POSSIBLE ASSOCIATION OF NM23 GENE-EXPRESSION AND KI-RAS POINT MUTATIONS WITH METASTATIC POTENTIAL IN HUMAN PANCREATIC CANCER-DERIVED CELL-LINES
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- Published online on: October 1, 1993 https://doi.org/10.3892/ijo.3.4.641
- Pages: 641-644
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Abstract
Nm23 gene expression and Ki-ras point mutations of eight human pancreatic cancer-derived cell lines with different metastatic capabilities were studied. Nm23 gene expression was significantly reduced in the cell lines with a high metastatic potential as compared with those with a low meta static potential (p<0.05). The same mutation at codon 12 of the Ki-ras gene (Gly12 to Asp12) was found in all cell lines with a high metastatic potential. These findings suggest a possible association of metastatic potential with Nm23 gene expression as well as the mutation of Ki-ras gene in human pancreatic cancer.
