Brain metastasis as an isolated late recurrence in small‑cell lung cancer

Kurishima,Koichi; Homma,Shinsuke; Kagohashi,Katsunori; Miyazaki,Kunihiko; Kawaguchi,Mio; Satoh,Hiroaki; Hizawa,Nobuyuki

doi:10.3892/mco.2013.236

Brain metastasis as an isolated late recurrence in small‑cell lung cancer

Authors:
- Koichi Kurishima
- Shinsuke Homma
- Katsunori Kagohashi
- Kunihiko Miyazaki
- Mio Kawaguchi
- Hiroaki Satoh
- Nobuyuki Hizawa
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Affiliations: Division of Respiratory Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 10-0015, Japan, Division of Respiratory Medicine, Mito Medical Center, University of Tsukuba, Mito, Ibaraki 10-0015, Japan
Published online on: December 31, 2013 https://doi.org/10.3892/mco.2013.236
Pages: 305-307

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Abstract

The brain is one of the most common sites of metastasis of small‑cell lung cancer (SCLC). In this study, we reported 6 cases with isolated brain relapse of SCLC ≥1 year after the completion of the initial treatment for SCLC. Of the 6 patients, 2 had a solitary brain metastasis and 4 had ≥2 brain metastatic sites. The metastases were identified during a regular check-up computed tomography (CT) scan and were successfully treated. The median interval from the initial diagnosis to the development of brain metastasis was 16 months (range, 13-30 months). All patients received whole‑brain irradiation and achieved a complete response. Only one patient developed disturbances of the higher cerebral function. The median interval from whole‑brain irradiation to death or last follow-up was 33 months (range, 8-90 months). To the best of our knowledge, these are the first reported cases with isolated brain relapse of SCLC. Although a rare finding, clinicians should be alert on the possibility of such recurrence, particularly in patients who refused prophylactic cranial irradiation.

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