VASCULAR ENDOTHELIAL GROWTH-FACTOR EXPRESSION AND ANGIOGENESIS IN NONSMALL CELL LUNG CARCINOMAS
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- Published online on: May 1, 1995 https://doi.org/10.3892/ijo.6.5.1059
- Pages: 1059-1062
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Abstract
Vascular endothelial growth factor (VEGF), a secreted endothelial-specific growth factor, and microvessel density was examined in 204 primary non-small cell lung carcinomas. The expression of VEGF was evaluated by immunohistochemical staining using an anti-VEGF antibody. Positive staining was obtained in 125 out of 204 cases (61%). Tumor vascularity was quantitatively assessed by microvessel counting after staining with the endothelial-specific marker factor VIII. The mean microvessel count for all patients was 9.6+/-10.4. Expression of VEGF was closely associated with increment of microvessel density. Postoperative follow-up of patients demonstrated a trend that survival time of patients with VEGF-positive tumors was worse than that of patients with VEGF-negative tumors. In contrast, microvessel density was not a prognostic factor.