Biological functions of circRNA in regulating the hallmarks of gastrointestinal cancer (Review)
- Authors:
- Mengjun Qiu
- Youxiang Chen
- Chunyan Zeng
-
Affiliations: Department of Gastroenterology, Digestive Disease Hospital, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330006, P.R. China - Published online on: March 15, 2024 https://doi.org/10.3892/ijo.2024.5637
- Article Number: 49
-
Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
Venø MT, Hansen TB, Venø ST, Clausen BH, Grebing M, Finsen B, Holm IE and Kjems J: Spatio-temporal regulation of circular RNA expression during porcine embryonic brain development. Genome Biol. 16:2452015. View Article : Google Scholar : PubMed/NCBI | |
Rybak-Wolf A, Stottmeister C, Glažar P, Jens M, Pino N, Giusti S, Hanan M, Behm M, Bartok O, Ashwal-Fluss R, et al: Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell. 58:870–885. 2015. View Article : Google Scholar : PubMed/NCBI | |
Guo JU, Agarwal V, Guo H and Bartel DP: Expanded identification and characterization of mammalian circular RNAs. Genome Biol. 15:4092014. View Article : Google Scholar : PubMed/NCBI | |
Li Z, Huang C, Bao C, Chen L, Lin M, Wang X, Zhong G, Yu B, Hu W, Dai L, et al: Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 22:256–264. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Zhang XO, Chen T, Xiang JF, Yin QF, Xing YH, Zhu S, Yang L and Chen LL: Circular intronic long noncoding RNAs. Mol Cell. 51:792–806. 2013. View Article : Google Scholar : PubMed/NCBI | |
Lasda E and Parker R: Circular RNAs: Diversity of form and function. RNA. 20:1829–1842. 2014. View Article : Google Scholar : PubMed/NCBI | |
Piwecka M, Glažar P, Hernandez-Miranda LR, Memczak S, Wolf SA, Rybak-Wolf A, Filipchyk A, Klironomos F, Cerda Jara CA, Fenske P, et al: Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science. 357:eaam85262017. View Article : Google Scholar : PubMed/NCBI | |
Memczak S, Jens M, Elefsinioti A, Torti F, Krueger J, Rybak A, Maier L, Mackowiak SD, Gregersen LH, Munschauer M, et al: Circular RNAs are a large class of animal RNAs with regulatory potency. Nature. 495:333–338. 2013. View Article : Google Scholar : PubMed/NCBI | |
Hansen TB, Jensen TI, Clausen BH, Bramsen JB, Finsen B, Damgaard CK and Kjems J: Natural RNA circles function as efficient microRNA sponges. Nature. 495:384–388. 2013. View Article : Google Scholar : PubMed/NCBI | |
Conn SJ, Pillman KA, Toubia J, Conn VM, Salmanidis M, Phillips CA, Roslan S, Schreiber AW, Gregory PA and Goodall GJ: The RNA binding protein quaking regulates formation of circRNAs. Cell. 160:1125–1134. 2015. View Article : Google Scholar : PubMed/NCBI | |
Zang J, Lu D and Xu A: The interaction of circRNAs and RNA binding proteins: An important part of circRNA maintenance and function. J Neurosci Res. 98:87–97. 2020. View Article : Google Scholar | |
Legnini I, Di Timoteo G, Rossi F, Morlando M, Briganti F, Sthandier O, Fatica A, Santini T, Andronache A, Wade M, et al: Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell. 66:22–37.e9. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yang F, Hu A, Li D, Wang J, Guo Y, Liu Y, Li H, Chen Y, Wang X, Huang K, et al: Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation. Mol Cancer. 18:1582019. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Gao X, Zhang M, Yan S, Sun C, Xiao F, Huang N, Yang X, Zhao K, Zhou H, et al: Novel Role of FBXW7 Circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst. 110:304–315. 2018. View Article : Google Scholar : | |
Chen CY and Sarnow P: Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs. Science. 268:415–417. 1995. View Article : Google Scholar : PubMed/NCBI | |
Pamudurti NR, Bartok O, Jens M, Ashwal-Fluss R, Stottmeister C, Ruhe L, Hanan M, Wyler E, Perez-Hernandez D, Ramberger E, et al: Translation of CircRNAs. Mol Cell. 66:9–21.e7. 2017. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Fan X, Mao M, Song X, Wu P, Zhang Y, Jin Y, Yang Y, Chen LL, Wang Y, et al: Extensive translation of circular RNAs driven by N6-methyladenosine. Cell Res. 27:626–641. 2017. View Article : Google Scholar : PubMed/NCBI | |
Ashwal-Fluss R, Meyer M, Pamudurti NR, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N and Kadener S: circRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 56:55–66. 2014. View Article : Google Scholar : PubMed/NCBI | |
Chao CW, Chan DC, Kuo A and Leder P: The mouse formin (Fmn) gene: Abundant circular RNA transcripts and gene-targeted deletion analysis. Mol Med. 4:614–628. 1998. View Article : Google Scholar : PubMed/NCBI | |
