search button

TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID

  • Authors:
    • DJH ROBERTS
    • F CAIRNDUFF
    • I DRIVER
    • B DIXON
    • SB BROWN

  • View Affiliations

  • Published online on: October 1, 1994     https://doi.org/10.3892/ijo.5.4.763
  • Pages: 763-768
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The effects of photodynamic therapy (PDT) based on polyhaematoporphyrin (PHP) or 5-aminolaevulinic acid (ALA) on the tumour vascular perfusion (TVP) of a rat fibrosarcoma were examined using an (RbCl)-Rb-86 extraction technique. Both forms of therapy induced large and highly significant reductions in TVP, countering the previous suggestion that ALA-PDT has no vascular effects. Ultrasensitive digital imaging fluorescence microscopy indicated that ALA-induced PpIX was distributed relatively evenly throughout the tumour. Use of Hoechst 33342 as a vascular marker revealed that PpIX was also present in cells lining the tumour microvascular spaces, contrary to previous findings.

Related Articles

Journal Cover

October 1994
Volume 5 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 4.5
  • Ranked Oncology
    (total number of cites)
  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
ROBERTS D, CAIRNDUFF F, DRIVER I, DIXON B and BROWN S: TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID. Int J Oncol 5: 763-768, 1994.
APA
ROBERTS, D., CAIRNDUFF, F., DRIVER, I., DIXON, B., & BROWN, S. (1994). TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID. International Journal of Oncology, 5, 763-768. https://doi.org/10.3892/ijo.5.4.763
MLA
ROBERTS, D., CAIRNDUFF, F., DRIVER, I., DIXON, B., BROWN, S."TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID". International Journal of Oncology 5.4 (1994): 763-768.
Chicago
ROBERTS, D., CAIRNDUFF, F., DRIVER, I., DIXON, B., BROWN, S."TUMOR VASCULAR SHUTDOWN FOLLOWING PHOTODYNAMIC THERAPY BASED ON POLYHEMATOPORPHYRIN OR 5-AMINOLEVULINIC ACID". International Journal of Oncology 5, no. 4 (1994): 763-768. https://doi.org/10.3892/ijo.5.4.763