NCBI | |
de Boeck M, Cui C, Mulder AA, Jost CR, Ikeno S and Ten Dijke P: Smad6 determines BMP-regulated invasive behaviour of breast cancer cells in a zebrafish xenograft model. Sci Rep. 6:249682016. View Article : Google Scholar : PubMed/NCBI | |
Luna-Zurita L, Prados B, Grego-Bessa J, Luxán G, del Monte G, Benguría A, Adams RH, Pérez-Pomares JM and de la Pompa JL: Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. J Clin Invest. 120:3493–3507. 2010. View Article : Google Scholar : PubMed/NCBI | |
Ma L, Lu MF, Schwartz RJ and Martin JF: Bmp2 is essential for cardiac cushion epithelial-mesenchymal transition and myocardial patterning. Development. 132:5601–5611. 2005. View Article : Google Scholar : PubMed/NCBI | |
Dyer L, Lockyer P, Wu Y, Saha A, Cyr C, Moser M, Pi X and Patterson C: BMPER promotes epithelial-mesenchymal transition in the developing cardiac cushions. PLoS One. 10:e01392092015. View Article : Google Scholar : PubMed/NCBI | |
Kang MH, Kang HN, Kim JL, Kim JS, Oh SC and Yoo YA: Inhibition of PI3 kinase/Akt pathway is required for BMP2-induced EMT and invasion. Oncol Rep. 22:525–534. 2009.PubMed/NCBI | |
Kang MH, Kim JS, Seo JE, Oh SC and Yoo YA: BMP2 accelerates the motility and invasiveness of gastric cancer cells via activation of the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. Exp Cell Res. 316:24–37. 2010. View Article : Google Scholar | |
Owens P, Polikowsky H, Pickup MW, Gorska AE, Jovanovic B, Shaw AK, Novitskiy SV, Hong CC and Moses HL: Bone Morphogenetic Proteins stimulate mammary fibroblasts to promote mammary carcinoma cell invasion. PLoS One. 8:e675332013. View Article : Google Scholar : PubMed/NCBI | |
Scherberich A, Tucker RP, Degen M, Brown-Luedi M, Andres AC and Chiquet-Ehrismann R: Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro. Oncogene. 24:1525–1532. 2005. View Article : Google Scholar | |
Giussani M, Triulzi T, Sozzi G and Tagliabue E: Tumor extracellular matrix remodeling: New perspectives as a circulating tool in the diagnosis and prognosis of solid tumors. Cells. 8:pii: E81. 2019. View Article : Google Scholar : PubMed/NCBI | |
Eble JA and Niland S: The extracellular matrix in tumor progression and metastasis. Clin Exp Metastasis. 36:171–198. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhong L, Wang X, Wang S, Yang L, Gao H and Yang C: The anti-fibrotic effect of bone morphogenic protein-7(BMP-7) on liver fibrosis. Int J Med Sci. 10:441–450. 2013. View Article : Google Scholar : PubMed/NCBI | |
Li H, Cui D, Zhao F, Huo L, Hu J and Zeng J: BMP-2 is involved in scleral remodeling in myopia development. PLoS One. 10:e01252192015. View Article : Google Scholar : PubMed/NCBI | |
Chen CC and Lau LF: Functions and mechanisms of action of CCN matricellular proteins. Int J Biochem Cell Biol. 41:771–783. 2009. View Article : Google Scholar : | |
Leask A and Abraham DJ: All in the CCN family: Essential matricellular signaling modulators emerge from the bunker. J Cell Sci. 119:4803–4810. 2006. View Article : Google Scholar : PubMed/NCBI | |
Holbourn KP, Acharya KR and Perbal B: The CCN family of proteins: Structure-function relationships. Trends Biochem Sci. 33:461–473. 2008. View Article : Google Scholar : PubMed/NCBI | |
Kireeva ML, Mo FE, Yang GP and Lau LF: Cyr61, a product of a growth factor-inducible immediate-early gene, promotes cell proliferation, migration, and adhesion. Mol Cell Biol. 16:1326–1334. 1996. View Article : Google Scholar : PubMed/NCBI | |