Gualandi F, Trabanelli C, Rimessi P, Calzolari E, Toffolatti L, Patarnello T, Kunz G, Muntoni F and Ferlini A: Multiple exon skipping and RNA circularisation contribute to the severe phenotypic expression of exon 5 dystrophin deletion. J Med Genet. 40:e1002003. View Article : Google Scholar : PubMed/NCBI | |
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
Thrift AP and El-Serag HB: Burden of gastric cancer. Clin Gastroenterol Hepatol. 18:534–542. 2020. View Article : Google Scholar | |
Martínez-Bosch N, Cristóbal H, Iglesias M, Gironella M, Barranco L, Visa L, Calafato D, Jiménez-Parrado S, Earl J, Carrato A, et al: Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis. EBioMedicine. 75:1037972022. View Article : Google Scholar : PubMed/NCBI | |
Abe T, Blackford AL, Tamura K, Ford M, McCormick P, Chuidian M, Almario JA, Borges M, Lennon AM, Shin EJ, et al: Deleterious germline mutations are a risk factor for neoplastic progression among high-risk individuals undergoing pancreatic surveillance. J Clin Oncol. 37:1070–1080. 2019. View Article : Google Scholar : PubMed/NCBI | |
Vincent A, Herman J, Schulick R, Hruban RH and Goggins M: Pancreatic cancer. Lancet. 378:607–620. 2011. View Article : Google Scholar : PubMed/NCBI | |
Thanikachalam K and Khan G: Colorectal cancer and nutrition. Nutrients. 11:1642019. View Article : Google Scholar : PubMed/NCBI | |
Li R, Jiang J, Shi H, Qian H, Zhang X and Xu W: CircRNA: A rising star in gastric cancer. Cell Mol Life Sci. 77:1661–1680. 2020. View Article : Google Scholar | |
Li J, Xu Q, Huang ZJ, Mao N, Lin ZT, Cheng L, Sun B and Wang G: CircRNAs: A new target for the diagnosis and treatment of digestive system neoplasms. Cell Death Dis. 12:2052021. View Article : Google Scholar : PubMed/NCBI | |
Dragomir MP, Kopetz S, Ajani JA and Calin GA: Non-coding RNAs in GI cancers: From cancer hallmarks to clinical utility. Gut. 69:748–763. 2020. View Article : Google Scholar : PubMed/NCBI | |
Salzman J, Chen RE, Olsen MN, Wang PL and Brown PO: Cell-type specific features of circular RNA expression. PLoS Genet. 9:e10037772013. View Article : Google Scholar : PubMed/NCBI | |
Jeck WR, Sorrentino JA, Wang K, Slevin MK, Burd CE, Liu J, Marzluff WF and Sharpless NE: Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 19:141–157. 2013. View Article : Google Scholar : | |
Zhang XO, Wang HB, Zhang Y, Lu X, Chen LL and Yang L: Complementary sequence-mediated exon circularization. Cell. 159:134–147. 2014. View Article : Google Scholar : PubMed/NCBI | |
Zhang PF, Gao C, Huang XY, Lu JC, Guo XJ, Shi GM, Cai JB and Ke AW: Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma. Mol Cancer. 19:1102020. View Article : Google Scholar : PubMed/NCBI | |
Zhou C, Liu HS, Wang FW, Hu T, Liang ZX, Lan N, He XW, Zheng XB, Wu XJ, Xie D, et al: circCAMSAP1 promotes tumor growth in colorectal cancer via the miR-328-5p/E2F1 axis. Mol Ther. 28:914–928. 2020. View Article : Google Scholar : PubMed/NCBI | |
Zhang X, Wang S, Wang H, Cao J, Huang X, Chen Z, Xu P, Sun G, Xu J, Lv J and Xu Z: Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Mol Cancer. 18:202019. View Article : Google Scholar : PubMed/NCBI | |
Kristensen LS, Okholm T, Venø MT and Kjems J: Circular RNAs are abundantly expressed and upregulated during human epidermal stem cell differentiation. RNA Biol. 15:280–291. 2018. View Article : Google Scholar : | |
Yang F, Fang E, Mei H, Chen Y, Li H, Li D, Song H, Wang J, Hong M, Xiao W, et al: Cis-Acting circ-CTNNB1 promotes β-catenin signaling and cancer progression via DDX3-mediated transactivation of YY1. Cancer Res. 79:557–571. 2019. View Article : Google Scholar | |
Du WW, Yang W, Liu E, Yang Z, Dhaliwal P and Yang BB: Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2. Nucleic Acids Res. 44:2846–2858. 2016. View Article : Google Scholar : PubMed/NCBI | |
Marques R, Lacerda R and Romão L: Internal ribosome entry site (IRES)-mediated translation and its potential for novel mRNA-based therapy development. Biomedicines. 10:18652022. View Article : Google Scholar : PubMed/NCBI | |
Fan X, Yang Y, Chen C and Wang Z: Pervasive translation of circular RNAs driven by short IRES-like elements. Nat Commun. 13:37512022. View Article : Google Scholar : PubMed/NCBI | |
Chen LL: The expanding regulatory mechanisms and cellular functions of circular RNAs. Nat Rev Mol Cell Biol. 21:475–490. 2020. View Article : Google Scholar : PubMed/NCBI | |
Zheng X, Chen L, Zhou Y, Wang Q, Zheng Z, Xu B, Wu C, Zhou Q, Hu W, Wu C and Jiang J: A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling. Mol Cancer. 18:472019. View Article : Google Scholar : PubMed/NCBI | |
Kelly S, Greenman C, Cook PR and Papantonis A: Exon skipping is correlated with exon circularization. J Mol Biol. 427:2414–2417. 2015. View Article : Google Scholar : PubMed/NCBI | |
