Cooperation between ETS transcription factor ETV1 and histone demethylase JMJD1A in colorectal cancer
- Authors:
- Sangphil Oh
- Hoogeun Song
- Willard M. Freeman
- Sook Shin
- Ralf Janknecht
-
Affiliations: Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA, Stephenson Cancer Center, Oklahoma City, OK 73104, USA - Published online on: October 14, 2020 https://doi.org/10.3892/ijo.2020.5133
- Pages: 1319-1332
-
Copyright: © Oh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Brown TA and McKnight SL: Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins. Genes Dev. 6:2502–2512. 1992. View Article : Google Scholar : PubMed/NCBI | |
Monte D, Coutte L, Baert JL, Angeli I, Stehelin D and de Launoit Y: Molecular characterization of the ets-related human transcription factor ER81. Oncogene. 11:771–779. 1995.PubMed/NCBI | |
Janknecht R: Analysis of the ERK-stimulated ETS transcription factor ER81. Mol Cell Biol. 16:1550–1556. 1996. View Article : Google Scholar : PubMed/NCBI | |
Wei GH, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, et al: Genome-wide analysis of ETS-family DNA-binding in vitro and in vivo. EMBO J. 29:2147–2160. 2010. View Article : Google Scholar : PubMed/NCBI | |
Hollenhorst PC, McIntosh LP and Graves BJ: Genomic and biochemical insights into the specificity of ETS transcription factors. Annu Rev Biochem. 80:437–471. 2011. View Article : Google Scholar : PubMed/NCBI | |
Oh S, Shin S and Janknecht R: ETV1, 4 and 5: An oncogenic subfamily of ETS transcription factors. Biochim Biophys Acta. 1826:1–12. 2012.PubMed/NCBI | |
Arber S, Ladle DR, Lin JH, Frank E and Jessell TM: ETS gene Er81 controls the formation of functional connections between group Ia sensory afferents and motor neurons. Cell. 101:485–498. 2000. View Article : Google Scholar : PubMed/NCBI | |
Kucera J, Cooney W, Que A, Szeder V, Stancz-Szeder H and Walro J: Formation of supernumerary muscle spindles at the expense of Golgi tendon organs in ER81-deficient mice. Dev Dyn. 223:389–401. 2002. View Article : Google Scholar : PubMed/NCBI | |
Sedy J, Tseng S, Walro JM, Grim M and Kucera J: ETS transcription factor ER81 is required for the pacinian corpuscle development. Dev Dyn. 235:1081–1089. 2006. View Article : Google Scholar : PubMed/NCBI | |
Shekhar A, Lin X, Liu FY, Zhang J, Mo H, Bastarache L, Denny JC, Cox NJ, Delmar M, Roden DM, et al: Transcription factor ETV1 is essential for rapid conduction in the heart. J Clin Invest. 126:4444–4459. 2016. View Article : Google Scholar : PubMed/NCBI | |
Papoutsopoulou S and Janknecht R: Phosphorylation of ETS transcription factor ER81 in a complex with its coactivators CREB-binding protein and p300. Mol Cell Biol. 20:7300–7310. 2000.PubMed/NCBI | |
Bosc DG, Goueli BS and Janknecht R: HER2/Neu-mediated activation of the ETS transcription factor ER81 and its target gene MMP-1. Oncogene. 20:6215–6224. 2001.PubMed/NCBI | |
Wu J and Janknecht R: Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A. J Biol Chem. 277:42669–42679. 2002.PubMed/NCBI | |
Xie L, Gazin C, Park SM, Zhu LJ, Debily MA, Kittler EL, Zapp ML, Lapointe D, Gobeil S, Virbasius CM and Green MR: A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. PLoS Genet. 8:e10031512012. | |
Janknecht R: Regulation of the ER81 transcription factor and its coactivators by mitogen- and stress-activated protein kinase 1 (MSK1). Oncogene. 22:746–755. 2003.PubMed/NCBI | |