Yosimichi G, Nakanishi T, Nishida T, Hattori T, Takano-Yamamoto T and Takigawa M: CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). Eur J Biochem. 268:6058–6065. 2001. View Article : Google Scholar : PubMed/NCBI | |
Baguma-Nibasheka M and Kablar B: Pulmonary hypoplasia in the connective tissue growth factor (Ctgf) null mouse. Dev Dyn. 237:485–493. 2008. View Article : Google Scholar : PubMed/NCBI | |
Chen CC, Chen N and Lau LF: The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem. 276:10443–10452. 2001. View Article : Google Scholar | |
Liu H, Dong W, Lin Z, Lu J, Wan H, Zhou Z and Liu Z: CCN4 regulates vascular smooth muscle cell migration and proliferation. Mol Cells. 36:112–118. 2013. View Article : Google Scholar : PubMed/NCBI | |
Schutze N, Schenk R, Fiedler J, Mattes T, Jakob F and Brenner RE: CYR61/CCN1 and WISP3/CCN6 are chemoattractive ligands for human multipotent mesenchymal stroma cells. BMC Cell Biol. 8:452007. View Article : Google Scholar : PubMed/NCBI | |
Leu SJ, Lam SC and Lau LF: Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells. J Biol Chem. 277:46248–46255. 2002. View Article : Google Scholar : PubMed/NCBI | |
Todorovic V, Chen CC, Hay N and Lau LF: The matrix protein CCN1 (CYR61) induces apoptosis in fibroblasts. J Cell Biol. 171:559–568. 2005. View Article : Google Scholar : PubMed/NCBI | |
Kubota S and Takigawa M: CCN family proteins and angiogen-esis: from embryo to adulthood. Angiogenesis. 10:1–11. 2007. View Article : Google Scholar | |
Kular L, Pakradouni J, Kitabgi P, Laurent M and Martinerie C: The CCN family: A new class of inflammation modulators? Biochimie. 93:377–388. 2011. View Article : Google Scholar | |
Bai T, Chen CC and Lau LF: Matricellular protein CCN1 activates a proinflammatory genetic program in murine macrophages. J Immunol. 184:3223–3232. 2010. View Article : Google Scholar : PubMed/NCBI | |
Abreu JG, Ketpura NI, Reversade B and De Robertis EM: Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-beta. Nat Cell Biol. 4:599–604. 2002. View Article : Google Scholar : PubMed/NCBI | |
Minamizato T, Sakamoto K, Liu T, Kokubo H, Katsube K, Perbal B, Nakamura S and Yamaguchi A: CCN3/NOV inhibits BMP-2-induced osteoblast differentiation by interacting with BMP and Notch signaling pathways. Biochem Biophys Res Commun. 354:567–573. 2007. View Article : Google Scholar : PubMed/NCBI | |
Ono M, Inkson CA, Kilts TM and Young MF: WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity. J Bone Miner Res. 26:193–208. 2011. View Article : Google Scholar | |
Nakamura Y, Weidinger G, Liang JO, Aquilina-Beck A, Tamai K, Moon RT and Warman ML: The CCN family member Wisp3, mutant in progressive pseudorheumatoid dysplasia, modulates BMP and Wnt signaling. J Clin Invest. 117:3075–3086. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kubota S, Kawaki H, Kondo S, Yosimichi G, Minato M, Nishida T, Hanagata H, Miyauchi A and Takigawa M: Multiple activation of mitogen-activated protein kinases by purified independent CCN2 modules in vascular endothelial cells and chondrocytes in culture. Biochimie. 88:1973–1981. 2006. View Article : Google Scholar : PubMed/NCBI | |
Maeda A, Nishida T, Aoyama E, Kubota S, Lyons KM, Kuboki T and Takigawa M: CCN family 2/connective tissue growth factor modulates BMP signalling as a signal conductor, which action regulates the proliferation and differentiation of chondrocytes. J Biochem. 145:207–216. 2009. View Article : Google Scholar : | |