Hu X, Wu D, He X, Zhao H, He Z, Lin J, Wang K, Wang W, Pan Z, Lin H and Wang M: circGSK3β promotes metastasis in esophageal squamous cell carcinoma by augmenting β-catenin signaling. Mol Cancer. 18:1602019. View Article : Google Scholar | |
Shi Y, Fang N, Li Y, Guo Z, Jiang W, He Y, Ma Z and Chen Y: Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis. Cancer Sci. 111:2824–2836. 2020. View Article : Google Scholar : PubMed/NCBI | |
Liu ZH, Yang SZ, Li WY, Dong SY, Zhou SY and Xu S: circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene. Aging (Albany NY). 13:12179–12193. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhong R, Chen Z, Mo T, Li Z and Zhang P: Potential role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma. Cancer Cell Int. 19:2672019. View Article : Google Scholar : PubMed/NCBI | |
Li RC, Ke S, Meng FK, Lu J, Zou XJ, He ZG, Wang WF and Fang MH: CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13. Cell Death Dis. 9:8382018. View Article : Google Scholar : PubMed/NCBI | |
Shi Y, Guo Z, Fang N, Jiang W, Fan Y, He Y, Ma Z and Chen Y: hsa_circ_0006168 sponges miR-100 and regulates mTOR to promote the proliferation, migration and invasion of esophageal squamous cell carcinoma. Biomed Pharmacother. 117:1091512019. View Article : Google Scholar : PubMed/NCBI | |
Qu F, Wang L, Wang C, Yu L, Zhao K and Zhong H: Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis. Cancer Cell Int. 21:2732021. View Article : Google Scholar : PubMed/NCBI | |
Zhou S, Guo Z, Zhou C, Zhang Y and Wang S: circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway. Cancer Cell Int. 21:2502021. View Article : Google Scholar : PubMed/NCBI | |
Gu L, Sang Y, Nan X, Zheng Y, Liu F, Meng L, Sang M and Shan B: circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF-kappaB-induced CCL5 secretion. Mol Cancer. 21:2172022. View Article : Google Scholar | |
Wang C, Zhou M, Zhu P, Ju C, Sheng J, Du D, Wan J, Yin H, Xing Y, Li H, et al: IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis. J Exp Clin Cancer Res. 41:3472022. View Article : Google Scholar : PubMed/NCBI | |
Meng F, Zhang X, Wang Y, Lin J, Tang Y, Zhang G, Qiu B, Zeng X, Liu W and He X: Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFκB pathway. Cell Death Dis. 14:92023. View Article : Google Scholar | |
Yao W, Jia X, Zhu L, Xu L, Zhang Q, Xia T and Wei L: Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs). Cell Mol Biol Lett. 28:132023. View Article : Google Scholar : PubMed/NCBI | |
Luo J, Tian Z, Zhou Y, Xiao Z, Park SY, Sun H, Zhuang T, Wang Y, Li P and Zhao X: CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1. Cancer Sci. 114:2835–2847. 2023. View Article : Google Scholar : PubMed/NCBI | |
Wang Z, Ma K, Cheng Y, Abraham JM, Liu X, Ke X, Wang Z and Meltzer SJ: Synthetic circular multi-miR sponge simultaneously inhibits miR-21 and miR-93 in esophageal carcinoma. Lab Invest. 99:1442–1453. 2019. View Article : Google Scholar : PubMed/NCBI | |
Wang H, Song X, Wang Y, Yin X, Liang Y, Zhang T, Xu L, Jiang F and Dong G: CircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma. Cell Death Dis. 11:10102020. View Article : Google Scholar : PubMed/NCBI | |
He Y, Mingyan E, Wang C, Liu G, Shi M and Liu S: CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway. Int J Biol Macromol. 125:116–123. 2019. View Article : Google Scholar | |
Meng L, Zheng Y, Liu S, Ju Y, Ren S, Sang Y, Zhu Y, Gu L, Liu F, Zhao Y, et al: ZEB1 represses biogenesis of circ-DOCK5 to facilitate metastasis in esophageal squamous cell carcinoma via a positive feedback loop with TGF-β. Cancer Lett. 519:117–129. 2021. View Article : Google Scholar : PubMed/NCBI | |
Zhao R, Chen P, Qu C, Liang J, Cheng Y, Sun Z and Tian H: Circular RNA circTRPS1-2 inhibits the proliferation and migration of esophageal squamous cell carcinoma by reducing the production of ribosomes. Cell Death Discov. 9:52023. View Article : Google Scholar : PubMed/NCBI | |
Xu R, Ding P, Zhao X, Li Z, Liu F, Gu L, Zheng Y, Sang M and Meng L: Circular RNA circ-TNRC6B inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by regulating the miR-452-5p/DAG1 axis. Mol Oncol. 17:1437–1452. 2023. View Article : Google Scholar : PubMed/NCBI | |
Song H, Tian D, Sun J, Mao X, Kong W, Xu D, Ji Y, Qiu B, Zhan M and Wang J: circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway. Cell Death Dis. 13:3612022. View Article : Google Scholar : PubMed/NCBI | |
Xie M, Yu T, Jing X, Ma L, Fan Y, Yang F, Ma P, Jiang H, Wu X, Shu Y and Xu T: Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation. Mol Cancer. 19:1122020. View Article : Google Scholar : PubMed/NCBI | |
