Pleiotropic functions of ETS-1 (Review)

Bhat,N; Fischinger,P; Seth,A; Watson,D; Papas,T

doi:10.3892/ijo.8.5.841

Pleiotropic functions of ETS-1 (Review)

Authors:
- N Bhat
- P Fischinger
- A Seth
- D Watson
- T Papas
View Affiliations

Affiliations: WOMENS COLL HOSP,TORONTO,ON,CANADA. UNIV TORONTO,MRC GRP,TORONTO,ON M5S 1A1,CANADA. MED UNIV S CAROLINA,HOLLINGS CANC CTR,CTR MOL & STRUCT BIOL,CHARLESTON,SC 29425.
Published online on: May 1, 1996 https://doi.org/10.3892/ijo.8.5.841
Pages: 841-846

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Abstract

ETS-1 is a cellular homologue of the viral ets oncogene of the E26 virus and functions as a sequence specific transcription factor. It plays an important role in cell proliferation, differentiation, lymphoid cell development, transformation, angiogenesis and apoptosis. ETS-1 may control the expression of critical genes involved in these processes by binding to ets binding sites present in their transcriptional regulatory regions. Recent progress in understanding the multiple functions of ETS-1 is summarized in this review.