lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review

  • Authors:
    • Unai Illarregi
    • Jaione Telleria
    • Nerea Bilbao‑Aldaiturriaga
    • Elixabet Lopez‑Lopez
    • Javier Ballesteros
    • Idoia Martin‑Guerrero
    • Angela Gutierrez‑Camino
  • View Affiliations

  • Published online on: April 7, 2022     https://doi.org/10.3892/ijo.2022.5348
  • Article Number: 59
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Abstract

Childhood acute lymphoblastic leukemia (ALL), the most common pediatric cancer, is a heterogeneous disease comprised of multiple molecular subtypes with distinct somatic genetic alterations, which results in different outcomes for the patients. Accurate patient risk stratification through genetic markers could increase survival rates, but the identification of reliable biomarkers is needed, as 20‑30% of B‑ALL patients cannot be classified in the clinic with routine techniques and some patients classified as low‑risk and good‑responders to treatment will eventually relapse. Long non‑coding RNAs (lncRNAs) can represent novel candidates with diagnostic, classification, prognosis, and treatment response potential. However, regarding childhood ALL, there is inconsistency in the data reported due to the lack of a consensus nomenclature for lncRNA naming and the methodology and designing applied for their study. Therefore, the aim of the article is to clarify the potential of lncRNAs as biomarkers in childhood ALL through a systematic review. From a revision of 23 manuscripts, it was found that AWPPH overexpression could represent a novel marker for ALL diagnosis, including both B and T immunophenotypes, and 18 lncRNAs were specifically associated with B‑cell ALL (B‑ALL) patients. We identified subtype‑specific signatures for ETV6‑RUNX1, hyperdiploidy and KMT2A subtypes. These signatures hold promise as novel diagnostic markers and could refine the classification of patients.
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May-2022
Volume 60 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Illarregi U, Telleria J, Bilbao‑Aldaiturriaga N, Lopez‑Lopez E, Ballesteros J, Martin‑Guerrero I and Gutierrez‑Camino A: lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review. Int J Oncol 60: 59, 2022.
APA
Illarregi, U., Telleria, J., Bilbao‑Aldaiturriaga, N., Lopez‑Lopez, E., Ballesteros, J., Martin‑Guerrero, I., & Gutierrez‑Camino, A. (2022). lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review. International Journal of Oncology, 60, 59. https://doi.org/10.3892/ijo.2022.5348
MLA
Illarregi, U., Telleria, J., Bilbao‑Aldaiturriaga, N., Lopez‑Lopez, E., Ballesteros, J., Martin‑Guerrero, I., Gutierrez‑Camino, A."lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review". International Journal of Oncology 60.5 (2022): 59.
Chicago
Illarregi, U., Telleria, J., Bilbao‑Aldaiturriaga, N., Lopez‑Lopez, E., Ballesteros, J., Martin‑Guerrero, I., Gutierrez‑Camino, A."lncRNA deregulation in childhood acute lymphoblastic leukemia: A systematic review". International Journal of Oncology 60, no. 5 (2022): 59. https://doi.org/10.3892/ijo.2022.5348