GENETIC STABILITY OF MICROSATELLITES IN HUMAN NEUROBLASTOMAS
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- Published online on: May 1, 1994 https://doi.org/10.3892/ijo.4.5.1043
- Pages: 1043-1045
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Abstract
Genetic instability resulting from deficiency in replication error repair (RER) has been detected in a variety of human cancers. We have examined the stability of five 1p microsatellites in 51 human neuroblastomas including stages 1, 2, 3, 4 and 4s. None of the tumors showed an aberrant pattern indicating RER at any microsatellite. Our results do not support a major role for increased genetic instability as the result of deficient replication error repair in neuroblastoma.