Open Access

Decoding long non‑coding RNAs: Friends and foes in cancer development (Review)

  • This article is part of the special Issue: Long non-coding RNAs and cancer: implications for diagnosis, prognosis and treatment
  • Authors:
    • Hequn Song
    • Joseph Adu-Amankwaah
    • Qizhong Zhao
    • Dongqi Yang
    • Kuntao Liu
    • Aisha Bushi
    • Jinming Zhao
    • Jinxiang Yuan
    • Rubin Tan
  • View Affiliations

  • Published online on: May 1, 2024     https://doi.org/10.3892/ijo.2024.5649
  • Article Number: 61
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer remains a formidable adversary, challenging medical advancements with its dismal prognosis, low cure rates and high mortality rates. Within this intricate landscape, long non‑coding RNAs (lncRNAs) emerge as pivotal players, orchestrating proliferation and migration of cancer cells. Harnessing the potential of lncRNAs as therapeutic targets and prognostic markers holds immense promise. The present comprehensive review delved into the molecular mechanisms underlying the involvement of lncRNAs in the onset and progression of the top five types of cancer. By meticulously examining lncRNAs across diverse types of cancer, it also uncovered their distinctive roles, highlighting their exclusive oncogenic effects or tumor suppressor properties. Notably, certain lncRNAs demonstrate diverse functions across different cancers, confounding the conventional understanding of their roles. Furthermore, the present study identified lncRNAs exhibiting aberrant expression patterns in numerous types of cancer, presenting them as potential indicators for cancer screening and diagnosis. Conversely, a subset of lncRNAs manifests tissue‑specific expression, hinting at their specialized nature and untapped significance in diagnosing and treating specific types of cancer. The present comprehensive review not only shed light on the intricate network of lncRNAs but also paved the way for further research and clinical applications. The unraveled molecular mechanisms offer a promising avenue for targeted therapeutics and personalized medicine, combating cancer proliferation, invasion and metastasis.
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June-2024
Volume 64 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Song H, Adu-Amankwaah J, Zhao Q, Yang D, Liu K, Bushi A, Zhao J, Yuan J and Tan R: Decoding long non‑coding RNAs: Friends and foes in cancer development (Review). Int J Oncol 64: 61, 2024.
APA
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A. ... Tan, R. (2024). Decoding long non‑coding RNAs: Friends and foes in cancer development (Review). International Journal of Oncology, 64, 61. https://doi.org/10.3892/ijo.2024.5649
MLA
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A., Zhao, J., Yuan, J., Tan, R."Decoding long non‑coding RNAs: Friends and foes in cancer development (Review)". International Journal of Oncology 64.6 (2024): 61.
Chicago
Song, H., Adu-Amankwaah, J., Zhao, Q., Yang, D., Liu, K., Bushi, A., Zhao, J., Yuan, J., Tan, R."Decoding long non‑coding RNAs: Friends and foes in cancer development (Review)". International Journal of Oncology 64, no. 6 (2024): 61. https://doi.org/10.3892/ijo.2024.5649