Goel A and Janknecht R: Acetylation-mediated transcriptional activation of the ETS protein ER81 by p300, P/CAF, and HER2/Neu. Mol Cell Biol. 23:6243–6254. 2003.PubMed/NCBI | |
Baert JL, Monte D, Verreman K, Degerny C, Coutte L and de Launoit Y: The E3 ubiquitin ligase complex component COP1 regulates PEA3 group member stability and transcriptional activity. Oncogene. 29:1810–1820. 2010.PubMed/NCBI | |
Vitari AC, Leong KG, Newton K, Yee C, O'Rourke K, Liu J, Phu L, Vij R, Ferrando R, Couto SS, et al: COP1 is a tumour suppressor that causes degradation of ETS transcription factors. Nature. 474:403–406. 2011.PubMed/NCBI | |
Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, Varambally S, Cao X, Tchinda J, Kuefer R, et al: Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 310:644–648. 2005.PubMed/NCBI | |
Attard G, Clark J, Ambroisine L, Mills IG, Fisher G, Flohr P, Reid A, Edwards S, Kovacs G, Berney D, et al: Heterogeneity and clinical significance of ETV1 translocations in human prostate cancer. Br J Cancer. 99:314–320. 2008.PubMed/NCBI | |
Shin S, Kim TD, Jin F, van Deursen JM, Dehm SM, Tindall DJ, Grande JP, Munz JM, Vasmatzis G and Janknecht R: Induction of prostatic intraepithelial neoplasia and modulation of androgen receptor by ETS variant 1/ETS-related protein 81. Cancer Res. 69:8102–8110. 2009. View Article : Google Scholar : PubMed/NCBI | |
Baena E, Shao Z, Linn DE, Glass K, Hamblen MJ, Fujiwara Y, Kim J, Nguyen M, Zhang X, Godinho FJ, et al: ETV1 directs androgen metabolism and confers aggressive prostate cancer in targeted mice and patients. Genes Dev. 27:683–698. 2013. View Article : Google Scholar : PubMed/NCBI | |
Tomlins SA, Laxman B, Dhanasekaran SM, Helgeson BE, Cao X, Morris DS, Menon A, Jing X, Cao Q, Han B, et al: Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer. Nature. 448:595–599. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kim TD, Jin F, Shin S, Oh S, Lightfoot SA, Grande JP, Johnson AJ, van Deursen JM, Wren JD and Janknecht R: Histone demethylase JMJD2A drives prostate tumorigenesis through transcription factor ETV1. J Clin Invest. 126:706–720. 2016. View Article : Google Scholar : PubMed/NCBI | |
Kooistra SM and Helin K: Molecular mechanisms and potential functions of histone demethylases. Nat Rev Mol Cell Biol. 13:297–311. 2012. View Article : Google Scholar : PubMed/NCBI | |
Berry WL and Janknecht R: KDM4/JMJD2 histone demethylases: Epigenetic regulators in cancer cells. Cancer Res. 73:2936–2942. 2013. View Article : Google Scholar : PubMed/NCBI | |
Oh S, Shin S and Janknecht R: The small members of the JMJD protein family: Enzymatic jewels or jinxes? Biochim Biophys Acta Rev Cancer. 1871:406–418. 2019. View Article : Google Scholar : PubMed/NCBI | |
Whetstine JR, Nottke A, Lan F, Huarte M, Smolikov S, Chen Z, Spooner E, Li E, Zhang G, Colaiacovo M and Shi Y: Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell. 125:467–481. 2006. View Article : Google Scholar : PubMed/NCBI | |
Klose RJ, Yamane K, Bae Y, Zhang D, Erdjument-Bromage H, Tempst P, Wong J and Zhang Y: The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36. Nature. 442:312–316. 2006. View Article : Google Scholar : PubMed/NCBI | |
Shin S and Janknecht R: Diversity within the JMJD2 histone demethylase family. Biochem Biophys Res Commun. 353:973–977. 2007. View Article : Google Scholar : PubMed/NCBI | |
Kim TD, Oh S, Lightfoot SA, Shin S, Wren JD and Janknecht R: Upregulation of PSMD10 caused by the JMJD2A histone demethylase. Int J Clin Exp Med. 9:10123–10134. 2016.PubMed/NCBI | |
