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Review

CKS2 in human cancers: Clinical roles and current perspectives (Review)

  • Authors:
    • Hanyu You
    • Huayue Lin
    • Zhongying Zhang
  • View Affiliations / Copyright

    Affiliations: Center for Clinical Laboratory, Xiamen University Affiliated Zhongshan Hospital, Xiamen, Fujian 361000, P.R. China
  • Pages: 459-463
    |
    Published online on: February 4, 2015
       https://doi.org/10.3892/mco.2015.501
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Abstract

Cyclin‑dependent kinase subunit 2 (CKS2) is indicated in the processes of cell cycle and cell proliferation. Through these processes, CKS2 is identified as a cancer gene, but its role has not been well reviewed. The aim of the present study was to summarize the clinicopathological significance and the molecular mechanisms of CKS2 in human cancers. Its expression was upregulated in the majority of the types of cancer studied. CKS2 was shown to have a function in cancers of the digestive tract, genital tract, thyroid, nerve and certain other types of cancer. CKS2 can promote progression of certain cancers via positive control of proliferation, invasion and migration. Downregulation of CKS2 induces cancer cell apoptosis. CKS2 can change a multitude of cellular mechanisms in cancer pathogenesis by regulating the gene translation of numerous validated targets, such as p53, CDK1, cyclin A, cyclin B1, caspase‑3 and Bax. In addition, the molecular mechanism that causes aberrant expression of CKS2 was epigenetic modification of miR‑26a and the Y‑box‑binding protein 1 (YB‑1) gene. In conclusion, CKS2 is commonly elevated in cancer, most likely due to its ability to promote cancer cell growth, invasion and migration through regulating certain significant genes. Understanding the mechanisms by which CKS2 is involved with cancer pathogenesis will be useful in the development of tumor therapy for patients with cancer.
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Copy and paste a formatted citation
Spandidos Publications style
You H, Lin H and Zhang Z: CKS2 in human cancers: Clinical roles and current perspectives (Review). Mol Clin Oncol 3: 459-463, 2015.
APA
You, H., Lin, H., & Zhang, Z. (2015). CKS2 in human cancers: Clinical roles and current perspectives (Review). Molecular and Clinical Oncology, 3, 459-463. https://doi.org/10.3892/mco.2015.501
MLA
You, H., Lin, H., Zhang, Z."CKS2 in human cancers: Clinical roles and current perspectives (Review)". Molecular and Clinical Oncology 3.3 (2015): 459-463.
Chicago
You, H., Lin, H., Zhang, Z."CKS2 in human cancers: Clinical roles and current perspectives (Review)". Molecular and Clinical Oncology 3, no. 3 (2015): 459-463. https://doi.org/10.3892/mco.2015.501
Copy and paste a formatted citation
x
Spandidos Publications style
You H, Lin H and Zhang Z: CKS2 in human cancers: Clinical roles and current perspectives (Review). Mol Clin Oncol 3: 459-463, 2015.
APA
You, H., Lin, H., & Zhang, Z. (2015). CKS2 in human cancers: Clinical roles and current perspectives (Review). Molecular and Clinical Oncology, 3, 459-463. https://doi.org/10.3892/mco.2015.501
MLA
You, H., Lin, H., Zhang, Z."CKS2 in human cancers: Clinical roles and current perspectives (Review)". Molecular and Clinical Oncology 3.3 (2015): 459-463.
Chicago
You, H., Lin, H., Zhang, Z."CKS2 in human cancers: Clinical roles and current perspectives (Review)". Molecular and Clinical Oncology 3, no. 3 (2015): 459-463. https://doi.org/10.3892/mco.2015.501
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