Huang X, Li Z, Zhang Q, Wang W, Li B, Wang L, Xu Z, Zeng A, Zhang X, Zhang X, et al: Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression. Mol Cancer. 18:712019. View Article : Google Scholar : PubMed/NCBI | |
Cao J, Zhang X, Xu P, Wang H, Wang S, Zhang L, Li Z, Xie L, Sun G, Xia Y, et al: Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/β-catenin pathway. J Exp Clin Cancer Res. 40:62021. View Article : Google Scholar | |
Xia Y, Lv J, Jiang T, Li B, Li Y, He Z, Xuan Z, Sun G, Wang S, Li Z, et al: CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated β-catenin stabilization. J Exp Clin Cancer Res. 40:1032021. View Article : Google Scholar | |
Ma Q, Yang F, Huang B, Pan X, Li W, Yu T, Wang X, Ran L, Qian K, Li H, et al: CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA-protein ternary complex. J Exp Clin Cancer Res. 41:2512022. View Article : Google Scholar : PubMed/NCBI | |
Zha Q, Wu X, Zhang J, Xu T, Shi Y, Sun Y, Fang Y, Gu Y, Ma P, Shu Y and Tian S: Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis. Cell Death Discov. 8:1442022. View Article : Google Scholar : PubMed/NCBI | |
Jiang F, Liu G, Chen X, Li Q, Fang F and Shen X: Hsa_circ_0044301 regulates gastric cancer cell's proliferation, migration, and invasion by modulating the Hsa-miR-188-5p/DAXX axis and MAPK pathway. Cancers (Basel). 14:41832022. View Article : Google Scholar : PubMed/NCBI | |
Hou G, Zuo H, Shi J, Dai D, Wang H, Song X, Xu G and Tao G: EIF4A3 induced circABCA5 promotes the gastric cancer progression by SPI1 mediated IL6/JAK2/STAT3 signaling. Am J Cancer Res. 13:602–622. 2023.PubMed/NCBI | |
Li F, Tang H, Zhao S, Gao X, Yang L and Xu J: Circ-E-Cad encodes a protein that promotes the proliferation and migration of gastric cancer via the TGF-β/Smad/C-E-Cad/PI3K/AKT pathway. Mol Carcinog. 62:360–368. 2023. View Article : Google Scholar | |
Zhou P, Qu H, Shi K, Chen X, Zhuang Z, Wang N, Zhang Q, Liu Z, Wang L, Deng K, et al: ATF4-mediated circTDRD3 promotes gastric cancer cell proliferation and metastasis by regulating the miR-891b/ITGA2 axis and AKT signaling pathway. Gastric Cancer. 26:565–579. 2023. View Article : Google Scholar : PubMed/NCBI | |
Peng L, Sang H, Wei S, Li Y, Jin D, Zhu X, Li X, Dang Y and Zhang G: circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2. Mol Cancer. 19:1562020. View Article : Google Scholar : PubMed/NCBI | |
Jie M, Wu Y, Gao M, Li X, Liu C, Ouyang Q, Tang Q, Shan C, Lv Y, Zhang K, et al: CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification. Mol Cancer. 19:562020. View Article : Google Scholar : PubMed/NCBI | |
Ma C, Wang X, Yang F, Zang Y, Liu J, Wang X, Xu X, Li W, Jia J and Liu Z: Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit. Mol Cancer. 19:1572020. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Jiang J, Zhang J, Shen H, Wang M, Guo Z, Zang X, Shi H, Gao J, Cai H, et al: CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability. Mol Cancer. 20:1012021. View Article : Google Scholar : PubMed/NCBI | |
Jiang T, Xia Y, Lv J, Li B, Li Y, Wang S, Xuan Z, Xie L, Qiu S, He Z, et al: A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling. Mol Cancer. 20:662021. View Article : Google Scholar : PubMed/NCBI | |
Zang X, Jiang J, Gu J, Chen Y, Wang M, Zhang Y, Fu M, Shi H, Cai H, Qian H, et al: Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of β-catenin by promoting δ-catenin ubiquitin degradation and upregulating SIK1. Mol Cancer. 21:1412022. View Article : Google Scholar | |
Xu P, Zhang X, Cao J, Yang J, Chen Z, Wang W, Wang S, Zhang L, Xie L, Fang L, et al: The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis. Clin Transl Med. 12:e7072022. View Article : Google Scholar : PubMed/NCBI | |
Zhang C, Wei G, Zhu X, Chen X, Ma X, Hu P, Liu W, Yang W, Ruan T, Zhang W, et al: Exosome-delivered circSTAU2 inhibits the progression of gastric cancer by targeting the miR-589/CAPZA1 axis. Int J Nanomedicine. 18:127–142. 2023. View Article : Google Scholar : PubMed/NCBI | |
Liu H, Fang D, Zhang C, Zhao Z, Liu Y, Zhao S, Zhang N and Xu J: Circular MTHFD2L RNA-encoded CM-248aa inhibits gastric cancer progression by targeting the SET-PP2A interaction. Mol Ther. 31:1739–1755. 2023. View Article : Google Scholar : PubMed/NCBI | |
Liu J, Niu L, Hao J, Yao Y, Yan M and Li H: circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR. Oncogene. 42:980–993. 2023. View Article : Google Scholar : PubMed/NCBI | |
Huang XY, Huang ZL, Huang J, Xu B, Huang XY, Xu YH, Zhou J and Tang ZY: Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis. J Exp Clin Cancer Res. 39:202020. View Article : Google Scholar : PubMed/NCBI | |