Kim TD, Fuchs JR, Schwartz E, Abdelhamid D, Etter J, Berry WL, Li C, Ihnat MA, Li PK and Janknecht R: Pro-growth role of the JMJD2C histone demethylase in HCT-116 colon cancer cells and identification of curcuminoids as JMJD2 inhibitors. Am J Transl Res. 6:236–247. 2014.PubMed/NCBI | |
Kim TD, Shin S, Berry WL, Oh S and Janknecht R: The JMJD2A demethylase regulates apoptosis and proliferation in colon cancer cells. J Cell Biochem. 113:1368–1376. 2012. View Article : Google Scholar | |
Lee HJ, Kim BK, Yoon KB, Kim YC and Han SY: Novel inhibitors of lysine (K)-specific demethylase 4A with anticancer activity. Invest New Drugs. 35:733–741. 2017. View Article : Google Scholar : PubMed/NCBI | |
Crawford HC, Fingleton B, Gustavson MD, Kurpios N, Wagenaar RA, Hassell JA and Matrisian LM: The PEA3 subfamily of Ets transcription factors synergizes with beta-catenin-LEF-1 to activate matrilysin transcription in intestinal tumors. Mol Cell Biol. 21:1370–1383. 2001. View Article : Google Scholar : PubMed/NCBI | |
Horiuchi S, Yamamoto H, Min Y, Adachi Y, Itoh F and Imai K: Association of ets-related transcriptional factor E1AF expression with tumour progression and overexpression of MMP-1 and matrilysin in human colorectal cancer. J Pathol. 200:568–576. 2003. View Article : Google Scholar : PubMed/NCBI | |
Yoo J, Jeon YH, Cho HY, Lee SW, Kim GW, Lee DH and Kwon SH: Advances in histone demethylase KDM3A as a cancer therapeutic target. Cancers (Basel). 12:10982020. View Article : Google Scholar | |
Sui Y, Gu R and Janknecht R: Crucial functions of the JMJD1/KDM3 epigenetic regulators in cancer. Mol Cancer Res. Jun 30–2020.Epub ahead of print. View Article : Google Scholar | |
Uemura M, Yamamoto H, Takemasa I, Mimori K, Hemmi H, Mizushima T, Ikeda M, Sekimoto M, Matsuura N, Doki Y and Mori M: Jumonji domain containing 1A is a novel prognostic marker for colorectal cancer: In vivo identification from hypoxic tumor cells. Clin Cancer Res. 16:4636–4646. 2010. View Article : Google Scholar : PubMed/NCBI | |
Li J, Yu B, Deng P, Cheng Y, Yu Y, Kevork K, Ramadoss S, Ding X, Li X and Wang CY: KDM3 epigenetically controls tumorigenic potentials of human colorectal cancer stem cells through Wnt/β-catenin signalling. Nat Commun. 8:151462017. View Article : Google Scholar | |
Peng K, Su G, Ji J, Yang X, Miao M, Mo P, Li M, Xu J, Li W and Yu C: Histone demethylase JMJD1A promotes colorectal cancer growth and metastasis by enhancing Wnt/β-catenin signaling. J Biol Chem. 293:10606–10619. 2018. View Article : Google Scholar : PubMed/NCBI | |
Li X, Oh S, Song H, Shin S, Zhang B, Freeman WM and Janknecht R: A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer. Oncol Lett. 16:6652–6662. 2018.PubMed/NCBI | |
Dowdy SC, Mariani A and Janknecht R: HER2/Neu- and TAK1-mediated up-regulation of the transforming growth factor beta inhibitor Smad7 via the ETS protein ER81. J Biol Chem. 278:44377–44384. 2003. View Article : Google Scholar : PubMed/NCBI | |
Mooney SM, Goel A, D'Assoro AB, Salisbury JL and Janknecht R: Pleiotropic effects of p300-mediated acetylation on p68 and p72 RNA helicase. J Biol Chem. 285:30443–30452. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kim TD, Shin S and Janknecht R: ETS transcription factor ERG cooperates with histone demethylase KDM4A. Oncol Rep. 35:3679–3688. 2016. View Article : Google Scholar : PubMed/NCBI | |
