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Effect of bowel obstruction on stage IV colorectal cancer

  • Authors:
    • Wei Chen
    • Xiao‑Ping Tan
    • Jun‑Wen Ye
    • Qin Liu
    • Qingli Zeng
    • Lei Wang
    • Jian‑Ping Wang

  • View Affiliations

  • Published online on: January 10, 2014     https://doi.org/10.3892/mco.2014.240
  • Pages: 308-312
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Abstract

Colorectal cancer (CRC) is the third most commonly diagnosed cancer worldwide, with a high mortality rate, particularly among patients with advanced‑stage disease complicated by bowel obstruction. The present study aimed to investigate the value of different surgical procedures and potential predictors of survival for patients with stage IV CRC, with or without bowel obstruction. Between August, 1994 and December, 2005, a total of 2,950 CRC patients were diagnosed and treated at our hospital. Among these, 381 patients had stage IV disease and were divided into two groups according to the presence (n=295) or absence (n=86) of bowel obstruction. The clinical data of all the patients with stage IV CRC were retrospectively analyzed and all the patients were followed up. Our results demonstrated statistically significant differences in gender, radical resection, histological type, ascites, tumor location, peritoneal and liver metastases between the obstruction and non‑obstruction groups. We also observed that hepatic metastases and radical resection were factors associated with prognosis according to the univariate and multivariate analyses. Furthermore, the mean̸median survival time was 49.4̸21.6 and 37.2̸17.1 months in the non‑obstruction and obstruction groups, respectively. In conclusion, obstruction was not found to be an independent indicator of survival for patients with stage IV CRC, with patients in the obstruction group exhibiting a worse overall survival compared to those in the non‑obstruction group, whereas active radical surgery significantly improved the prognosis of patients with stage IV CRC.
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March-April 2014
Volume 2 Issue 2

Print ISSN: 2049-9450
Online ISSN:2049-9469

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  • Impact Factor: 1.2
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  • CiteScore: 2.6
  • CiteScore Rank: Q3: #242/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.693
  • SCImago Journal Rank (SJR): 0.393
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Spandidos Publications style
Chen W, Tan XP, Ye JW, Liu Q, Zeng Q, Wang L and Wang JP: Effect of bowel obstruction on stage IV colorectal cancer. Mol Clin Oncol 2: 308-312, 2014
APA
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., & Wang, J. (2014). Effect of bowel obstruction on stage IV colorectal cancer. Molecular and Clinical Oncology, 2, 308-312. https://doi.org/10.3892/mco.2014.240
MLA
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., Wang, J."Effect of bowel obstruction on stage IV colorectal cancer". Molecular and Clinical Oncology 2.2 (2014): 308-312.
Chicago
Chen, W., Tan, X., Ye, J., Liu, Q., Zeng, Q., Wang, L., Wang, J."Effect of bowel obstruction on stage IV colorectal cancer". Molecular and Clinical Oncology 2, no. 2 (2014): 308-312. https://doi.org/10.3892/mco.2014.240