Alcohol consumption and risk of myelodysplastic syndromes: A meta‑analysis of epidemiological studies

Jin,Jie; Yu,Mengxia; Hu,Chao; Ye,Li; Xie,Lili; Chen,Feifei; Zhuang,Zhengping; Tong,Hongyan

doi:10.3892/mco.2014.376

Alcohol consumption and risk of myelodysplastic syndromes: A meta‑analysis of epidemiological studies

Authors:
- Jie Jin
- Mengxia Yu
- Chao Hu
- Li Ye
- Lili Xie
- Feifei Chen
- Zhengping Zhuang
- Hongyan Tong
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Affiliations: Department of Hematology, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Published online on: August 7, 2014 https://doi.org/10.3892/mco.2014.376
Pages: 1115-1120

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Abstract

Previous studies on the association between alcohol intake and the risk of myelodysplastic syndromes (MDS) have been inconclusive. We conducted a meta‑analysis to evaluate alcohol intake as a risk factor for MDS. We performed a systematic literature search of articles published before March, 2014 using Web of Science, PubMed and the Cochrane Library. Two evaluators independently selected and reviewed studies based on predetermined selection criteria. The fixed‑ or random‑effects models were used to summarize the estimates of odds ratios (ORs) with 95% confidence intervals (CIs). A total of 9 studies (8 case‑control and 1 cohort) met the inclusion criteria of this meta‑analysis. No significant association was observed between alcohol consumption and MDS when comparing drinkers to non‑drinkers (OR=1.16, 95% CI: 0.88‑1.53) or between subgroups stratified by alcohol history, gender, ethnicity, study design, source of patients or MDS subtypes. However, the data indicated a stronger association of alcohol with MDS in individuals who consumed ≥10 g/day (OR=1.55, 95% CI: 1.08‑2.21) vs. those who consumed <10 g/day (OR=1.09, 95% CI: 0.78‑1.53). This meta‑analysis suggests that alcohol intake may increase the risk of MDS in a dose‑dependent manner. However, additional well‑designed, prospective cohort studies are required to verify these findings and identify other risk factors associated with MDS.

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