Interstitial pneumonia associated with neoadjuvant chemotherapy in breast cancer
- Authors:
- Hidemi Kawajiri
- Tsutomu Takashima
- Naoyoshi Onoda
- Shinichiro Kashiwagi
- Tetsurou Ishikawa
- Kosei Hirakawa
-
View Affiliations
Affiliations: Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka 545-8585, Japan
- Published online on: March 5, 2013 https://doi.org/10.3892/mco.2013.87
-
Pages:
433-436
Metrics:
Total
Views: 0 (Spandidos Publications: | PMC Statistics:
)
Metrics:
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics:
)
This article is mentioned in:
Abstract
Interstitial pneumonia (IP) is a critical adverse event that may occur during anticancer chemotherapy. Physicians should be aware of the possibility of IP, particularly when dealing with patients on neoadjuvant chemotherapy (NAC) since delays in diagnosis and treatment interfere with the scheduled operation. In our institution, fluorouracil, epirubicin and cyclophosphamide (FEC) followed by weekly paclitaxel is the standard NAC regimen for operable breast cancer cases. In the present study, 95 patients with breast cancer were treated with this regimen, 5 of whom (5.3%) developed IP during NAC. All 5 cases were diagnosed when anticancer therapy was withdrawn and steroid pulse therapy was initiated. Consequently, the standard operation was immediately performed. In conclusion, physicians should be aware that IP may occur at any point during NAC and that it should be immediately diagnosed and treated to avoid delay of the therapeutic plan.
View References
|
1.
|
Delaunois LM: Mechanisms in pulmonary
toxicology. Clin Chest Med. 25:1–14. 2004. View Article : Google Scholar
|
|
2.
|
Nagata S, Ueda N, Yoshida Y, et al: Severe
interstitial pneumonitis associated with the administration of
taxanes. J Infect Chemother. 16:340–304. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
3.
|
Wolmark N, Wang J, Mamounas E, et al:
Preoperative chemotherapy in patients with operable breast cancer:
nine-year results from National Surgical Adjuvant Breast and Bowel
Project B-18. J Natl Cancer Inst Monogr. 30:96–102. 2001.
|
|
4.
|
van der Hage JA, van de Velde CJ, Julien
JP, et al: Preoperative chemotherapy in primary operable breast
cancer: results from the European Organization for Research and
Treatment of Cancer trial 10902. J Clin Oncol. 19:4224–4237.
2001.
|
|
5.
|
Bear HD, Anderson S, Brown A, et al: The
effect on tumor response of adding sequential preoperative
docetaxel to preoperative doxorubicin and cyclophosphamide:
preliminary results from National Surgical Adjuvant Breast and
Bowel Project Protocol B-27. J Clin Oncol. 21:4165–4174. 2003.
View Article : Google Scholar
|
|
6.
|
Bear HD, Anderson S, Smith RE, et al:
Sequential preoperative or postoperative docetaxel added to
preoperative doxorubicin plus cyclophosphamide for operable breast
cancer: National Surgical Adjuvant Breast and Bowel Project
Protocol B-27. J Clin Oncol. 24:2019–2027. 2006. View Article : Google Scholar
|
|
7.
|
Segura A, Yuste A, Cercos A, et al:
Pulmonary fibrosis induced by cyclophosphamide. Ann Pharmacother.
35:894–897. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
8.
|
Khan A, McNally D, Tutschka PJ and
Bilgrami S: Paclitaxel-induced acute bilateral pneumonitis. Ann
Pharmacother. 31:1471–1474. 1997.PubMed/NCBI
|
|
9.
|
Ellis SJ, Cleverley JR and Müller NL:
Drug-induced lung disease: high-resolution CT findings. AJR Am J
Roentgenol. 175:1019–1024. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
10.
|
Camus PH, Foucher P, Bonniaud PH and Ask
K: Drug-induced infiltrative lung disease. Eur Respir J Suppl.
32:S93–S100. 2001.
|
|
11.
|
Elliot TL, Lynch DA, Newell JD Jr, et al:
High-resolution computed tomography features of nonspecific
interstitial pneumonia and usual interstitial pneumonia. J Comput
Assist Tomogr. 29:339–345. 2005. View Article : Google Scholar : PubMed/NCBI
|
|
12.
|
Wang GS, Yang KY and Perng RP:
Life-threatening hypersensitivity pneumonitis induced by docetaxel
(taxotere). Br J Cancer. 85:1247–1250. 2001. View Article : Google Scholar : PubMed/NCBI
|