Xu J, Wan Z, Tang M, Lin Z, Jiang S, Ji L, Gorshkov K, Mao Q, Xia S, Cen D, et al: N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling. Mol Cancer. 19:1632020. View Article : Google Scholar | |
Zhao Z, Song J, Tang B, Fang S, Zhang D, Zheng L, Wu F, Gao Y, Chen C, Hu X, et al: CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway. J Exp Clin Cancer Res. 39:2592020. View Article : Google Scholar : PubMed/NCBI | |
Wang L, Long H, Zheng Q, Bo X, Xiao X and Li B: Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression. Mol Cancer. 18:1192019. View Article : Google Scholar : PubMed/NCBI | |
Li Q, Pan X, Zhu D, Deng Z, Jiang R and Wang X: Circular RNA MAT2B promotes glycolysis and malignancy of hepatocellular carcinoma through the miR-338-3p/PKM2 axis under hypoxic stress. Hepatology. 70:1298–1316. 2019. View Article : Google Scholar : PubMed/NCBI | |
Liu G, Sun J, Yang ZF, Zhou C, Zhou PY, Guan RY, Sun BY, Wang ZT, Zhou J, Fan J, et al: Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis. Cell Death Dis. 12:2602021. View Article : Google Scholar : PubMed/NCBI | |
Chen Y, Ling Z, Cai X, Xu Y, Lv Z, Man D, Ge J, Yu C, Zhang D, Zhang Y, et al: Activation of YAP1 by N6-methyladenosine-modified circCPSF6 drives malignancy in hepatocellular carcinoma. Cancer Res. 82:599–614. 2022. View Article : Google Scholar | |
Li P, Song R, Yin F, Liu M, Liu H, Ma S, Jia X, Lu X, Zhong Y, Yu L, et al: circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular carcinoma. Mol Ther. 30:431–447. 2022. View Article : Google Scholar : | |
Zheng J, Yan X, Lu T, Song W, Li Y, Liang J, Zhang J, Cai J, Sui X, Xiao J, et al: CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect. J Exp Clin Cancer Res. 42:632023. View Article : Google Scholar : PubMed/NCBI | |
Chen ZQ, Zuo XL, Cai J, Zhang Y, Han GY, Zhang L, Ding WZ, Wu JD and Wang XH: Hypoxia-associated circPRDM4 promotes immune escape via HIF-1α regulation of PD-L1 in hepatocellular carcinoma. Exp Hematol Oncol. 12:172023. View Article : Google Scholar | |
Fan L, Xia P, Wang J, Xu S, Qiu Z, Wu Y, Feng M, Zhao Q, Wang H and Li X: Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC. Mol Carcinog. 62:820–832. 2023. View Article : Google Scholar : PubMed/NCBI | |
Zhu YJ, Zheng B, Luo GJ, Ma XK, Lu XY, Lin XM, Yang S, Zhao Q, Wu T, Li ZX, et al: Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma. Theranostics. 9:3526–3540. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhang PF, Wei CY, Huang XY, Peng R, Yang X, Lu JC, Zhang C, Gao C, Cai JB, Gao PT, et al: Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression. Mol Cancer. 18:1052019. View Article : Google Scholar : PubMed/NCBI | |
Dong ZR, Ke AW, Li T, Cai JB, Yang YF, Zhou W, Shi GM and Fan J: CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity. Mol Cancer. 20:752021. View Article : Google Scholar : PubMed/NCBI | |
Shi L, Liu B, Shen DD, Yan P, Zhang Y, Tian Y, Hou L, Jiang G, Zhu Y, Liang Y, et al: A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancer. Sci Adv. 7:eabe50432021. View Article : Google Scholar : PubMed/NCBI | |
Li J, Hu ZQ, Yu SY, Mao L, Zhou ZJ, Wang PC, Gong Y, Su S, Zhou J, Fan J, et al: CircRPN2 inhibits aerobic glycolysis and metastasis in hepatocellular carcinoma. Cancer Res. 82:1055–1069. 2022. View Article : Google Scholar : PubMed/NCBI | |
Chen S, Cao X, Zhang J, Wu W, Zhang B and Zhao F: circVAMP3 drives CAPRIN1 phase separation and inhibits hepatocellular carcinoma by suppressing c-Myc translation. Adv Sci (Weinh). 9:e21038172022. View Article : Google Scholar : PubMed/NCBI | |
Peng R, Cao J, Su BB, Bai XS, Jin X, Wang AQ, Wang Q, Liu RJ, Jiang GQ, Jin SJ, et al: Down-regulation of circPTTG1IP induces hepatocellular carcinoma development via miR-16-5p/RNF125/JAK1 axis. Cancer Lett. 543:2157782022. View Article : Google Scholar : PubMed/NCBI | |
Guo Z, Xie Q, Wu Y, Mo H, Zhang J, He G, Li Z, Gan L, Feng L, Li T, et al: Aberrant expression of circular RNA DHPR facilitates tumor growth and metastasis by regulating the RASGEF1B/RAS/MAPK axis in hepatocellular carcinoma. Cell Oncol (Dordr). 46:1333–1350. 2023. View Article : Google Scholar : PubMed/NCBI | |
Song R, Ma S, Xu J, Ren X, Guo P, Liu H, Li P, Yin F, Liu M, Wang Q, et al: A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR. Mol Cancer. 22:162023. View Article : Google Scholar : PubMed/NCBI | |
Xu Y, Leng K, Yao Y, Kang P, Liao G, Han Y, Shi G, Ji D, Huang P, Zheng W, et al: A circular RNA, cholangiocarcinoma-associated circular RNA 1, contributes to cholangiocarcinoma progression, induces angiogenesis, and disrupts vascular endothelial barriers. Hepatology. 73:1419–1435. 2021. View Article : Google Scholar | |
