Long non-coding RNAs and hepatocellular carcinoma (Review)

  • Authors:
    • Fu-Jun Yu
    • Jian-Jian Zheng
    • Pei-Hong Dong
    • Xiao-Ming Fan
  • View Affiliations

  • Published online on: September 25, 2014     https://doi.org/10.3892/mco.2014.429
  • Pages: 13-17
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Abstract

Recent advances in next‑generation sequencing technology in transcriptome analysis have helped identify numerous non-coding RNAs. The long non-coding RNA (lncRNA) is commonly defined as an RNA molecule with a length of 200 bp-100 kbp that lacks protein‑coding potential. LncRNAs play a critical role in the regulation of gene expression, including chromatin modification, transcription and post‑transcriptional processing. It has been confirmed that dysregulation of lncRNAs is associated with a number of human diseases, particularly tumors. In this study, we focused on the most extensively investigated lncRNAs in hepatocellular carcinoma (HCC). The biological functions and molecular mechanisms of the majority of lncRNAs have yet to be investigated. The improved knowledge on lncRNAs in HCC may help identify lncRNAs that may be used as novel prognostic markers and therapeutic targets.
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January-February 2015
Volume 3 Issue 1

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Copy and paste a formatted citation
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Spandidos Publications style
Yu F, Zheng J, Dong P and Fan X: Long non-coding RNAs and hepatocellular carcinoma (Review). Mol Clin Oncol 3: 13-17, 2015.
APA
Yu, F., Zheng, J., Dong, P., & Fan, X. (2015). Long non-coding RNAs and hepatocellular carcinoma (Review). Molecular and Clinical Oncology, 3, 13-17. https://doi.org/10.3892/mco.2014.429
MLA
Yu, F., Zheng, J., Dong, P., Fan, X."Long non-coding RNAs and hepatocellular carcinoma (Review)". Molecular and Clinical Oncology 3.1 (2015): 13-17.
Chicago
Yu, F., Zheng, J., Dong, P., Fan, X."Long non-coding RNAs and hepatocellular carcinoma (Review)". Molecular and Clinical Oncology 3, no. 1 (2015): 13-17. https://doi.org/10.3892/mco.2014.429