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Molecular and Clinical Oncology
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Print ISSN: 2049-9450 Online ISSN: 2049-9469
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March-April 2014 Volume 2 Issue 2

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International Journal of Molecular Medicine

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

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International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

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Article

Effect of bowel obstruction on stage IV colorectal cancer

  • Authors:
    • Wei Chen
    • Xiao‑Ping Tan
    • Jun‑Wen Ye
    • Qin Liu
    • Qingli Zeng
    • Lei Wang
    • Jian‑Ping Wang
  • View Affiliations / Copyright

    Affiliations: Department of Colorectal Surgery, The Sixth Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510655, P.R. China, Emergency Department, The Fourth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510655, P.R. China, Chongqing Hospital of Traditional Chinese Medicine, Jiangbei, Chongqing 400021, P.R. China, Department of General Surgery, Jiangxi Provincial People's Hospital, Nanchang, Jiangxi 330006, P.R. China
  • Pages: 308-312
    |
    Published online on: January 10, 2014
       https://doi.org/10.3892/mco.2014.240
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Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with a high mortality rate, particularly among patients with advanced‑stage disease complicated by bowel obstruction. The present study aimed to investigate the value of different surgical procedures and potential predictors of survival for patients with stage IV CRC, with or without bowel obstruction. Between August, 1994 and December, 2005, a total of 2,950 CRC patients were diagnosed and treated at our hospital. Among these, 381 patients had stage IV disease and were divided into two groups according to the presence (n=295) or absence (n=86) of bowel obstruction. The clinical data of all the patients with stage IV CRC were retrospectively analyzed and all the patients were followed up. Our results demonstrated statistically significant differences in gender, radical resection, histological type, ascites, tumor location, peritoneal and liver metastases between the obstruction and non‑obstruction groups. We also observed that hepatic metastases and radical resection were factors associated with prognosis according to the univariate and multivariate analyses. Furthermore, the mean̸median survival time was 49.4̸21.6 and 37.2̸17.1 months in the non‑obstruction and obstruction groups, respectively. In conclusion, obstruction was not found to be an independent indicator of survival for patients with stage IV CRC, with patients in the obstruction group exhibiting a worse overall survival compared to those in the non‑obstruction group, whereas active radical surgery significantly improved the prognosis of patients with stage IV CRC.
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1 

Parkin DM, Bray F, Ferlay J and Pisani P: Global cancer statistics, 2002. CA Cancer J Clin. 55:74–108. 2005. View Article : Google Scholar

2 

Jemal A, Siegel R, Ward E, et al: Cancer statistics, 2006. CA Cancer J Clin. 56:106–130. 2006. View Article : Google Scholar

3 

Chen HS and Sheen-Chen SM: Obstruction and perforation in colorectal adenocarcinoma: an analysis of prognosis and current trends. Surgery. 127:370–376. 2000. View Article : Google Scholar : PubMed/NCBI

4 

Lee YM, Law WL, Chu KW and Poon RT: Emergency surgery for obstructing colorectal cancers: a comparison between right-sided and left-sided lesions. J Am Coll Surg. 192:719–725. 2001. View Article : Google Scholar : PubMed/NCBI

5 

Phillips RK, Hittinger R, Fry JS and Fielding LP: Malignant large bowel obstruction. Br J Surg. 72:296–302. 1985. View Article : Google Scholar : PubMed/NCBI

6 

Ohman U: Prognosis in patients with obstructing colorectal carcinoma. Am J Surg. 143:742–747. 1982. View Article : Google Scholar : PubMed/NCBI

7 

McArdle CS and Hole DJ: Emergency presentation of colorectal cancer is associated with poor 5-year survival. Br J Surg. 91:605–609. 2004.PubMed/NCBI

8 

Michel P, Roque I, Di Fiore F, et al: Colorectal cancer with non-resectable synchronous metastases: should the primary tumor be resected? Gastroenterol Clin Biol. 28:434–437. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Clements D, Dhruva Rao P, Ramanathan D, Adams R, Maughan TS and Davies MM: Management of the asymptomatic primary in the palliative treatment of metastatic colorectal cancer. Colorectal Dis. 11:845–848. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Scoggins CR, Meszoely IM, Blanke CD, Beauchamp RD and Leach SD: Nonoperative management of primary colorectal cancer in patients with stage IV disease. Ann Surg Oncol. 6:651–657. 1999. View Article : Google Scholar : PubMed/NCBI

11 

Kaufman MS, Radhakrishnan N, Roy R, et al: Influence of palliative surgical resection on overall survival in patients with advanced colorectal cancer: a retrospective single institutional study. Colorectal Dis. 10:498–502. 2008. View Article : Google Scholar