Wang S, Hu Y, Lv X, Li B, Gu D, Li Y, Sun Y and Su Y: Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication. Clin Sci (Lond). 133:1935–1953. 2019. View Article : Google Scholar : PubMed/NCBI | |
Zhao X, Zhang X, Zhang Z, Liu Z, Zhu J, Lyu S, Li L, Lang R and He Q: Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma. Aging (Albany NY). 12:23251–23274. 2020.PubMed/NCBI | |
Xu Y, Yao Y, Liu Y, Wang Z, Hu Z, Su Z, Li C, Wang H, Jiang X, Kang P, et al: Elevation of circular RNA circ_0005230 facilitates cell growth and metastasis via sponging miR-1238 and miR-1299 in cholangiocarcinoma. Aging (Albany NY). 11:1907–1917. 2019. View Article : Google Scholar : PubMed/NCBI | |
Xu Y, Gao P, Wang Z, Su Z, Liao G, Han Y, Cui Y, Yao Y and Zhong X: Circ-LAMP1 contributes to the growth and metastasis of cholangiocarcinoma via miR-556-5p and miR-567 mediated YY1 activation. J Cell Mol Med. 25:3226–3238. 2021. View Article : Google Scholar : PubMed/NCBI | |
Tu J, Chen W, Zheng L, Fang S, Zhang D, Kong C, Yang Y, Qiu R, Zhao Z, Lu C, et al: Circular RNA Circ0021205 promotes cholangiocarcinoma progression through MiR-204-5p/RAB22A axis. Front Cell Dev Biol. 9:6532072021. View Article : Google Scholar : PubMed/NCBI | |
Chen Q, Wang H, Li Z, Li F, Liang L, Zou Y, Shen H, Li J, Xia Y, Cheng Z, et al: Circular RNA ACTN4 promotes intrahepatic cholangiocarcinoma progression by recruiting YBX1 to initiate FZD7 transcription. J Hepatol. 76:135–147. 2022. View Article : Google Scholar | |
Zhong X, Ji C, Ren D, Ke A and Yang Z: Circular RNA circEIF3C promotes intrahepatic cholangiocarcinoma progression and immune evasion via the miR-34a-5p/B7-H4 axis. Genes Dis. 10:370–372. 2022. View Article : Google Scholar | |
Li H, Lan T, Liu H, Liu C, Dai J, Xu L, Cai Y, Hou G, Xie K, Liao M, et al: IL-6-induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma. Hepatology. 75:1402–1419. 2022. View Article : Google Scholar | |
Yu X, Tong H, Chen J, Tang C, Wang S, Si Y, Wang S and Tang Z: CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export. Cell Death Dis. 14:202023. View Article : Google Scholar : PubMed/NCBI | |
Liao W, Du J, Li L, Wu X, Chen X, Feng Q, Xu L, Chen X, Liao M, Huang J, et al: CircZNF215 promotes tumor growth and metastasis through inactivation of the PTEN/AKT pathway in intrahepatic cholangiocarcinoma. J Exp Clin Cancer Res. 42:1252023. View Article : Google Scholar : PubMed/NCBI | |
Du J, Lan T, Liao H, Feng X, Chen X, Liao W, Hou G, Xu L, Feng Q, Xie K, et al: CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma. Mol Cancer. 21:182022. View Article : Google Scholar : PubMed/NCBI | |
Zhang X, Zhao Y, Wang W, Yu S, Liu L, Sun D, Li W and Jiang X: Upregulation of circ_0059961 suppresses cholangiocarcinoma development by modulating miR-629-5p/SFRP2 axis. Pathol Res Pract. 234:1539012022. View Article : Google Scholar : PubMed/NCBI | |
Wang G, Gao X, Sun Z, He T, Huang C, Li S and Long H: Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis. Anticancer Drugs. 34:1002–1009. 2023. View Article : Google Scholar : PubMed/NCBI | |
Li J, Li Z, Jiang P, Peng M, Zhang X, Chen K, Liu H, Bi H, Liu X and Li X: Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis. J Exp Clin Cancer Res. 37:1772018. View Article : Google Scholar : PubMed/NCBI | |
Wong CH, Lou UK, Li Y, Chan SL, Tong JH, To KF and Chen Y: CircFOXK2 promotes growth and metastasis of pancreatic ductal adenocarcinoma by complexing with RNA-binding proteins and sponging MiR-942. Cancer Res. 80:2138–2149. 2020. View Article : Google Scholar : PubMed/NCBI | |
Guo X, Zhou Q, Su D, Luo Y, Fu Z, Huang L, Li Z, Jiang D, Kong Y, Li Z, et al: Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis. Mol Cancer. 19:832020. View Article : Google Scholar : PubMed/NCBI | |
Ye Z, Zhu Z, Xie J, Feng Z, Li Y, Xu X, Li W and Chen W: Hsa_circ_0000069 knockdown inhibits tumorigenesis and exosomes with downregulated hsa_circ_0000069 suppress malignant transformation via inhibition of STIL in pancreatic cancer. Int J Nanomedicine. 15:9859–9873. 2020. View Article : Google Scholar : PubMed/NCBI | |
Zhou X, Liu K, Cui J, Xiong J, Wu H, Peng T and Guo Y: Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer. J Exp Clin Cancer Res. 40:1242021. View Article : Google Scholar : PubMed/NCBI | |
Rong Z, Shi S, Tan Z, Xu J, Meng Q, Hua J, Liu J, Zhang B, Wang W, Yu X and Liang C: Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294/c-Myc axis. Mol Cancer. 20:1062021. View Article : Google Scholar : PubMed/NCBI | |
