search button
Open Access

Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection

  • Authors:
    • Bo Zhang
    • Dan Wang
    • Yunbao Guo
    • Jinlu Yu

  • View Affiliations

  • Published online on: January 22, 2015     https://doi.org/10.3892/mco.2015.493
  • Pages: 501-505

  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The aim of the present study was to identify the major factors correlated with early postoperative seizures in elderly patients who had undergone a meningioma resection, and subsequently, to develop a logistic regression equation for assessing the seizures risk. Fourteen factors possibly correlated with early postoperative seizures in a cohort of 209 elderly patients who had undergone meningioma resection, as analyzed by multifactorial stepwise logistic regression. Phenobarbital sodium (0.1 g, intramuscularly) was administered to all 209 patients 30 min prior to undergoing surgery. All the patients had no previous history of seizures. The correlation of the 14 clinical factors (gender, tumor site, dyskinesia, peritumoral brain edema (PTBE), tumor diameter, pre‑ and postoperative prophylaxes, surgery time, tumor adhesion, circumscription, blood supply, intraoperative transfusion, original site of the tumor and dysphasia) was assessed in association with the risk for post‑operative seizures. Tumor diameter, postoperative prophylactic antiepileptic drug (PPAD) administration, PTBE and tumor site were entered as risk factors into a mathematical regression model. The odds ratio (OR) of the tumor diameter was >1, and PPAD administration showed an OR >1, relative to a non‑prophylactic group. A logistic regression equation was obtained and the sensitivity, specificity and misdiagnosis rates were 91.4, 74.3 and 25.7%, respectively. Tumor diameter, PPAD administration, PTBE and tumor site were closely correlated with early postoperative seizures; PTBE and PPAD administration were risk and protective factors, respectively.
View References

Related Articles

Journal Cover

May-2015
Volume 3 Issue 3

Print ISSN: 2049-9450
Online ISSN:2049-9469

Sign up for eToc alerts

Recommend to Library

  • Journal Metrics
  • Impact Factor: 1.2
  • Ranked
    (total number of cites)
  • CiteScore: 2.6
  • CiteScore Rank: Q3: #242/366 Oncology
  • Source Normalized Impact per Paper (SNIP): 0.693
  • SCImago Journal Rank (SJR): 0.393
International Symposium on Molecular Medicine Conference Banner
The Cancer Story
World Congress on Advances in Oncology and International Symposium on Molecular Medicine Conference Banner
World Academy Of Sciences Banner
Heyday Road Banner

0

Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, Wang D, Guo Y and Yu J: Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Mol Clin Oncol 3: 501-505, 2015
APA
Zhang, B., Wang, D., Guo, Y., & Yu, J. (2015). Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection. Molecular and Clinical Oncology, 3, 501-505. https://doi.org/10.3892/mco.2015.493
MLA
Zhang, B., Wang, D., Guo, Y., Yu, J."Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection". Molecular and Clinical Oncology 3.3 (2015): 501-505.
Chicago
Zhang, B., Wang, D., Guo, Y., Yu, J."Clinical multifactorial analysis of early postoperative seizures in elderly patients following meningioma resection". Molecular and Clinical Oncology 3, no. 3 (2015): 501-505. https://doi.org/10.3892/mco.2015.493