EXPRESSION OF A TUMOR-SUPPRESSOR GENE AND OF VARIOUS PROTOONCOGENES IN HUMAN AND MURINE ADRIAMYCIN-RESISTANT AND SENSITIVE CELL-LINES
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- Published online on: June 1, 1995 https://doi.org/10.3892/ijo.6.6.1255
- Pages: 1255-1260
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Abstract
Besides established mechanisms involved in cellular drug resistance including P-glycoprotein overexpression, topoisomerase alterations and xenobiotic detoxification, the hypothesis that proto-oncogene activation might also play a role in cell resistance has been postulated. This hypothesis has been tested by comparing the expression of various proto-oncogenes involved in signal transduction pathways (c-H-ras, c-g-ras, c-mil, c-myc, c-myb, c-fos), as well as the mdr gene and a tumor suppressor gene (p53) in different adriamycin-resistant (acquired or de novo) or sensitive cell lines, The implication of these variations in the process of chemoresistance is discussed.
