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LACK OF MICROSATELLITE INSTABILITY IN HUMAN PROSTATE-CANCER

  • Authors:
    • FC CHRISTIANS
    • D CONNOLLY
    • K TSUCHIYA
    • LD TRUE
    • LA LOEB

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  • Published online on: June 1, 1995     https://doi.org/10.3892/ijo.6.6.1173
  • Pages: 1173-1176
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

DNA replication errors are especially frequent in repetitive DNA sequences, including microsatellites. Thus, microsatellites are sensitive indicators of the genetic instability observed in many types of human cancers, particularly colorectal cancer. We tested prostate carcinomas for the presence of microsatellite alleles not present in normal tissue from the same individuals. Analysis of 7 microsatellites in each of 30 patients revealed instability at only one microsatellite in one tumor. This level of microsatellite instability, considerably lower than that reported previously, may reflect differences in patient pools. We discuss the implications of the genetic stability of prostate cancers relative to other cancers.

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June 1995
Volume 6 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
CHRISTIANS F, CONNOLLY D, TSUCHIYA K, TRUE L and LOEB L: LACK OF MICROSATELLITE INSTABILITY IN HUMAN PROSTATE-CANCER. Int J Oncol 6: 1173-1176, 1995.
APA
CHRISTIANS, F., CONNOLLY, D., TSUCHIYA, K., TRUE, L., & LOEB, L. (1995). LACK OF MICROSATELLITE INSTABILITY IN HUMAN PROSTATE-CANCER. International Journal of Oncology, 6, 1173-1176. https://doi.org/10.3892/ijo.6.6.1173
MLA
CHRISTIANS, F., CONNOLLY, D., TSUCHIYA, K., TRUE, L., LOEB, L."LACK OF MICROSATELLITE INSTABILITY IN HUMAN PROSTATE-CANCER". International Journal of Oncology 6.6 (1995): 1173-1176.
Chicago
CHRISTIANS, F., CONNOLLY, D., TSUCHIYA, K., TRUE, L., LOEB, L."LACK OF MICROSATELLITE INSTABILITY IN HUMAN PROSTATE-CANCER". International Journal of Oncology 6, no. 6 (1995): 1173-1176. https://doi.org/10.3892/ijo.6.6.1173