Pleural lavage cytology as an independent prognostic factor in non-small‑cell lung cancer patients with stage I disease and adenocarcinoma

  • Authors:
    • Daisuke Hokka
    • Kazuya Uchino
    • Kenta Tane
    • Hiroyuki Ogawa
    • Sinya Tane
    • Yugo Tanaka
    • Shunsuke Tauchi
    • Wataru Nishio
    • Masahiro Yoshimura
    • Yoshimasa Maniwa
  • View Affiliations

  • Published online on: September 10, 2014     https://doi.org/10.3892/mco.2014.416
  • Pages: 244-248
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We previously reported that cancer cells may be detected through pleural lavage cytology (PLC). In this study, we sought to re‑examine the prognostic significance of the PLC status based on an extended dataset with an additional follow-up period. Pleural lavage following thoracotomy was cytologically examined in 1,317 consecutive patients who were diagnosed with NSCLC between 1987 and 2004 at the Thoracic Surgery Units of Kobe University Graduate School of Medicine and Hyogo Cancer Center. Among the investigated patients, 46 exhibited positive cytological findings. The prognosis of these patients was significantly worse compared to that of patients without positive PLC. Of the 844 pathological stage I patients, 18 had a positive PLC status and their prognosis was significantly worse compared to that of patients with stage I disease without positive PLC. In conclusion, positive PLC findings were associated with a poor prognosis and this finding was significant for patients with stage I disease. These results suggest the need for PLC status evaluation during staging and treatment planning in patients with NSCLC.
View Figures
View References

Related Articles

Journal Cover

January-February 2015
Volume 3 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hokka D, Uchino K, Tane K, Ogawa H, Tane S, Tanaka Y, Tauchi S, Nishio W, Yoshimura M, Maniwa Y, Maniwa Y, et al: Pleural lavage cytology as an independent prognostic factor in non-small‑cell lung cancer patients with stage I disease and adenocarcinoma. Mol Clin Oncol 3: 244-248, 2015
APA
Hokka, D., Uchino, K., Tane, K., Ogawa, H., Tane, S., Tanaka, Y. ... Maniwa, Y. (2015). Pleural lavage cytology as an independent prognostic factor in non-small‑cell lung cancer patients with stage I disease and adenocarcinoma. Molecular and Clinical Oncology, 3, 244-248. https://doi.org/10.3892/mco.2014.416
MLA
Hokka, D., Uchino, K., Tane, K., Ogawa, H., Tane, S., Tanaka, Y., Tauchi, S., Nishio, W., Yoshimura, M., Maniwa, Y."Pleural lavage cytology as an independent prognostic factor in non-small‑cell lung cancer patients with stage I disease and adenocarcinoma". Molecular and Clinical Oncology 3.1 (2015): 244-248.
Chicago
Hokka, D., Uchino, K., Tane, K., Ogawa, H., Tane, S., Tanaka, Y., Tauchi, S., Nishio, W., Yoshimura, M., Maniwa, Y."Pleural lavage cytology as an independent prognostic factor in non-small‑cell lung cancer patients with stage I disease and adenocarcinoma". Molecular and Clinical Oncology 3, no. 1 (2015): 244-248. https://doi.org/10.3892/mco.2014.416