Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma

  • Authors:
    • Melike Dinccelik‑Aslan
    • Guvem Gumus‑Akay
    • Atilla Halil Elhan
    • Ekrem Unal
    • Ajlan Tukun
  • View Affiliations

  • Published online on: January 19, 2015     https://doi.org/10.3892/mco.2015.486
  • Pages: 584-590
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Abstract

Gastric cancer is one of the most common malignancies worldwide and the second most common cause of cancer‑related mortality. Previous studies revealed several genetic alterations specific to gastric cancer. In this study, we aimed to investigate the diagnostic and prognostic significance of the expression levels of the glypican 5 and glypican 6 genes (GPC5 and GPC6, respectively) in gastric cancer. For this purpose, GPC5 and GPC6 expression was quantitatively determined by quantitative polymerase chain reaction method in normal gastric mucosa and intestinal type gastric adenocarcinoma samples from 35 patients. The expression levels of GPC5 and GPC6 were compared between normal and tumor tissues. Additionally, the association of the expression levels in tumor tissues with several clinicopathological parameters was evaluated. Although GPC5 was not expressed in any of the samples, the expression of GPC6, which was detected in both groups, was found to be significantly higher in tumor tissues compared to that in normal samples (P=0.039). However, there was no statistically significant association between GPC6 expression and any of the clinicopathological parameters investigated (P>0.05). Our findings suggested that an increase in GPC6 expression levels may be implicated in gastric cancer development, but not in cancer progression.
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May-2015
Volume 3 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

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Spandidos Publications style
Dinccelik‑Aslan M, Gumus‑Akay G, Elhan AH, Unal E and Tukun A: Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma. Mol Clin Oncol 3: 584-590, 2015
APA
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A.H., Unal, E., & Tukun, A. (2015). Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma. Molecular and Clinical Oncology, 3, 584-590. https://doi.org/10.3892/mco.2015.486
MLA
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A. H., Unal, E., Tukun, A."Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma". Molecular and Clinical Oncology 3.3 (2015): 584-590.
Chicago
Dinccelik‑Aslan, M., Gumus‑Akay, G., Elhan, A. H., Unal, E., Tukun, A."Diagnostic and prognostic significance of glypican 5 and glypican 6 gene expression levels in gastric adenocarcinoma". Molecular and Clinical Oncology 3, no. 3 (2015): 584-590. https://doi.org/10.3892/mco.2015.486