Diagnostic challenges in minimal deviation adenocarcinoma of the uterine cervix: A report of two cases and review of the literature

Guo,Feifei; Hu,Yali; Xu,Xiaofeng; Li,Rong; Ru,Tong; Wang,Jingmei; Zhou,Huaijun

doi:10.3892/mco.2013.144

Diagnostic challenges in minimal deviation adenocarcinoma of the uterine cervix: A report of two cases and review of the literature

Authors:
- Feifei Guo
- Yali Hu
- Xiaofeng Xu
- Rong Li
- Tong Ru
- Jingmei Wang
- Huaijun Zhou
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Affiliations: Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China, Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China
Published online on: July 8, 2013 https://doi.org/10.3892/mco.2013.144
Pages: 833-838

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Abstract

Minimal deviation adenocarcinoma (MDA) of the uterine cervix, otherwise known as adenoma malignum, is a rare variant of cervical adenocarcinoma, which represents a diagnostic challenge in the field of gynecologic oncology, due to its benign‑resembling histological characteristics. To achieve a better understanding of this disease, we present two cases of MDA: one case presented with profuse watery discharge and cervical enlargement, accompanied by retention cysts and hardening; the other presented with a history of myoma cervicis uteri. Both patients underwent total abdominal hysterectomy, bilateral salpingo‑oophorectomy and pelvic lymphadenectomy and our follow‑up indicated that the patients were still free of any disease. Subsequently, a literature review was performed and the results demonstrated that early diagnosis, clinical stage and surgical protocols are the main factors affecting the prognosis of MDA. close follow‑up of the cases may provide more information regarding this disease and the efficacy of the available therapeutic methods.

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