Zeng Z, Zhao Y, Chen Q, Zhu S, Niu Y, Ye Z, Hu P, Chen D, Xu P, Chen J, et al: Hypoxic exosomal HIF-1α-stabilizing circZNF91 promotes chemoresistance of normoxic pancreatic cancer cells via enhancing glycolysis. Oncogene. 40:5505–5517. 2021. View Article : Google Scholar : PubMed/NCBI | |
Lin J, Wang X, Zhai S, Shi M, Peng C, Deng X, Fu D, Wang J and Shen B: Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1. J Hematol Oncol. 15:1282022. View Article : Google Scholar : PubMed/NCBI | |
He Z, Cai K, Zeng Z, Lei S, Cao W and Li X: Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression. Cell Death Dis. 13:2332022. View Article : Google Scholar : PubMed/NCBI | |
Hu C, Xia R, Zhang X, Li T, Ye Y, Li G, He R, Li Z, Lin Q, Zheng S and Chen R: circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis. Mol Cancer. 21:242022. View Article : Google Scholar : PubMed/NCBI | |
Guan H, Tian K, Luo W and Li M: m6A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m6A/PD-L1 manner. Cell Death Dis. 14:1202023. View Article : Google Scholar | |
Liu B, Gong Y, Jiang Q, Wu S, Han B, Chen F, Lin Q, Wang P and Yang D: Hsa_circ_0014784-induced YAP1 promoted the progression of pancreatic cancer by sponging miR-214-3p. Cell Cycle. 22:1583–1596. 2023. View Article : Google Scholar : PubMed/NCBI | |
Kong Y, Li Y, Luo Y, Zhu J, Zheng H, Gao B, Guo X, Li Z, Chen R and Chen C: circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer. Mol Cancer. 19:822020. View Article : Google Scholar : PubMed/NCBI | |
Huang L, Han J, Yu H, Liu J, Gui L, Wu Z, Zhao X, Su S, Fu G and Li F: CircRNA_000864 upregulates B-cell translocation gene 2 expression and represses migration and invasion in pancreatic cancer cells by binding to miR-361-3p. Front Oncol. 10:5479422020. View Article : Google Scholar | |
Xu H, Chen R, Shen Q, Yang D, Peng H, Tong J and Fu Q: Overexpression of circular RNA circ_0013587 reverses erlotinib resistance in pancreatic cancer cells through regulating the miR-1227/E-cadherin pathway. Front Oncol. 11:7541462021. View Article : Google Scholar : PubMed/NCBI | |
Yu S, Wang M, Zhang H, Guo X and Qin R: Circ_0092367 inhibits EMT and gemcitabine resistance in pancreatic cancer via regulating the miR-1206/ESRP1 axis. Genes (Basel). 12:17012021. View Article : Google Scholar : PubMed/NCBI | |
Shi X, Yang J, Liu M, Zhang Y, Zhou Z, Luo W, Fung KM, Xu C, Bronze MS, Houchen CW and Li M: Circular RNA ANAPC7 inhibits tumor growth and muscle wasting via PHLPP2-AKT-TGF-β signaling axis in pancreatic cancer. Gastroenterology. 162:2004–2017.e2. 2022. View Article : Google Scholar | |
Liu J, Yuan W and Gong D: Hsa_circ_0000994 inhibits pancreatic cancer progression by clearing immune-related miR-27a and miR-27b. J Oncol. 2022:72747942022.PubMed/NCBI | |
Xu C, Ye Q, Ye C and Liu S: circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway. Biol Direct. 18:142023. View Article : Google Scholar : PubMed/NCBI | |
Chen RX, Chen X, Xia LP, Zhang JX, Pan ZZ, Ma XD, Han K, Chen JW, Judde JG, Deas O, et al: N(6)-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis. Nat Commun. 10:46952019. View Article : Google Scholar : PubMed/NCBI | |
Shang A, Gu C, Wang W, Wang X, Sun J, Zeng B, Chen C, Chang W, Ping Y, Ji P, et al: Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p-TGF-β1 axis. Mol Cancer. 19:1172020. View Article : Google Scholar | |
Chen LY, Wang L, Ren YX, Pang Z, Liu Y, Sun XD, Tu J, Zhi Z, Qin Y, Sun LN and Li JM: The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1α translation. Mol Cancer. 19:1642020. View Article : Google Scholar | |
Xu H, Liu Y, Cheng P, Wang C, Liu Y, Zhou W, Xu Y and Ji G: CircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis. J Exp Clin Cancer Res. 39:2832020. View Article : Google Scholar : PubMed/NCBI | |
Chen C, Yuan W, Zhou Q, Shao B, Guo Y, Wang W, Yang S, Guo Y, Zhao L, Dang Q, et al: N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization. Theranostics. 11:4298–4315. 2021. View Article : Google Scholar : PubMed/NCBI | |
Wang J, Zhang Y, Song H, Yin H, Jiang T, Xu Y, Liu L, Wang H, Gao H, Wang R and Song J: The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway. Mol Cancer. 20:812021. View Article : Google Scholar : PubMed/NCBI | |
Liu Z, Zheng N, Li J, Li C, Zheng D, Jiang X, Ge X, Liu M, Liu L, Song Z, et al: N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells. Drug Resist Updat. 65:1008862022. View Article : Google Scholar : PubMed/NCBI | |
Chen Z, He L, Zhao L, Zhang G, Wang Z, Zhu P and Liu B: circREEP3 drives colorectal cancer progression via activation of FKBP10 transcription and restriction of antitumor immunity. Adv Sci (Weinh). 9:e21051602022. View Article : Google Scholar : PubMed/NCBI | |
