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Beyond self‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)

  • Authors:
    • Giulia Tedesco
    • Manuela Santarosa
    • Roberta Maestro
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  • Published online on: April 10, 2024     https://doi.org/10.3892/ijo.2024.5645
  • Article Number: 57
  • Copyright: © Tedesco et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Autophagy is a conserved catabolic process that controls organelle quality, removes misfolded or abnormally aggregated proteins and is part of the defense mechanisms against intracellular pathogens. Autophagy contributes to the suppression of tumor initiation by promoting genome stability, cellular integrity, redox balance and proteostasis. On the other hand, once a tumor is established, autophagy can support cancer cell survival and promote epithelial‑to‑mesenchymal transition. A growing number of molecules involved in autophagy have been identified. In addition to their key canonical activity, several of these molecules, such as ATG5, ATG12 and Beclin‑1, also exert autophagy‑independent functions in a variety of biological processes. The present review aimed to summarize autophagy‑independent functions of molecules of the autophagy machinery and how the activity of these molecules can influence signaling pathways that are deregulated in cancer progression.
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June-2024
Volume 64 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Tedesco G, Santarosa M and Maestro R: Beyond self‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review). Int J Oncol 64: 57, 2024.
APA
Tedesco, G., Santarosa, M., & Maestro, R. (2024). Beyond self‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review). International Journal of Oncology, 64, 57. https://doi.org/10.3892/ijo.2024.5645
MLA
Tedesco, G., Santarosa, M., Maestro, R."Beyond self‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)". International Journal of Oncology 64.6 (2024): 57.
Chicago
Tedesco, G., Santarosa, M., Maestro, R."Beyond self‑eating: Emerging autophagy‑independent functions for the autophagy molecules in cancer (Review)". International Journal of Oncology 64, no. 6 (2024): 57. https://doi.org/10.3892/ijo.2024.5645