GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma

  • Authors:
    • Wey‑Ran Lin
    • Chao‑Wei Hsu
    • Yi‑Cheng Chen
    • Ming‑Ling Chang
    • Kung‑Hao Liang
    • Ya‑Hui Huang
    • Chau‑Ting Yeh
  • View Affiliations

  • Published online on: May 15, 2014     https://doi.org/10.3892/mco.2014.294
  • Pages: 630-640
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Abstract

In addition to targeted agents, chemotherapy is currently considered to be a treatment option for patients with advanced hepatocellular carcinoma (HCC); however, it is associated with severe side effects that may limit its clinical use. UDP‑N‑acetyl‑α‑D‑galactosamine:polypeptide N‑acetyl‑galactosaminyltransferase 14 (GALNT14) genotype was previously identified as a prognostic marker for HCC patients receiving 5‑fluorouracil, mitoxantrone and cisplatin (FMP) combination chemotherapy. The present study aimed to assess clinical parameters and on‑treatment side effects as effective predictors for favorable prognosis. A total of 118 patients with HCC receiving split‑dose FMP were retrospectively enrolled. The clinical parameters, side effects and GALNT14 genotype were analyzed. The independent predictors for time‑to‑progression (TTP) and overall survival (OS) were assessed using Cox proportional hazards models. Following categorization, the Kaplan‑Meier method was used to compare survival outcomes. Pretreatment α‑fetoprotein (AFP) ≤2,800 ng/ml (median level), GALNT14 ‘TT’ genotype, on‑treatment leukopenia and absence of vomiting were identified as independent predictors of a favorable TTP (P=0.001, 0.035, 0.008 and 0.009, respectively) and OS (P=0.028, 0.006, 0.027 and 0.013, respectively). A total of 59 patients with AFP ≤2,800 ng̸ml exhibited longer median TTP and OS (3.11 vs. 1.75 months, P<0.001; and 8.14 vs. 3.79 months, P<0.001, respectively). A total of 30 patients with the GALNT14 ‘TT’ genotype exhibited longer median TTP and OS (3.11 vs. 2.11 months, P=0.014; and 5.75 vs. 3.93 months, P=0.001, respectively). Finally, 9 patients (9/118; 7.6%) with all four favorable factors exhibited the longest median TTP and OS (10.64 vs. 2.07 months, P=0.002; and 25.50 vs. 4.50 months, P<0.001, respectively). In conclusion, the AFP level and the GALNT genotype may be considered as pre‑therapeutic predictors of a favorable response. When combined with on‑treatment leukopenia and absence of vomiting, a subgroup of patients with excellent outcome may be identified.
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July-August 2014
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Spandidos Publications style
Lin WR, Hsu CW, Chen YC, Chang ML, Liang KH, Huang YH and Yeh CT: GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma. Mol Clin Oncol 2: 630-640, 2014
APA
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., & Yeh, C. (2014). GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma. Molecular and Clinical Oncology, 2, 630-640. https://doi.org/10.3892/mco.2014.294
MLA
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., Yeh, C."GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma". Molecular and Clinical Oncology 2.4 (2014): 630-640.
Chicago
Lin, W., Hsu, C., Chen, Y., Chang, M., Liang, K., Huang, Y., Yeh, C."GALNT14 genotype, α‑fetoprotein and therapeutic side effects predict post‑chemotherapy survival in patients with advanced hepatocellular carcinoma". Molecular and Clinical Oncology 2, no. 4 (2014): 630-640. https://doi.org/10.3892/mco.2014.294