Oh S, Shin S, Lightfoot SA and Janknecht R: 14-3-3 proteins modulate the ETS transcription factor ETV1 in prostate cancer. Cancer Res. 73:5110–5119. 2013. View Article : Google Scholar : PubMed/NCBI | |
Berry WL, Shin S, Lightfoot SA and Janknecht R: Oncogenic features of the JMJD2A histone demethylase in breast cancer. Int J Oncol. 41:1701–1706. 2012. View Article : Google Scholar : PubMed/NCBI | |
Kim J, Shin S, Subramaniam M, Bruinsma E, Kim TD, Hawse JR, Spelsberg TC and Janknecht R: Histone demethylase JARID1B/KDM5B is a corepressor of TIEG1/KLF10. Biochem Biophys Res Commun. 401:412–416. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kim TD, Oh S, Shin S and Janknecht R: Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D. PLoS One. 7:e346182012. View Article : Google Scholar : PubMed/NCBI | |
Berry WL, Kim TD and Janknecht R: Stimulation of β-catenin and colon cancer cell growth by the KDM4B histone demethylase. Int J Oncol. 44:1341–1348. 2014. View Article : Google Scholar : PubMed/NCBI | |
Rhodes DR, Kalyana-Sundaram S, Mahavisno V, Varambally R, Yu J, Briggs BB, Barrette TR, Anstet MJ, Kincead-Beal C, Kulkarni P, et al: Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles. Neoplasia. 9:166–180. 2007. View Article : Google Scholar : PubMed/NCBI | |
Matthias P, Muller MM, Schreiber E, Rusconi S and Schaffner W: Eukaryotic expression vectors for the analysis of mutant proteins. Nucleic Acids Res. 17:64181989. View Article : Google Scholar : PubMed/NCBI | |
Li X, Moon G, Shin S, Zhang B and Janknecht R: Cooperation between ETS variant 2 and Jumonji domain-containing 2 histone demethylases. Mol Med Rep. 17:5518–5527. 2018.PubMed/NCBI | |
Rossow KL and Janknecht R: The Ewing's sarcoma gene product functions as a transcriptional activator. Cancer Res. 61:2690–2695. 2001.PubMed/NCBI | |
Mooney SM, Grande JP, Salisbury JL and Janknecht R: Sumoylation of p68 and p72 RNA helicases affects protein stability and transactivation potential. Biochemistry. 49:1–10. 2010. View Article : Google Scholar | |
Knebel J, De Haro L and Janknecht R: Repression of transcription by TSGA/Jmjd1a, a novel interaction partner of the ETS protein ER71. J Cell Biochem. 99:319–329. 2006. View Article : Google Scholar : PubMed/NCBI | |
Goel A and Janknecht R: Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu. J Biol Chem. 279:14909–14916. 2004. View Article : Google Scholar : PubMed/NCBI | |
Janknecht R and Hunter T: Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase. J Biol Chem. 272:4219–4224. 1997. View Article : Google Scholar : PubMed/NCBI | |
Yang YL, Wang PW, Wang FS, Lin HY and Huang YH: miR-29a modulates GSK3β/SIRT1-linked mitochondrial proteostatic stress to ameliorate mouse non-alcoholic steatohepatitis. Int J Mol Sci. 21:E68842020. View Article : Google Scholar | |
Lin X, Feng D, Li P and Lv Y: LncRNA LINC00857 regulates the progression and glycolysis in ovarian cancer by modulating the Hippo signaling pathway. Cancer Med. Sep 12–2020.Epub ahead of print. View Article : Google Scholar | |
Chen X, Liu X, Gao Y, Lin J, Liu X, Pang X, Lin J and Chen L: Application of firefly luciferase (Luc) as a reporter gene for the chemoautotrophic and acidophilic Acidithiobacillus spp. Curr Microbiol. 77:3724–3730. 2020. View Article : Google Scholar : PubMed/NCBI | |
Ou Y, Liao C, Li H and Yu G: LncRNA SOX2OT/Smad3 feed-back loop promotes myocardial fibrosis in heart failure. IUBMB Life. Sep 21–2020.Epub ahead of print. View Article : Google Scholar | |
