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ESTABLISHMENT AND CHARACTERIZATION OF PTHRP-PRODUCING HUMAN PANCREATIC-CANCER CELL-LINE

  • Authors:
    • Y NISHI
    • M HAJI
    • R TAKAYANAGI
    • H IGUCHI
    • T SHIMAZOE
    • J HIRATA
    • H NAWATA

  • View Affiliations

  • Published online on: July 1, 1994     https://doi.org/10.3892/ijo.5.1.33
  • Pages: 33-39
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

Human pancreatic ductal cell carcinoma cell line, which can secrete parathyroid hormone-related peptide (PTHrP), designated as KP 4, and its daughter cell lines with different PTHrP-secreting activities, termed KP 4-1 and KP 4-2, have been established in tissue culture. KP 4 cells were able to form tumors in nude mice. The absolute production rate of PTHrP in KP 4-1 was 5 to 10 times higher than that in KP 4-2. Similarly, the level of PTHrP mRNA in KP 4-1 was significantly higher than that in KP 4-2. KP 4-2 cells exhibited more rapid growth than KP 4 and KP 4-1 in vitro. Our established cell lines should provide a useful system to study the regulation of PTHrP production and its pathophysiological roles.

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July 1994
Volume 5 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
  • Ranked Oncology
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
NISHI Y, HAJI M, TAKAYANAGI R, IGUCHI H, SHIMAZOE T, HIRATA J and NAWATA H: ESTABLISHMENT AND CHARACTERIZATION OF PTHRP-PRODUCING HUMAN PANCREATIC-CANCER CELL-LINE. Int J Oncol 5: 33-39, 1994.
APA
NISHI, Y., HAJI, M., TAKAYANAGI, R., IGUCHI, H., SHIMAZOE, T., HIRATA, J., & NAWATA, H. (1994). ESTABLISHMENT AND CHARACTERIZATION OF PTHRP-PRODUCING HUMAN PANCREATIC-CANCER CELL-LINE. International Journal of Oncology, 5, 33-39. https://doi.org/10.3892/ijo.5.1.33
MLA
NISHI, Y., HAJI, M., TAKAYANAGI, R., IGUCHI, H., SHIMAZOE, T., HIRATA, J., NAWATA, H."ESTABLISHMENT AND CHARACTERIZATION OF PTHRP-PRODUCING HUMAN PANCREATIC-CANCER CELL-LINE". International Journal of Oncology 5.1 (1994): 33-39.
Chicago
NISHI, Y., HAJI, M., TAKAYANAGI, R., IGUCHI, H., SHIMAZOE, T., HIRATA, J., NAWATA, H."ESTABLISHMENT AND CHARACTERIZATION OF PTHRP-PRODUCING HUMAN PANCREATIC-CANCER CELL-LINE". International Journal of Oncology 5, no. 1 (1994): 33-39. https://doi.org/10.3892/ijo.5.1.33