12 

Stelzner S, Hellmich G, Koch R and Ludwig K: Factors predicting survival in stage IV colorectal carcinoma patients after palliative treatment: a multivariate analysis. J Surg Oncol. 89:211–217. 2005. View Article : Google Scholar

13 

Ruo L, Gougoutas C, Paty PB, Guillem JG, Cohen AM and Wong WD: Elective bowel resection for incurable stage IV colorectal cancer: prognostic variables for asymptomatic patients. J Am Coll Surg. 196:722–728. 2003. View Article : Google Scholar : PubMed/NCBI

14 

Rosen SA, Buell JF, Yoshida A, et al: Initial presentation with stage IV colorectal cancer: how aggressive should we be? Arch Surg. 135:530–535. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Kornprat P, Pollheimer MJ, Lindtner RA, Schlemmer A, Rehak P and Langner C: Value of tumor size as a prognostic variable in colorectal cancer: a critical reappraisal. Am J Clin Oncol. 34:43–49. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Abdalla EK: Resection of colorectal liver metastases. J Gastrointest Surg. 15:416–419. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Wong SK, Kneebone A, Morgan M, Henderson CJ, Morgan A and Jalaludin B: Surgical management of colorectal cancer in south-western Sydney 1997–2001: a prospective series of 1293 unselected cases from six public hospitals. ANZ J Surg. 75:776–782. 2005.PubMed/NCBI

18 

Liang H, Wang XN, Wang BG, et al: Prognostic factors of young patients with colon cancer after surgery. World J Gastroenterol. 12:1458–1462. 2006.PubMed/NCBI

19 

Hotokezaka M, Jimi S, Hidaka H, et al: Factors influencing outcome after surgery for stage IV colorectal cancer. Surg Today. 38:784–789. 2008. View Article : Google Scholar : PubMed/NCBI

20 

Yang Z, Wang L, Kang L, et al: Clinicopathologic characteristics and outcomes of patients with obstructive colorectal cancer. J Gastrointest Surg. 15:1213–1222. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Sarela AI, Guthrie JA, Seymour MT, Ride E, Guillou PJ and O’Riordain DS: Non-operative management of the primary tumour in patients with incurable stage IV colorectal cancer. Br J Surg. 88:1352–1356. 2001. View Article : Google Scholar : PubMed/NCBI

22 

Nash GM, Saltz LB, Kemeny NE, et al: Radical resection of rectal cancer primary tumor provides effective local therapy in patients with stage IV disease. Ann Surg Oncol. 9:954–960. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Jayne DG, Fook S, Loi C and Seow-Choen F: Peritoneal carcinomatosis from colorectal cancer. Br J Surg. 89:1545–1550. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Higashi H, Shida H, Ban K, et al: Factors affecting successful palliative surgery for malignant bowel obstruction due to peritoneal dissemination from colorectal cancer. Jpn J Clin Oncol. 33:357–359. 2003. View Article : Google Scholar

25 

Manfredi S, Lepage C, Hatem C, Coatmeur O, Faivre J and Bouvier AM: Epidemiology and management of liver metastases from colorectal cancer. Ann Surg. 244:254–259. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chen W, Tan XP, Ye JW, Liu Q, Zeng Q, Wang L and Wang JP: Effect of bowel obstruction on stage IV colorectal cancer. Mol Clin Oncol 2: 308-312, 2014.
APA
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., & Wang, J. (2014). Effect of bowel obstruction on stage IV colorectal cancer. Molecular and Clinical Oncology, 2, 308-312. https://doi.org/10.3892/mco.2014.240
MLA
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., Wang, J."Effect of bowel obstruction on stage IV colorectal cancer". Molecular and Clinical Oncology 2.2 (2014): 308-312.
Chicago
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., Wang, J."Effect of bowel obstruction on stage IV colorectal cancer". Molecular and Clinical Oncology 2, no. 2 (2014): 308-312. https://doi.org/10.3892/mco.2014.240
Copy and paste a formatted citation
x
Spandidos Publications style
Chen W, Tan XP, Ye JW, Liu Q, Zeng Q, Wang L and Wang JP: Effect of bowel obstruction on stage IV colorectal cancer. Mol Clin Oncol 2: 308-312, 2014.
APA
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., & Wang, J. (2014). Effect of bowel obstruction on stage IV colorectal cancer. Molecular and Clinical Oncology, 2, 308-312. https://doi.org/10.3892/mco.2014.240
MLA
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., Wang, J."Effect of bowel obstruction on stage IV colorectal cancer". Molecular and Clinical Oncology 2.2 (2014): 308-312.
Chicago
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., Wang, J."Effect of bowel obstruction on stage IV colorectal cancer". Molecular and Clinical Oncology 2, no. 2 (2014): 308-312. https://doi.org/10.3892/mco.2014.240
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