Sims RJ III, Liss AS and Gottlieb PD: Normalization of luciferase reporter assays under conditions that alter internal controls. Biotechniques. 34:938–940. 2003. View Article : Google Scholar : PubMed/NCBI | |
Shifera AS and Hardin JA: Factors modulating expression of Renilla luciferase from control plasmids used in luciferase reporter gene assays. Anal Biochem. 396:167–172. 2010. View Article : Google Scholar | |
Wu GQ, Wang X, Zhou HY, Chai KQ, Xue Q, Zheng AH, Zhu XM, Xiao JY, Ying XH, Wang FW, et al: Evidence for transcriptional interference in a dual-luciferase reporter system. Sci Rep. 5:176752015. View Article : Google Scholar : PubMed/NCBI | |
Repele A and Manu: Robust normalization of luciferase reporter data. Methods Protoc. 2:622019. View Article : Google Scholar : | |
Shin S, Oh S, An S and Janknecht R: ETS variant 1 regulates matrix metalloproteinase-7 transcription in LNCaP prostate cancer cells. Oncol Rep. 29:306–314. 2013. View Article : Google Scholar | |
Shin S, Bosc DG, Ingle JN, Spelsberg TC and Janknecht R: Rcl is a novel ETV1/ER81 target gene upregulated in breast tumors. J Cell Biochem. 105:866–874. 2008. View Article : Google Scholar : PubMed/NCBI | |
Oh S, Shin S, Song H, Grande JP and Janknecht R: Relationship between ETS transcription factor ETV1 and TGF-β-regulated SMAD proteins in prostate cancer. Sci Rep. 9:81862019. View Article : Google Scholar | |
Oh S and Janknecht R: Histone demethylase JMJD5 is essential for embryonic development. Biochem Biophys Res Commun. 420:61–65. 2012. View Article : Google Scholar : PubMed/NCBI | |
Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar | |
Sui Y, Li X, Oh S, Zhang B, Freeman WM, Shin S and Janknecht R: Opposite roles of the JMJD1A interaction partners MDFI and MDFIC in colorectal cancer. Sci Rep. 10:87102020. View Article : Google Scholar : PubMed/NCBI | |
Goueli BS and Janknecht R: Upregulation of the catalytic telomerase subunit by the transcription factor ER81 and oncogenic HER2/Neu, Ras, or Raf. Mol Cell Biol. 24:25–35. 2004. View Article : Google Scholar : | |
Goueli BS and Janknecht R: Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor. Oncogene. 22:8042–8047. 2003. View Article : Google Scholar : PubMed/NCBI | |
DiTacchio L, Bowles J, Shin S, Lim DS, Koopman P and Janknecht R: Transcription factors ER71/ETV2 and SOX9 participate in a positive feedback loop in fetal and adult mouse testis. J Biol Chem. 287:23657–23666. 2012. View Article : Google Scholar : PubMed/NCBI | |
Orlando G, Law PJ, Cornish AJ, Dobbins SE, Chubb D, Broderick P, Litchfield K, Hariri F, Pastinen T, Osborne CS, et al: Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer. Nat Genet. 50:1375–1380. 2018. View Article : Google Scholar : PubMed/NCBI | |
Hong Y, Downey T, Eu KW, Koh PK and Cheah PY: A 'metastasis-prone' signature for early-stage mismatch-repair proficient sporadic colorectal cancer patients and its implications for possible therapeutics. Clin Exp Metastasis. 27:83–90. 2010. View Article : Google Scholar : PubMed/NCBI | |
Skrzypczak M, Goryca K, Rubel T, Paziewska A, Mikula M, Jarosz D, Pachlewski J, Oledzki J and Ostrowski J: Modeling oncogenic signaling in colon tumors by multidirectional analyses of microarray data directed for maximization of analytical reliability. PLoS One. 5:e130912010. View Article : Google Scholar : PubMed/NCBI | |
Smith JJ, Deane NG, Wu F, Merchant NB, Zhang B, Jiang A, Lu P, Johnson JC, Schmidt C, Bailey CE, et al: Experimentally derived metastasis gene expression profile predicts recurrence and death in patients with colon cancer. Gastroenterology. 138:958–968. 2010. View Article : Google Scholar | |
