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THE EFFECTS OF RETINOIC ACID ANALOGS ON THE BLAST CELLS OF ACUTE MYELOBLASTIC-LEUKEMIA IN CULTURE

  • Authors:
    • S TOHDA
    • K SHUDO
    • MD MINDEN

  • View Affiliations

  • Published online on: June 1, 1994     https://doi.org/10.3892/ijo.4.6.1311
  • Pages: 1311-1314
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The effects of retinoic acid (RA) analogues, Am80 and Ch55, on acute myeloblastic leukemia (AML) cells, acute promyelocytic leukemia (APL) cells, and normal bone marrow (BM) cells, were studied in vitro. These analogues have different binding affinity to RA receptors and cellular retinoic acid binding proteins (CRABP). All-trans RA (ATRA) showed various effects on the proliferation of AML cells and BM cells. These analogues showed similar effects. Regarding the differentiation of APL cells into neutrophils, Ch55 and Am80 were more potent than ATRA. Ch55, which does not bind to CRABP, may overcome the clinical problem of retinoid-resistance due to the induction of CRABP.

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June 1994
Volume 4 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
  • Ranked Oncology
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
TOHDA S, SHUDO K and MINDEN M: THE EFFECTS OF RETINOIC ACID ANALOGS ON THE BLAST CELLS OF ACUTE MYELOBLASTIC-LEUKEMIA IN CULTURE. Int J Oncol 4: 1311-1314, 1994.
APA
TOHDA, S., SHUDO, K., & MINDEN, M. (1994). THE EFFECTS OF RETINOIC ACID ANALOGS ON THE BLAST CELLS OF ACUTE MYELOBLASTIC-LEUKEMIA IN CULTURE. International Journal of Oncology, 4, 1311-1314. https://doi.org/10.3892/ijo.4.6.1311
MLA
TOHDA, S., SHUDO, K., MINDEN, M."THE EFFECTS OF RETINOIC ACID ANALOGS ON THE BLAST CELLS OF ACUTE MYELOBLASTIC-LEUKEMIA IN CULTURE". International Journal of Oncology 4.6 (1994): 1311-1314.
Chicago
TOHDA, S., SHUDO, K., MINDEN, M."THE EFFECTS OF RETINOIC ACID ANALOGS ON THE BLAST CELLS OF ACUTE MYELOBLASTIC-LEUKEMIA IN CULTURE". International Journal of Oncology 4, no. 6 (1994): 1311-1314. https://doi.org/10.3892/ijo.4.6.1311