Maeda S: An impact of CCN2-BMP-2 complex upon chondrocyte biology: Evoking a signalling pathway bypasses ERK and Smads? J Biochem. 150:219–221. 2011. View Article : Google Scholar : PubMed/NCBI | |
Xiao F, Qiu H, Cui H, Ni X, Li J, Liao W, Lu L and Ding K: MicroRNA-885-3p inhibits the growth of HT-29 colon cancer cell xenografts by disrupting angiogenesis via targeting BMPR1A and blocking BMP/Smad/Id1 signaling. Oncogene. 34:1968–1978. 2015. View Article : Google Scholar | |
Nishida N, Nagahara M, Sato T, Mimori K, Sudo T, Tanaka F, Shibata K, Ishii H, Sugihara K, Doki Y and Mori M: Microarray analysis of colorectal cancer stromal tissue reveals upregulation of two oncogenic miRNA clusters. Clin Cancer Res. 18:3054–3070. 2012. View Article : Google Scholar : PubMed/NCBI | |
Okuda S, Myoui A, Nakase T, Wada E, Yonenobu K and Yoshikawa H: Ossification of the ligamentum flavum associated with osteoblastoma: A report of three cases. Skeletal Radiol. 30:402–406. 2001. View Article : Google Scholar : PubMed/NCBI | |
Khurana JS, Ogino S, Shen T, Parekh H, Scherbel U, DeLong W, Feldman MD, Zhang PJ, Wolfe HJ and Alman BA: Bone morphogenetic proteins are expressed by both bone-forming and non-bone-forming lesions. Arch Pathol Lab Med. 128:1267–1269. 2004.PubMed/NCBI | |
Kudo N, Ogose A, Ariizumi T, Kawashima H, Hotta T, Hatano H, Morita T, Nagata M, Siki Y, Kawai A, et al: Expression of bone morphogenetic proteins in giant cell tumor of bone. Anticancer Res. 29:2219–2225. 2009.PubMed/NCBI | |
Urist MR, Grant TT, Lindholm TS, Mirra JM, Hirano H and Finerman GA: Induction of new-bone formation in the host bed by human bone-tumor transplants in athymic nude mice. J Bone Joint Surg Am. 61:1207–1216. 1979. View Article : Google Scholar : PubMed/NCBI | |
Anderson HC, Hsu HH, Raval P, Hunt TR, Schwappach JR, Morris DC and Schneider DJ: The mechanism of bone induction and bone healing by human osteosarcoma cell extracts. Clin Orthop Relat Res. 129–134. 1995.PubMed/NCBI | |
Hara A, Ikeda T, Nomura S, Yagita H, Okumura K and Yamauchi Y: In vivo implantation of human osteosarcoma cells in nude mice induces bones with human-derived osteoblasts and mouse-derived osteocytes. Lab Invest. 75:707–717. 1996.PubMed/NCBI | |
Ishiyama M, Relyea-Chew A, Longstreth WT and Lewis DH: Impact of decompressive craniectomy on brain perfusion scin-tigraphy as an ancillary test for brain death diagnosis. Ann Nucl Med. 33:842–847. 2019. View Article : Google Scholar : PubMed/NCBI | |
Yoshikawa H, Rettig WJ, Takaoka K, Alderman E, Rup B, Rosen V, Wozney JM, Lane JM, Huvos AG and Garin-Chesa P: Expression of bone morphogenetic proteins in human osteo-sarcoma. Immunohistochemical detection with monoclonal antibody. Cancer. 73:85–91. 1994. View Article : Google Scholar : PubMed/NCBI | |
Sulzbacher I, Birner P, Trieb K, Pichlbauer E and Lang S: The expression of bone morphogenetic proteins in osteosarcoma and its relevance as a prognostic parameter. J Clin Pathol. 5:381–385. 2002. View Article : Google Scholar | |
Li B, Yang Y, Jiang S, Ni B, Chen K and Jiang L: Adenovirus-mediated overexpression of BMP-9 inhibits human osteosarcoma cell growth and migration through downregulation of the PI3K/AKT pathway. Int J Oncol. 41:1809–1819. 2012. View Article : Google Scholar : PubMed/NCBI | |
