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P-GLYCOPROTEIN EXPRESSION, TUMOR DIFFERENTIATION, CHEMOSENSITIVITY OF TUMOR-CELLS IN-VITRO AND CLINICAL OUTCOME IN PATIENTS WITH RENAL-CELL CARCINOMA

  • Authors:
    • T LAI
    • R ANGUS
    • CMP COLLINS
    • RCL FENELEY
    • GN SIBLEY
    • PJB SMITH
    • BR STONEBRIDGE
    • MO SYMES

  • View Affiliations

  • Published online on: January 1, 1994     https://doi.org/10.3892/ijo.4.1.211
  • Pages: 211-213
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Abstract

There was no association between expression of P-170 glycoprotein on cells derived from 14 renal carcinomas and the in vitro sensitivity of the cells to doxorubicin or its potentiation by verapamil. Furthermore expression of P-170 on the cells of individual tumours was unrelated to nuclear differentiation or patient prognosis. These observations may in part resolve the dilemma posed by the reported association in some tumour types between expression of P-170 and the metastatic phenotype together with the previously observed relation in renal carcinoma between P-170 expression, good tumour differentiation and therefore a favourable prognosis.

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January 1994
Volume 4 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
LAI T, ANGUS R, COLLINS C, FENELEY R, SIBLEY G, SMITH P, STONEBRIDGE B and SYMES M: P-GLYCOPROTEIN EXPRESSION, TUMOR DIFFERENTIATION, CHEMOSENSITIVITY OF TUMOR-CELLS IN-VITRO AND CLINICAL OUTCOME IN PATIENTS WITH RENAL-CELL CARCINOMA. Int J Oncol 4: 211-213, 1994.
APA
LAI, T., ANGUS, R., COLLINS, C., FENELEY, R., SIBLEY, G., SMITH, P. ... SYMES, M. (1994). P-GLYCOPROTEIN EXPRESSION, TUMOR DIFFERENTIATION, CHEMOSENSITIVITY OF TUMOR-CELLS IN-VITRO AND CLINICAL OUTCOME IN PATIENTS WITH RENAL-CELL CARCINOMA. International Journal of Oncology, 4, 211-213. https://doi.org/10.3892/ijo.4.1.211
MLA
LAI, T., ANGUS, R., COLLINS, C., FENELEY, R., SIBLEY, G., SMITH, P., STONEBRIDGE, B., SYMES, M."P-GLYCOPROTEIN EXPRESSION, TUMOR DIFFERENTIATION, CHEMOSENSITIVITY OF TUMOR-CELLS IN-VITRO AND CLINICAL OUTCOME IN PATIENTS WITH RENAL-CELL CARCINOMA". International Journal of Oncology 4.1 (1994): 211-213.
Chicago
LAI, T., ANGUS, R., COLLINS, C., FENELEY, R., SIBLEY, G., SMITH, P., STONEBRIDGE, B., SYMES, M."P-GLYCOPROTEIN EXPRESSION, TUMOR DIFFERENTIATION, CHEMOSENSITIVITY OF TUMOR-CELLS IN-VITRO AND CLINICAL OUTCOME IN PATIENTS WITH RENAL-CELL CARCINOMA". International Journal of Oncology 4, no. 1 (1994): 211-213. https://doi.org/10.3892/ijo.4.1.211