Xie N, Yao Y, Wan L, Zhu T, Liu L and Yuan J: Next-generation sequencing reveals lymph node metastasis associated genetic markers in colorectal cancer. Exp Ther Med. 14:338–343. 2017. View Article : Google Scholar : PubMed/NCBI | |
Cancer Genome Atlas Network: Comprehensive molecular characterization of human colon and rectal cancer. Nature. 487:330–337. 2012. View Article : Google Scholar : PubMed/NCBI | |
Wang Y, Wei J, Zhang S, Li G, Zhang T, Yu X, Chen H and Liu M: Overexpression of Wnt7α protein predicts poor survival in patients with colorectal carcinoma. Tumour Biol. 36:8781–8787. 2015. View Article : Google Scholar : PubMed/NCBI | |
Avgustinova A, Iravani M, Robertson D, Fearns A, Gao Q, Klingbeil P, Hanby AM, Speirs V, Sahai E, Calvo F and Isacke CM: Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness. Nat Commun. 7:103052016. View Article : Google Scholar : PubMed/NCBI | |
Nishioka M, Ueno K, Hazama S, Okada T, Sakai K, Suehiro Y, Okayama N, Hirata H, Oka M, Imai K, et al: Possible involvement of Wnt11 in colorectal cancer progression. Mol Carcinog. 52:207–217. 2013. View Article : Google Scholar | |
He D, Yue Z, Liu L, Fang X, Chen L and Han H: Long noncoding RNA ABHD11-AS1 promote cells proliferation and invasion of colorectal cancer via regulating the miR-1254-WNT11 pathway. J Cell Physiol. 234:12070–12079. 2019. View Article : Google Scholar | |
Kaneda H, Arao T, Tanaka K, Tamura D, Aomatsu K, Kudo K, Sakai K, De Velasco MA, Matsumoto K, Fujita Y, et al: FOXQ1 is overexpressed in colorectal cancer and enhances tumorigenicity and tumor growth. Cancer Res. 70:2053–2063. 2010. View Article : Google Scholar : PubMed/NCBI | |
Abba M, Patil N, Rasheed K, Nelson LD, Mudduluru G, Leupold JH and Allgayer H: Unraveling the role of FOXQ1 in colorectal cancer metastasis. Mol Cancer Res. 11:1017–1028. 2013. View Article : Google Scholar : PubMed/NCBI | |
Peng X, Luo Z, Kang Q, Deng D, Wang Q, Peng H, Wang S and Wei Z: FOXQ1 mediates the crosstalk between TGF-β and Wnt signaling pathways in the progression of colorectal cancer. Cancer Biol Ther. 16:1099–1109. 2015. View Article : Google Scholar : | |
Liu JY, Wu XY, Wu GN, Liu FK and Yao XQ: FOXQ1 promotes cancer metastasis by PI3K/AKT signaling regulation in colorectal carcinoma. Am J Transl Res. 9:2207–2218. 2017.PubMed/NCBI | |
Möller P, Koretz K, Leithäuser F, Brüderlein S, Henne C, Quentmeier A and Krammer PH: Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int J Cancer. 57:371–377. 1994. View Article : Google Scholar : PubMed/NCBI | |
Xiao W, Ibrahim ML, Redd PS, Klement JD, Lu C, Yang D, Savage NM and Liu K: Loss of Fas expression and function Is coupled with colon cancer resistance to immune checkpoint inhibitor immunotherapy. Mol Cancer Res. 17:420–430. 2019. View Article : Google Scholar : | |
Park SJ, Kim HB, Kim J, Park S, Kim SW and Lee JH: The oncogenic effects of p53-inducible gene 3 (PIG3) in colon cancer cells. Korean J Physiol Pharmacol. 21:267–273. 2017. View Article : Google Scholar : PubMed/NCBI | |
Wang SW and Sun YM: The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer. Int J Oncol. 44:1032–1040. 2014. View Article : Google Scholar : PubMed/NCBI | |
Clevers H and Nusse R: Wnt/β-catenin signaling and disease. Cell. 149:1192–1205. 2012. View Article : Google Scholar : PubMed/NCBI | |
Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S and Giaccia AJ: Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 30:344–353. 2010. View Article : Google Scholar | |
Zong Y, Xin L, Goldstein AS, Lawson DA, Teitell MA and Witte ON: ETS family transcription factors collaborate with alternative signaling pathways to induce carcinoma from adult murine prostate cells. Proc Natl Acad Sci USA. 106:12465–12470. 2009. View Article : Google Scholar : PubMed/NCBI | |
Fan L, Peng G, Sahgal N, Fazli L, Gleave M, Zhang Y, Hussain A and Qi J: Regulation of c-Myc expression by the histone demethylase JMJD1A is essential for prostate cancer cell growth and survival. Oncogene. 35:2441–2452. 2016. View Article : Google Scholar : | |
Wilson S, Fan L, Sahgal N, Qi J and Filipp FV: The histone demethylase KDM3A regulates the transcriptional program of the androgen receptor in prostate cancer cells. Oncotarget. 8:30328–30343. 2017. View Article : Google Scholar : PubMed/NCBI | |
Fan L, Zhang F, Xu S, Cui X, Hussain A, Fazli L, Gleave M, Dong X and Qi J: Histone demethylase JMJD1A promotes alter-native splicing of AR variant 7 (AR-V7) in prostate cancer cells. Proc Natl Acad Sci USA. 115:E4584–E4593. 2018. View Article : Google Scholar | |
Tang DE, Dai Y, Fan LL, Geng XY, Fu DX, Jiang HW and Xu SH: Histone demethylase JMJD1A promotes tumor progression via activating Snail in prostate cancer. Mol Cancer Res. 18:698–708. 2020. View Article : Google Scholar : PubMed/NCBI | |
Ikeda H, Old LJ and Schreiber RD: The roles of IFN gamma in protection against tumor development and cancer immunoediting. Cytokine Growth Factor Rev. 13:95–109. 2002. View Article : Google Scholar : PubMed/NCBI | |
Mojic M, Takeda K and Hayakawa Y: The dark side of IFN-ү: Its role in promoting cancer immunoevasion. Int J Mol Sci. 19:892017. View Article : Google Scholar | |
Jung B, Staudacher JJ and Beauchamp D: Transforming growth factor β superfamily signaling in development of colorectal cancer. Gastroenterology. 152:36–52. 2017. View Article : Google Scholar | |
Jiao HL, Ye YP, Yang RW, Sun HY, Wang SY, Wang YX, Xiao ZY, He LQ, Cai JJ, Wei WT, et al: Downregulation of SAFB sustains the NF-κB pathway by targeting TAK1 during the progression of colorectal cancer. Clin Cancer Res. 23:7108–7118. 2017. View Article : Google Scholar : PubMed/NCBI | |
Weng W, Okugawa Y, Toden S, Toiyama Y, Kusunoki M and Goel A: FOXM1 and FOXQ1 are promising prognostic biomarkers and novel targets of tumor-suppressive miR-342 in human colorectal cancer. Clin Cancer Res. 22:4947–4957. 2016. View Article : Google Scholar : PubMed/NCBI | |
Bagati A, Bianchi-Smiraglia A, Moparthy S, Kolesnikova K, Fink EE, Lipchick BC, Kolesnikova M, Jowdy P, Polechetti A, Mahpour A, et al: Melanoma suppressor functions of the carcinoma oncogene FOXQ1. Cell Rep. 20:2820–2832. 2017. View Article : Google Scholar : PubMed/NCBI | |
Nau MM, Brooks BJ, Battey J, Sausville E, Gazdar AF, Kirsch IR, McBride OW, Bertness V, Hollis GF and Minna JD: L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature. 318:69–73. 1985. View Article : Google Scholar : PubMed/NCBI | |
Wu R, Lin L, Beer DG, Ellenson LH, Lamb BJ, Rouillard JM, Kuick R, Hanash S, Schwartz DR, Fearon ER and Cho KR: Amplification and overexpression of the L-MYC proto-onco-gene in ovarian carcinomas. Am J Pathol. 162:1603–1610. 2003. View Article : Google Scholar : PubMed/NCBI | |
