Open Access

Targeting neddylation as a novel approach to lung cancer treatment (Review)

  • Authors:
    • Zhaochun Tian
    • Jiafei Li
    • Ruijie Ma
    • Ting Li
    • Zhigang Sun
    • Shuhong Huang
  • View Affiliations

  • Published online on: April 20, 2023     https://doi.org/10.3892/ijo.2023.5513
  • Article Number: 65
  • Copyright: © Tian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

As a protein that resembles ubiquitin, neural precursor cell expressed developmentally downregulated 8 (NEDD8) takes part in neddylation, which modifies substrates in a manner similar to ubiquitination and alters the activity of target proteins. Neddylation may affect the activity of multiple signaling pathways, have a regulatory role in tumor formation, progression and metastasis, and influence the prognosis of cancer treatment. The present review summarizes the regulatory roles of NEDD8 in the MDM2‑p53, NF‑κB, PI3K/AKT/mTOR, hypoxia‑inducible factor, Hippo and receptor tyrosine kinase signaling pathways, as well as in the development and progression of lung cancer.
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May-2023
Volume 62 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Tian Z, Li J, Ma R, Li T, Sun Z and Huang S: Targeting neddylation as a novel approach to lung cancer treatment (Review). Int J Oncol 62: 65, 2023.
APA
Tian, Z., Li, J., Ma, R., Li, T., Sun, Z., & Huang, S. (2023). Targeting neddylation as a novel approach to lung cancer treatment (Review). International Journal of Oncology, 62, 65. https://doi.org/10.3892/ijo.2023.5513
MLA
Tian, Z., Li, J., Ma, R., Li, T., Sun, Z., Huang, S."Targeting neddylation as a novel approach to lung cancer treatment (Review)". International Journal of Oncology 62.5 (2023): 65.
Chicago
Tian, Z., Li, J., Ma, R., Li, T., Sun, Z., Huang, S."Targeting neddylation as a novel approach to lung cancer treatment (Review)". International Journal of Oncology 62, no. 5 (2023): 65. https://doi.org/10.3892/ijo.2023.5513