Prognostic significance of thymidylate synthase expression in pancreatic adenocarcinoma: A meta‑analysis

Guo,Yan‑Mei; Zhu,Min; Yu,Wei‑Wei

doi:10.3892/mco.2014.443

Prognostic significance of thymidylate synthase expression in pancreatic adenocarcinoma: A meta‑analysis

Authors:
- Yan‑Mei Guo
- Min Zhu
- Wei‑Wei Yu
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Affiliations: Department of Gastroenterology, Shanghai Tenth People's Hospital of Tongji University, Shanghai 200072, P.R. China, Department of Biostatistics, School of Public Health, Fudan University, Shanghai 200032, P.R. China, Department of Radiation Oncology, Shanghai Sixth People's Hospital Affiliated to Jiao Tong University, Shanghai 200233, P.R. China
Published online on: October 13, 2014 https://doi.org/10.3892/mco.2014.443
Pages: 121-124

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Abstract

The prognostic significance of thymidylate synthase (TS) overexpression in pancreatic adenocarcinoma has been extensively investigated; however, data on the survival of patients with pancreatic adenocarcinoma remain equivocal. We performed a meta‑analysis of previous studies to assess the effects of TS overexpression on the overall survival (OS) of patients with pancreatic adenocarcinoma, using hazard ratio (HR) with its 95% confidence interval (CI). A total of 5 studies, including 425 patients, were subjected to the final analysis. The pooled HR was 0.72 (95% CI: 0.41‑1.25; Z=1.18, P=0.238), indicating that TS expression exerted no significant survival effect on patients with pancreatic adenocarcinoma. The combined HR was 0.46 (95% CI: 0.31‑0.68; Z=3.95, P<0.001), limiting the analysis to the studies assessing R0 resection patients, which indicated that a high expression of TS was significantly correlated with better OS in patients with pancreatic adenocarcinoma who underwent R0 resection. This meta‑analysis identified TS as an independent factor predicting favourable outcome following R0 curative resection in patients with pancreatic adenocarcinoma.

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