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POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION

  • Authors:
    • A DE
    • N BOYADJIEVA
    • MG PASTORCIC
    • DK SARKAR

  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/ijo.7.3.643
  • Pages: 643-648
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
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Abstract

The effect of alcohol on estrogen-regulated lactotropic cell proliferation was examined in Fisher 344 rats. Alcohol was administered for 2 weeks using liquid diet containing 8.7% ethanol (v/v) and 37% ethanol-derived calories. The control group was pair-fed with an isocaloric diet minus the ethanol or adlib-fed with normal diet. Ethanol-treated rats showed mean blood ethanol concentrations between 60-90 mg/dl. Alcohol treatment did not effect the body growth rate, but increased the DNA synthesis in lactotropes and reduced the levels of lactotropic growth inhibitory transforming growth factor-beta 1 (TGF-beta 1) protein and mRNA in the pituitary. These results suggest that alcohol promotes estrogen-induced lactotropic proliferation, possibly by down regulating the inhibitory TGF-beta 1 control of lactotropic function.

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September 1995
Volume 7 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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  • Impact Factor: 4.5
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  • CiteScore: 9.6
  • CiteScore Rank: Q1: #66/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.88
  • SCImago Journal Rank (SJR): 1.099
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Spandidos Publications style
DE A, BOYADJIEVA N, PASTORCIC M and SARKAR D: POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION. Int J Oncol 7: 643-648, 1995.
APA
DE, A., BOYADJIEVA, N., PASTORCIC, M., & SARKAR, D. (1995). POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION. International Journal of Oncology, 7, 643-648. https://doi.org/10.3892/ijo.7.3.643
MLA
DE, A., BOYADJIEVA, N., PASTORCIC, M., SARKAR, D."POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION". International Journal of Oncology 7.3 (1995): 643-648.
Chicago
DE, A., BOYADJIEVA, N., PASTORCIC, M., SARKAR, D."POTENTIATION OF THE MITOGENIC EFFECT OF ESTROGEN ON THE PITUITARY-GLAND BY ALCOHOL-CONSUMPTION". International Journal of Oncology 7, no. 3 (1995): 643-648. https://doi.org/10.3892/ijo.7.3.643