Boutros PC, Fraser M, Harding NJ, de Borja R, Trudel D, Lalonde E, Meng A, Hennings-Yeomans PH, McPherson A, Sabelnykova VY, et al: Spatial genomic heterogeneity within localized, multifocal prostate cancer. Nat Genet. 47:736–745. 2015. View Article : Google Scholar : PubMed/NCBI | |
Huijbers IJ, Bin Ali R, Pritchard C, Cozijnsen M, Kwon MC, Proost N, Song JY, de Vries H, Badhai J, Sutherland K, et al: Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol Med. 6:212–225. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kim DW, Wu N, Kim YC, Cheng PF, Basom R, Kim D, Dunn CT, Lee AY, Kim K, Lee CS, et al: Genetic requirement for Mycl and efficacy of RNA Pol I inhibition in mouse models of small cell lung cancer. Genes Dev. 30:1289–1299. 2016. View Article : Google Scholar : PubMed/NCBI | |
Möröy T, Fisher P, Guidos C, Ma A, Zimmerman K, Tesfaye A, DePinho R, Weissman I and Alt FW: IgH enhancer deregulated expression of L-myc: Abnormal T lymphocyte development and T cell lymphomagenesis. EMBO J. 9:3659–3666. 1990. View Article : Google Scholar : PubMed/NCBI | |
Chapman DL and Papaioannou VE: Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 391:695–697. 1998. View Article : Google Scholar : PubMed/NCBI | |
Sandbacka M, Laivuori H, Freitas E, Halttunen M, Jokimaa V, Morin-Papunen L, Rosenberg C and Aittomaki K: TBX6, LHX1 and copy number variations in the complex genetics of Mullerian aplasia. Orphanet J Rare Dis. 8:1252013. View Article : Google Scholar | |
Wu N, Ming X, Xiao J, Wu Z, Chen X, Shinawi M, Shen Y, Yu G, Liu J, Xie H, et al: TBX6 null variants and a common hypomorphic allele in congenital scoliosis. N Engl J Med. 372:341–350. 2015. View Article : Google Scholar : PubMed/NCBI | |
Verbitsky M, Westland R, Perez A, Kiryluk K, Liu Q, Krithivasan P, Mitrotti A, Fasel DA, Batourina E, Sampson MG, et al: The copy number variation landscape of congenital anomalies of the kidney and urinary tract. Nat Genet. 51:117–127. 2019. View Article : Google Scholar : | |
Ren X, Yang N, Wu N, Xu X, Chen W, Zhang L, Li Y, Du RQ, Dong S, Zhao S, et al: Increased TBX6 gene dosages induce congenital cervical vertebral malformations in humans and mice. J Med Genet. 57:371–379. 2020. View Article : Google Scholar : PubMed/NCBI | |
Takemoto T, Uchikawa M, Yoshida M, Bell DM, Lovell-Badge R, Papaioannou VE and Kondoh H: Tbx6-dependent Sox2 regulation determines neural or mesodermal fate in axial stem cells. Nature. 470:394–398. 2011. View Article : Google Scholar : PubMed/NCBI | |
Sadahiro T, Isomi M, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tamura F, Tani H, Tohyama S, Fujita J, et al: Tbx6 induces nascent mesoderm from pluripotent stem cells and temporally controls cardiac versus somite lineage diversification. Cell Stem Cell. 23:382–395.e5. 2018. View Article : Google Scholar : PubMed/NCBI | |
Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Ioue Y, Miki C and Kusunoki M: Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy. Ann Surg Oncol. 16:3488–3498. 2009. View Article : Google Scholar : PubMed/NCBI | |
Ong CW, Kim LG, Kong HH, Low LY, Iacopetta B, Soong R and Salto-Tellez M: CD133 expression predicts for non-response to chemotherapy in colorectal cancer. Mod Pathol. 23:450–457. 2010. View Article : Google Scholar : PubMed/NCBI | |
Neumann J, Bahr F, Horst D, Kriegl L, Engel J, Luque RM, Gerhard M, Kirchner T and Jung A: SOX2 expression correlates with lymph-node metastases and distant spread in right-sided colon cancer. BMC Cancer. 11:5182011. View Article : Google Scholar : PubMed/NCBI |