search button

Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori‑negative gastric cancer among various populations in China

  • Authors:
    • Jiuda Zhao
    • Paili Geng
    • Zhanquan Li
    • Sen Cui
    • Junhui Zhao
    • Lijuan Wang
    • Jinzhang Li
    • Faxiang Ji
    • Guoyuan Li
    • Guoshuang Shen
    • Mingzhe Lin
    • Cunfang Shen

  • View Affiliations

  • Published online on: January 14, 2013     https://doi.org/10.3892/mco.2013.70
  • Pages: 493-498
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Gastric cancer is a lethal disease with a high morality rate. Studies have suggested that prostate stem cell antigen (PSCA) rs2294008 polymorphism is associated with gastric cancer (GC). In this case‑control study, we investigated rs2294008 polymorphism in the Tibet, Hui and Han nationalities in the Qinghai area of China. Genomic DNA was extracted from the peripheral blood of 286, 315 and 350 healthy volunteers and from 219, 233 and 265 Helicobacter pylori‑negative non‑cardia GC patients from the Tibet, Hui and Han populations, respectively. The rs2294008 polymorphism was analyzed by denaturing high‑performance liquid chromatography. rs2294008 CT and TT genotypes were associated with GC both in the Tibet and Han populations (adjusted OR=1.51, 1.47, 2.01, 1.85; 95% CI, 1.04‑2.19, 1.05‑2.06, 1.04‑3.88, 1.03‑3.34; P=0.030, 0.025, 0.039, 0.040, respectively). rs2294008 TT genotype was associated with GC in the Hui population (adjusted OR=2.14; 95% CI, 1.29‑3.55; P=0.003). Furthermore, when stratified by histopathology, the rs2294008 CT and TT genotypes were associated with diffuse GC in the Tibet and Han nationalities (adjusted OR=1.93, 1.73, 2.69, 2.86; 95% CI, 1.09‑3.44, 1.01‑2.95, 1.06‑6.84, 1.27‑6.46; P=0.025, 0.045, 0.038, 0.011, respectively). However, the rs2294008 TT genotype was associated with both intestinal and diffuse types of GC (adjusted OR=2.10, 2.21; 95% CI, 1.17‑3.75, 1.12‑4.38; P=0.012, 0.023, respectively) and the rs2294008 CT genotype was only associated with intestinal-type GC in the Hui nationalitiy group (adjusted OR=1.60; 95% CI, 1.04‑2.47; P=0.034). The results therefore showed that rs2294008 may differentially contribute to GC among different nationalities in one area and its role is independent from Helicobacter pylori‑infection.
View References

Related Articles

Journal Cover

May-June 2013
Volume 1 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 1.4
  • Ranked
    (total number of cites)
  • CiteScore: 2.8
  • CiteScore Rank: Q3: #250/404 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.55
  • SCImago Journal Rank (SJR): 0.446
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Zhao J, Geng P, Li Z, Cui S, Zhao J, Wang L, Li J, Ji F, Li G, Shen G, Shen G, et al: Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori‑negative gastric cancer among various populations in China. Mol Clin Oncol 1: 493-498, 2013.
APA
Zhao, J., Geng, P., Li, Z., Cui, S., Zhao, J., Wang, L. ... Shen, C. (2013). Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori‑negative gastric cancer among various populations in China. Molecular and Clinical Oncology, 1, 493-498. https://doi.org/10.3892/mco.2013.70
MLA
Zhao, J., Geng, P., Li, Z., Cui, S., Zhao, J., Wang, L., Li, J., Ji, F., Li, G., Shen, G., Lin, M., Shen, C."Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori‑negative gastric cancer among various populations in China". Molecular and Clinical Oncology 1.3 (2013): 493-498.
Chicago
Zhao, J., Geng, P., Li, Z., Cui, S., Zhao, J., Wang, L., Li, J., Ji, F., Li, G., Shen, G., Lin, M., Shen, C."Prostate stem cell antigen rs2294008 polymorphism differentially contributes to Helicobacter pylori‑negative gastric cancer among various populations in China". Molecular and Clinical Oncology 1, no. 3 (2013): 493-498. https://doi.org/10.3892/mco.2013.70