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Article

Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer

  • Authors:
    • Takeshi Kajiwara
    • Yoichi Hiasa
    • Tomohiro Nishina
    • Toshihiko Matsumoto
    • Shinichiro Hori
    • Seijin Nadano
    • Haruo Iguchi
    • Satoru Takeji
    • Eiji Tsubouchi
    • Yoshio Ikeda
    • Morikazu Onji
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime 791‑0280, Japan, Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Toon, Ehime 791‑0295, Japan
  • Pages: 313-321
    |
    Published online on: January 7, 2014
       https://doi.org/10.3892/mco.2014.238
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Abstract

Positron emission tomography/computed tomography (PET/CT) with 18F‑fluoro‑2‑deoxyglucose (FDG‑PET/CT) has become established in cancer imaging, and derived maximum standardized uptake values (SUVmax) add functional information regarding cancer, including esophageal squamous cell carcinoma (ESCC). The aim of the present study was to determine the clinical significance and association of tumor progression using SUVmax derived from PET/CT images in patients with ESCC. In total, 101 patients with ESCC were assessed using FDG‑PET/CT and the SUVmax was then compared with the clinical backgrounds and prognoses of the patients. Endoscopic ESCC biopsy specimens were obtained in order to analyze mRNA expression relative to tumor progression. The results showed that values for SUVmax were significantly higher in patients with tumor progression factors, particularly those with lymph node metastasis. Analysis of receiver operating characteristics curves revealed an optimum SUVmax cut‑off value of 10.26 for node‑positive disease. Patients with SUVmax ≥10.26 had gene alterations with epithelial‑mesenchymal transition (EMT) and significantly worse overall survival (P=0.0012). A higher SUVmax in patients with ESCC was associated with lymph node metastasis and a poorer prognosis. Thus, the SUVmax may reflect the potential of EMT in patients with ESCC.
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Copy and paste a formatted citation
Spandidos Publications style
Kajiwara T, Hiasa Y, Nishina T, Matsumoto T, Hori S, Nadano S, Iguchi H, Takeji S, Tsubouchi E, Ikeda Y, Ikeda Y, et al: Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer. Mol Clin Oncol 2: 313-321, 2014.
APA
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S. ... Onji, M. (2014). Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer. Molecular and Clinical Oncology, 2, 313-321. https://doi.org/10.3892/mco.2014.238
MLA
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S., Iguchi, H., Takeji, S., Tsubouchi, E., Ikeda, Y., Onji, M."Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer". Molecular and Clinical Oncology 2.2 (2014): 313-321.
Chicago
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S., Iguchi, H., Takeji, S., Tsubouchi, E., Ikeda, Y., Onji, M."Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer". Molecular and Clinical Oncology 2, no. 2 (2014): 313-321. https://doi.org/10.3892/mco.2014.238
Copy and paste a formatted citation
x
Spandidos Publications style
Kajiwara T, Hiasa Y, Nishina T, Matsumoto T, Hori S, Nadano S, Iguchi H, Takeji S, Tsubouchi E, Ikeda Y, Ikeda Y, et al: Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer. Mol Clin Oncol 2: 313-321, 2014.
APA
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S. ... Onji, M. (2014). Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer. Molecular and Clinical Oncology, 2, 313-321. https://doi.org/10.3892/mco.2014.238
MLA
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S., Iguchi, H., Takeji, S., Tsubouchi, E., Ikeda, Y., Onji, M."Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer". Molecular and Clinical Oncology 2.2 (2014): 313-321.
Chicago
Kajiwara, T., Hiasa, Y., Nishina, T., Matsumoto, T., Hori, S., Nadano, S., Iguchi, H., Takeji, S., Tsubouchi, E., Ikeda, Y., Onji, M."Maximum standardized uptake value in 18F‑fluoro‑2‑deoxyglucose positron emission tomography is associated with advanced tumor factors in esophageal cancer". Molecular and Clinical Oncology 2, no. 2 (2014): 313-321. https://doi.org/10.3892/mco.2014.238
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