Yang Y, Luo D, Shao Y, Shan Z, Liu Q, Weng J, He W, Zhang R, Li Q, Wang Z and Li X: circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer. Cancer Commun (Lond). 43:100–122. 2023. View Article : Google Scholar | |
Chen C, Liu Y, Liu L, Si C, Xu Y, Wu X, Wang C, Sun Z and Kang Q: Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway. J Exp Clin Cancer Res. 42:462023. View Article : Google Scholar : PubMed/NCBI | |
Li Z, Yao H, Wang S, Li G and Gu X: CircTADA2A suppresses the progression of colorectal cancer via miR-374a-3p/KLF14 axis. J Exp Clin Cancer Res. 39:1602020. View Article : Google Scholar : PubMed/NCBI | |
Peng C, Tan Y, Yang P, Jin K, Zhang C, Peng W, Wang L, Zhou J, Chen R, Wang T, et al: Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK. J Exp Clin Cancer Res. 40:2722021. View Article : Google Scholar : PubMed/NCBI | |
Chen J, Wu Y, Luo X, Jin D, Zhou W, Ju Z, Wang D, Meng Q, Wang H, Fu X, et al: Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer. Theranostics. 11:7507–7526. 2021. View Article : Google Scholar : PubMed/NCBI | |
Liang ZX, Liu HS, Xiong L, Yang X, Wang FW, Zeng ZW, He XW, Wu XR and Lan P: A novel NF-κB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation. Mol Cancer. 20:1032021. View Article : Google Scholar | |
Zheng R, Zhang K, Tan S, Gao F, Zhang Y, Xu W, Wang H, Gu D, Zhu L, Li S, et al: Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction. Mol Cancer. 21:492022. View Article : Google Scholar : PubMed/NCBI | |
Zhang F, Su T and Xiao M: RUNX3-regulated circRNA METTL3 inhibits colorectal cancer proliferation and metastasis via miR-107/PER3 axis. Cell Death Dis. 13:5502022. View Article : Google Scholar : PubMed/NCBI | |
Ding N, You AB, Yang H, Hu GS, Lai CP, Liu W and Ye F: A Tumor-suppressive molecular axis EP300/circRERE/miR-6837-3p/MAVS activates type I IFN pathway and antitumor immunity to suppress colorectal cancer. Clin Cancer Res. 29:2095–2109. 2023. View Article : Google Scholar : PubMed/NCBI | |
Xia S, Feng J, Chen K, Ma Y, Gong J, Cai F, Jin Y, Gao Y, Xia L, Chang H, et al: CSCD: A database for cancer-specific circular RNAs. Nucleic Acids Res. 46(D1): D925–D929. 2018. View Article : Google Scholar : | |
Tan LP, Seinen E, Duns G, de Jong D, Sibon OC, Poppema S, Kroesen BJ, Kok K and van den Berg A: A high throughput experimental approach to identify miRNA targets in human cells. Nucleic Acids Res. 37:e1372009. View Article : Google Scholar : PubMed/NCBI | |
Chou CH, Shrestha S, Yang CD, Chang NW, Lin YL, Liao KW, Huang WC, Sun TH, Tu SJ, Lee WH, et al: miRTarBase update 2018: A resource for experimentally validated microRNA-target interactions. Nucleic Acids Res. 46(D1): D296–D302. 2018. View Article : Google Scholar : | |
Wong N and Wang X: miRDB: An online resource for microRNA target prediction and functional annotations. Nucleic Acids Res. 43(Database Issue): D146–D152. 2015. View Article : Google Scholar : | |
Cai S, Zhang Y, Zhang X, Wang L, Wu Z, Fang W and Chen X: A microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma. J Gastrointest Oncol. 13:510–526. 2022. View Article : Google Scholar : PubMed/NCBI | |
Zhang Y, Li J, Yu J, Liu H, Shen Z, Ye G, Mou T, Qi X and Li G: Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery. Oncotarget. 8:22936–22943. 2017. View Article : Google Scholar : PubMed/NCBI | |
Han J, Thurnherr T, Chung AYF, Goh BKP, Chow PKH, Chan CY, Cheow PC, Lee SY, Lim TKH, Chong SS, et al: Clinicopathological-associated regulatory network of deregulated circRNAs in hepatocellular carcinoma. Cancers (Basel). 13:27722021. View Article : Google Scholar : PubMed/NCBI | |
Han D, Li J, Wang H, Su X, Hou J, Gu Y, Qian C, Lin Y, Liu X, Huang M, et al: Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression. Hepatology. 66:1151–1164. 2017. View Article : Google Scholar : PubMed/NCBI | |
Li H, Hao X, Wang H, Liu Z, He Y, Pu M, Zhang H, Yu H, Duan J and Qu S: Circular RNA expression profile of pancreatic ductal adenocarcinoma revealed by microarray. Cell Physiol Biochem. 40:1334–1344. 2016. View Article : Google Scholar : PubMed/NCBI | |
Qu S, Song W, Yang X, Wang J, Zhang R, Zhang Z, Zhang H and Li H: Microarray expression profile of circular RNAs in human pancreatic ductal adenocarcinoma. Genom Data. 5:385–387. 2015. View Article : Google Scholar : PubMed/NCBI | |
Guo S, Xu X, Ouyang Y, Wang Y, Yang J, Yin L, Ge J and Wang H: Microarray expression profile analysis of circular RNAs in pancreatic cancer. Mol Med Rep. 17:7661–7671. 2018.PubMed/NCBI | |
Yang H, Li X, Meng Q, Sun H, Wu S, Hu W, Liu G, Li X, Yang Y and Chen R: CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer. Mol Cancer. 19:132020. View Article : Google Scholar : PubMed/NCBI |