Open Access

Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review)

  • Authors:
    • Mark A. Baxter
    • Russell D. Petty
    • Daniel Swinson
    • Peter S. Hall
    • Shane O'Hanlon
  • View Affiliations

  • Published online on: March 17, 2021     https://doi.org/10.3892/ijo.2021.5202
  • Article Number: 22
  • Copyright: © Baxter et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Gastroesophageal adenocarcinoma (GOA) is a disease of older people. Incidence is rising in the developed world and the majority of patients present with advanced disease. Based on clinical trial data, systemic chemotherapy in the advanced setting is associated with improvements in quality of life and survival. However, there is a recognised mismatch between trial populations and the patients encountered in clinical practice in terms of age, comorbidity and fitness. Appropriate patient selection is essential to safely deliver effective treatment. In this narrative review, we discuss the challenges faced by clinicians when assessing real‑world patients with advanced GOA for systemic therapy. We also highlight the importance of frailty screening and the current available evidence we can use to guide our management.
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May-2021
Volume 58 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Baxter MA, Petty RD, Swinson D, Hall PS and O'Hanlon S: Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review). Int J Oncol 58: 22, 2021.
APA
Baxter, M.A., Petty, R.D., Swinson, D., Hall, P.S., & O'Hanlon, S. (2021). Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review). International Journal of Oncology, 58, 22. https://doi.org/10.3892/ijo.2021.5202
MLA
Baxter, M. A., Petty, R. D., Swinson, D., Hall, P. S., O'Hanlon, S."Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review)". International Journal of Oncology 58.5 (2021): 22.
Chicago
Baxter, M. A., Petty, R. D., Swinson, D., Hall, P. S., O'Hanlon, S."Real‑world challenge for clinicians treating advanced gastroesophageal adenocarcinoma (Review)". International Journal of Oncology 58, no. 5 (2021): 22. https://doi.org/10.3892/ijo.2021.5202