alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies

  • Authors:
    • M Caraglia
    • A Leardi
    • B Ricciardi
    • M De Laurentiis
    • M Graziano
    • E Matano
    • S De Placido
    • A Bianco
    • P Tagliaferri
  • View Affiliations

  • Published online on: May 1, 1996     https://doi.org/10.3892/ijo.8.5.847
  • Pages: 847-850
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Abstract

We have demonstrated that interferon-alpha 2 recombinant (IFN alpha) inhibits the growth and modulates the expression of the receptor for transferrin (TRF-R) in human epidermoid carcinoma KB cells. Receptor upregulation results in the reconstitution of intracellular iron levels in the IFN alpha-treated cells. Several anti-TRF-R murine monoclonal antibodies (MAbs) have been generated which induce tumor cell growth inhibition through blockade of receptor function. We have evaluated by MTT assay the effect of anti-TRF-R 42/6, E2.3, A27.15 and D65.30 MAbs given in combination with IFN alpha on the growth of human epidermoid carcinoma KB cells. We found that IFN alpha and A27.15 MAb induced a synergistic antiproliferative effect on these cells. These results suggest that IFN alpha may potentiate the antitumor efficacy of TRF-R-targeted therapy.

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May 1996
Volume 8 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Caraglia M, Leardi A, Ricciardi B, De Laurentiis M, Graziano M, Matano E, De Placido S, Bianco A and Tagliaferri P: alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies. Int J Oncol 8: 847-850, 1996.
APA
Caraglia, M., Leardi, A., Ricciardi, B., De Laurentiis, M., Graziano, M., Matano, E. ... Tagliaferri, P. (1996). alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies. International Journal of Oncology, 8, 847-850. https://doi.org/10.3892/ijo.8.5.847
MLA
Caraglia, M., Leardi, A., Ricciardi, B., De Laurentiis, M., Graziano, M., Matano, E., De Placido, S., Bianco, A., Tagliaferri, P."alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies". International Journal of Oncology 8.5 (1996): 847-850.
Chicago
Caraglia, M., Leardi, A., Ricciardi, B., De Laurentiis, M., Graziano, M., Matano, E., De Placido, S., Bianco, A., Tagliaferri, P."alpha-Interferon potentiates the growth inhibitory effects of anti-transferrin receptor monoclonal antibodies". International Journal of Oncology 8, no. 5 (1996): 847-850. https://doi.org/10.3892/ijo.8.5.847