Alterations in mitochondria function and morphology in HT29 cells upon conditions inducing differentiation and apoptosis
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- Published online on: December 1, 2003 https://doi.org/10.3892/ijo.23.6.1755
- Pages: 1755-1760
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Abstract
Morphological and biochemical studies of HT29 cells treated with sodium butyrate and/or glucose-deprived revealed both apoptotic and differentiation response. The main apoptotic response was accompanied with an increase of floating cells. However, the ultrastructural analysis of adherent cells showed the typical apoptotic character of the nucleus in some of them. In addition, remarkable changes of mitochondria, assumed as early stages starting the apoptotic cascade, were observed. These changes were represented not only by alterations of mitochondrial morphology, but also by the number of mitochondria and their localization.