TRANSFORMING GROWTH-FACTOR-ALPHA AND FACTOR-BETA(1) LEVELS IN PLASMA AND EFFUSIONS FROM PATIENTS WITH CANCER OR HEMATOLOGIC MALIGNANCIES
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- Published online on: April 1, 1994 https://doi.org/10.3892/ijo.4.4.943
- Pages: 943-950
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Abstract
Transforming growth factors-alpha and -beta1 are thought to play a role in carcinogenesis. Using a sandwich linked immunosorbent assay, we have measured TGF-alpha and -beta1 levels in malignant human plasma and effusions. TGF-alpha and -beta1 plasma levels were not significantly different among normal volunteers, patients with solid tumors, and patients with hematologic malignancies (TGF-alpha, p=0.225; TGF-beta1, p=0.354). Statistically significant differences were also not found in levels between malignant and non-malignant effusions (TGF-alpha, p=0.327; TGF-beta1, p=0.095). However, a trend for the majority of elevated TGF-alpha or TGF-beta1 levels to be in malignant effusions warrants further studies with larger numbers of samples.