Open Access

Endocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review)

  • Authors:
    • Monica Cantile
    • Margherita Cerrone
    • Maurizio Di Bonito
    • Pasquale Moccia
    • Maura Tracey
    • Gerardo Ferrara
    • Alfredo Budillon
  • View Affiliations

  • Published online on: November 29, 2023     https://doi.org/10.3892/ijo.2023.5595
  • Article Number: 7
  • Copyright: © Cantile et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Nuclear receptors (NRs) are transcriptional regulators involved in different aspects of normal cell physiology. Their deregulation is associated with aberrant expression, gene mutations and/or epigenetic alterations that can be related to the pathogenesis of various human diseases, and especially in cancer. In particular, a complex genomic network involved in the development and progression of NR‑mediated cancer has been highlighted. Advanced genomic technologies have made it possible to understand that the expression of any particular NR in a given cancer subtype is only one component of a larger transcriptional machinery that is controlled by multiple associated NRs and transcription factors. Additionally, their ability to regulate and to be regulated by molecules of non‑coding RNAs, microRNAs as well as long non‑coding RNAs, is opening new scenarios for understanding the role of NRs in cancer initiation and progression. In the present review, the authors aimed to outline the reciprocal interactions that exist between the main NRs and long non‑coding RNAs in different tumor diseases, to suggest new diagnostic biomarkers as well as therapeutic strategies for these tumors.
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January-2024
Volume 64 Issue 1

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Online ISSN:1791-2423

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Spandidos Publications style
Cantile M, Cerrone M, Di Bonito M, Moccia P, Tracey M, Ferrara G and Budillon A: Endocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review). Int J Oncol 64: 7, 2024.
APA
Cantile, M., Cerrone, M., Di Bonito, M., Moccia, P., Tracey, M., Ferrara, G., & Budillon, A. (2024). Endocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review). International Journal of Oncology, 64, 7. https://doi.org/10.3892/ijo.2023.5595
MLA
Cantile, M., Cerrone, M., Di Bonito, M., Moccia, P., Tracey, M., Ferrara, G., Budillon, A."Endocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review)". International Journal of Oncology 64.1 (2024): 7.
Chicago
Cantile, M., Cerrone, M., Di Bonito, M., Moccia, P., Tracey, M., Ferrara, G., Budillon, A."Endocrine nuclear receptors and long non‑coding RNAs reciprocal regulation in cancer (Review)". International Journal of Oncology 64, no. 1 (2024): 7. https://doi.org/10.3892/ijo.2023.5595