Differential expression between PAX-6 and EN proteins in medulloblastoma
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- Published online on: May 1, 1996 https://doi.org/10.3892/ijo.8.5.901
- Pages: 901-910
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Abstract
A collection of 28 medulloblastomas was analyzed for expression of the developmental control genes PAX-6 and EN by immunohistochemical staining. Sixteen medulloblastomas expressed both EN and PAX-6 but, when differentiation could be assessed in the positive areas, PAX-6 is expressed in the less differentiated cells. Since Drosophila en encodes a negative regulator, we overexpressed the chicken en-1 in retinal pigmented epithelium cells. This resulted in Pax-6 down regulation. These results suggest a regulatory loop between PAX-6 and EN, two molecular markers of medulloblastoma.