Ye L, Kynaston HG and Jiang WG: Bone metastasis in prostate cancer: Molecular and cellular mechanisms (Review). Int J Mol Med. 20:103–111. 2007.PubMed/NCBI | |
Masuda H, Fukabori Y, Nakano K, Takezawa Y, C Suzuki T and Yamanaka H: Increased expression of bone morphoge-netic protein-7 in bone metastatic prostate cancer. Prostate. 54:268–274. 2003. View Article : Google Scholar : PubMed/NCBI | |
Thomas R, True LD, Lange PH and Vessella RL: Placental bone morphogenetic protein (PLAB) gene expression in normal, pre-malignant and malignant human prostate: Relation to tumor development and progression. Int J Cancer. 93:47–52. 2001. View Article : Google Scholar : PubMed/NCBI | |
Secondini C, Wetterwald A, Schwaninger R, Thalmann GN and Cecchini MG: The role of the BMP signaling antagonist noggin in the development of prostate cancer osteolytic bone metastasis. PLoS One. 6:e160782011. View Article : Google Scholar : PubMed/NCBI | |
Schwaninger R, Rentsch CA, Wetterwald A, van der Horst G, van Bezooijen RL, van der Pluijm G, Löwik CW, Ackermann K, Pyerin W, Hamdy FC, et al: Lack of noggin expression by cancer cells is a determinant of the osteoblast response in bone metastases. Am J Pathol. 170:160–175. 2007. View Article : Google Scholar : PubMed/NCBI | |
Brubaker KD, Corey E, Brown LG and Vessella RL: Bone morphogenetic protein signaling in prostate cancer cell lines. J Cell Biochem. 91:151–160. 2004. View Article : Google Scholar | |
Necchi A, Giannatempo P, Mariani L, Farè E, Raggi D, Pennati M, Zaffaroni N, Crippa F, Marchianò A, Nicolai N, et al: PF-03446962, a fully-human monoclonal antibody against transforming growth-factor β (TGFβ) receptor ALK1, in pre-treated patients with urothelial cancer: An open label, single-group, phase 2 trial. Invest New Drugs. 32:555–560. 2014. View Article : Google Scholar : PubMed/NCBI | |
Mitchell D, Pobre EG, Mulivor AW, Grinberg AV, Castonguay R, Monnell TE, Solban N, Ucran JA, Pearsall RS, Underwood KW, et al: ALK1-Fc inhibits multiple mediators of angiogenesis and suppresses tumor growth. Mol Cancer Ther. 9:379–388. 2010. View Article : Google Scholar : PubMed/NCBI | |
Liu Y, Tian H, Blobe GC, Theuer CP, Hurwitz HI and Nixon AB: Effects of the combination of TRC105 and bevacizumab on endothelial cell biology. Invest New Drugs. 32:851–859. 2014. View Article : Google Scholar : PubMed/NCBI | |
Sun Z, Liu C, Jiang WG and Ye L: Deregulated bone morpho-genetic proteins and their receptors are associated with disease progression of gastric cancer. Comput Struct Biotechnol J. 18:177–188. 2020. View Article : Google Scholar : | |
Hullinger TG, Taichman RS, Linseman DA and Somerman MJ: Secretory products from PC-3 and MCF-7 tumor cell lines upregulate osteopontin in MC3T3-E1 cells. J Cell Biochem. 78:607–616. 2000. View Article : Google Scholar : PubMed/NCBI | |
Yoshioka Y, Ono M, Osaki M, Konishi I and Sakaguchi S: Differential effects of inhibition of bone morphogenic protein (BMP) signalling on T-cell activation and differentiation. Eur J Immunol. 42:749–759. 2012. View Article : Google Scholar | |
Martinez VG, Sacedon R, Hidalgo L, Valencia J, Fernández-Sevilla LM, Hernández-López C, Vicente A and Varas A: The BMP pathway participates in human naive CD4+ T cell activation and homeostasis. PLoS One. 10:e01314532015. View Article : Google Scholar : PubMed/NCBI |