Brain metastasis as an isolated late recurrence in small‑cell lung cancer

Kurishima,Koichi; Homma,Shinsuke; Kagohashi,Katsunori; Miyazaki,Kunihiko; Kawaguchi,Mio; Satoh,Hiroaki; Hizawa,Nobuyuki

doi:10.3892/mco.2013.236

March-April 2014 Volume 2 Issue 2

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March-April 2014 Volume 2 Issue 2

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Article

Brain metastasis as an isolated late recurrence in small‑cell lung cancer

Authors:
- Koichi Kurishima
- Shinsuke Homma
- Katsunori Kagohashi
- Kunihiko Miyazaki
- Mio Kawaguchi
- Hiroaki Satoh
- Nobuyuki Hizawa
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Affiliations: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 10-0015, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 10-0015, Japan
Pages: 305-307
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Published online on: December 31, 2013

https://doi.org/10.3892/mco.2013.236
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Abstract

The brain is one of the most common sites of metastasis of small‑cell lung cancer (SCLC). In this study, we reported 6 cases with isolated brain relapse of SCLC ≥1 year after the completion of the initial treatment for SCLC. Of the 6 patients, 2 had a solitary brain metastasis and 4 had ≥2 brain metastatic sites. The metastases were identified during a regular check-up computed tomography (CT) scan and were successfully treated. The median interval from the initial diagnosis to the development of brain metastasis was 16 months (range, 13-30 months). All patients received whole‑brain irradiation and achieved a complete response. Only one patient developed disturbances of the higher cerebral function. The median interval from whole‑brain irradiation to death or last follow-up was 33 months (range, 8-90 months). To the best of our knowledge, these are the first reported cases with isolated brain relapse of SCLC. Although a rare finding, clinicians should be alert on the possibility of such recurrence, particularly in patients who refused prophylactic cranial irradiation.

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Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Brain metastasis as an isolated late recurrence in small‑cell lung cancer

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