Open Access

Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review)

  • Authors:
    • Shenghao Li
    • Liyuan Hao
    • Na Li
    • Xiaoyu Hu
    • Huimin Yan
    • Erhei Dai
    • Xinli Shi
  • View Affiliations

  • Published online on: July 31, 2024     https://doi.org/10.3892/ijo.2024.5676
  • Article Number: 88
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The Hippo signaling pathway plays a pivotal role in regulating cell growth and organ size. Its regulatory effects on hepatocellular carcinoma (HCC) encompass diverse aspects, including cell proliferation, invasion and metastasis, tumor drug resistance, metabolic reprogramming, immunomodulatory effects and autophagy. Yes‑associated protein 1 (YAP1), a potent transcriptional coactivator and a major downstream target tightly controlled by the Hippo pathway, is influenced by various molecules and pathways. The expression of YAP1 in different cell types within the liver tumor microenvironment exerts varying effects on tumor outcomes, warranting careful consideration. Therefore, research on YAP1‑targeted therapies merits attention. This review discusses the composition and regulation mechanism of the Hippo/YAP1 signaling pathway and its relationship with HCC, offering insights for future research and cancer prevention strategies.
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September-2024
Volume 65 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Li S, Hao L, Li N, Hu X, Yan H, Dai E and Shi X: Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review). Int J Oncol 65: 88, 2024.
APA
Li, S., Hao, L., Li, N., Hu, X., Yan, H., Dai, E., & Shi, X. (2024). Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review). International Journal of Oncology, 65, 88. https://doi.org/10.3892/ijo.2024.5676
MLA
Li, S., Hao, L., Li, N., Hu, X., Yan, H., Dai, E., Shi, X."Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review)". International Journal of Oncology 65.3 (2024): 88.
Chicago
Li, S., Hao, L., Li, N., Hu, X., Yan, H., Dai, E., Shi, X."Targeting the Hippo/YAP1 signaling pathway in hepatocellular carcinoma: From mechanisms to therapeutic drugs (Review)". International Journal of Oncology 65, no. 3 (2024): 88. https://doi.org/10.3892/ijo.2024.5676