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miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma

  • Authors:
    • Ryota Mukai
    • Yoshito Tomimaru
    • Hiroaki Nagano
    • Hidetoshi Eguchi
    • Koshi Mimori
    • Akira Tomokuni
    • Tadafumi Asaoka
    • Hiroshi Wada
    • Koichi Kawamoto
    • Shigeru Marubashi
    • Yuichiro Doki
    • Masaki Mori
  • View Affiliations / Copyright

    Affiliations: Department of Surgery, Graduate School of Medicine, Osaka University, Suita, Osaka 565‑0871, Japan, Department of Surgery, Kyushu University Beppu Hospital, Beppu, Oita 874‑0838, Japan
    Copyright: © Mukai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 487-494
    |
    Published online on: February 25, 2015
       https://doi.org/10.3892/mco.2015.514
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Abstract

The significance of disseminated tumor cells (DTCs) in bone marrow (BM) on tumor recurrence has not been investigated in patients with hepatocellular carcinoma (HCC). The aim of the present study was to clarify the molecular characteristics of DTCs that affect postoperative recurrence based on microRNA (miRNA) expression profiles in clinical HCC patients undergoing curative resection. DTCs were prospectively collected from the BM of preoperative HCC patients using immunomagnetic beads and subjected to miRNA microarray analysis. Microarray analysis of nine HCC patients (n=5 patients with postoperative HCC recurrence, n=4 patients without HCC recurrence) demonstrated that miR‑615‑3p is significantly upregulated in the DTCs of patients with recurrence compared to the DTCs from patients without recurrence. In vitro experiments demonstrated that the miR‑615‑3p expression level is significantly correlated with malignant characteristics in HCC cells. These data suggest that miR‑615‑3p in DTCs may play an important role in postoperative HCC recurrence, which suggests that miR‑615‑3p is a potential target molecule for regulating postoperative HCC recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Mukai R, Tomimaru Y, Nagano H, Eguchi H, Mimori K, Tomokuni A, Asaoka T, Wada H, Kawamoto K, Marubashi S, Marubashi S, et al: miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma. Mol Clin Oncol 3: 487-494, 2015.
APA
Mukai, R., Tomimaru, Y., Nagano, H., Eguchi, H., Mimori, K., Tomokuni, A. ... Mori, M. (2015). miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma. Molecular and Clinical Oncology, 3, 487-494. https://doi.org/10.3892/mco.2015.514
MLA
Mukai, R., Tomimaru, Y., Nagano, H., Eguchi, H., Mimori, K., Tomokuni, A., Asaoka, T., Wada, H., Kawamoto, K., Marubashi, S., Doki, Y., Mori, M."miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma". Molecular and Clinical Oncology 3.3 (2015): 487-494.
Chicago
Mukai, R., Tomimaru, Y., Nagano, H., Eguchi, H., Mimori, K., Tomokuni, A., Asaoka, T., Wada, H., Kawamoto, K., Marubashi, S., Doki, Y., Mori, M."miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma". Molecular and Clinical Oncology 3, no. 3 (2015): 487-494. https://doi.org/10.3892/mco.2015.514
Copy and paste a formatted citation
x
Spandidos Publications style
Mukai R, Tomimaru Y, Nagano H, Eguchi H, Mimori K, Tomokuni A, Asaoka T, Wada H, Kawamoto K, Marubashi S, Marubashi S, et al: miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma. Mol Clin Oncol 3: 487-494, 2015.
APA
Mukai, R., Tomimaru, Y., Nagano, H., Eguchi, H., Mimori, K., Tomokuni, A. ... Mori, M. (2015). miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma. Molecular and Clinical Oncology, 3, 487-494. https://doi.org/10.3892/mco.2015.514
MLA
Mukai, R., Tomimaru, Y., Nagano, H., Eguchi, H., Mimori, K., Tomokuni, A., Asaoka, T., Wada, H., Kawamoto, K., Marubashi, S., Doki, Y., Mori, M."miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma". Molecular and Clinical Oncology 3.3 (2015): 487-494.
Chicago
Mukai, R., Tomimaru, Y., Nagano, H., Eguchi, H., Mimori, K., Tomokuni, A., Asaoka, T., Wada, H., Kawamoto, K., Marubashi, S., Doki, Y., Mori, M."miR-615-3p expression level in bone marrow is associated with tumor recurrence in hepatocellular carcinoma". Molecular and Clinical Oncology 3, no. 3 (2015): 487-494. https://doi.org/10.3892/mco.2015.514
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