Open Access

Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)

  • Authors:
    • Leonie Smeenk
    • Marion Lohrum
  • View Affiliations

  • Published online on: November 1, 2010     https://doi.org/10.3892/ijo_00000757
  • Pages: 1061-1070
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Abstract

The p53 protein is a tumor suppressor that plays a crucial role in cellular growth regulation inducing a plethora of response pathways. p53 post-translational modifications, p53-binding proteins, co-factors and the p53-family members p63 and p73 have all been described to contribute to p53 target gene regulation and hence cellular outcome. However, the molecular mechanisms that discriminate between the different p53-responses towards stress treatments have remained largely elusive. This review focuses on the topic of the molecular mechanisms behind target gene selectivity of the transcription factor p53 and provides insight into the latest era of p53 research.

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November 2010
Volume 37 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Smeenk L and Lohrum M: Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review). Int J Oncol 37: 1061-1070, 2010.
APA
Smeenk, L., & Lohrum, M. (2010). Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review). International Journal of Oncology, 37, 1061-1070. https://doi.org/10.3892/ijo_00000757
MLA
Smeenk, L., Lohrum, M."Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)". International Journal of Oncology 37.5 (2010): 1061-1070.
Chicago
Smeenk, L., Lohrum, M."Behind the scenes: Unravelling the molecular mechanisms of p53 target gene selectivity (Review)". International Journal of Oncology 37, no. 5 (2010): 1061-1070. https://doi.org/10.3892/ijo_00000757