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Article

Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer

  • Authors:
    • Yasemin Kemal
    • Guzin Demirag
    • Kubilay Ekiz
    • Idris Yucel
  • View Affiliations / Copyright

    Affiliations: Department of Medical Oncology, Faculty of Medicine, Ondokuz Mayis University, Samsun 55139, Turkey, Department of Internal Medicine, Faculty of Medicine, Ondokuz Mayis University, Samsun 55139, Turkey
  • Pages: 629-632
    |
    Published online on: March 2, 2015
       https://doi.org/10.3892/mco.2015.521
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Abstract

Thyroid extracts were first used to treat patients with metastatic breast cancer over a century ago. Since then, a number of studies have investigated the association between thyroid disorders and breast cancer. the presence of antibodies to thyroid peroxidase (TPOab) was recently reported to be associated with improved outcome in these patients. The aim of the present study was to evaluate the association between TPOab positivity and clinicopathological characteristics in breast cancer patients. The study included 318 newly diagnosed cases of breast cancer treated at Ondokuz Mayis University Hospital, Samsun, Turkey, between 2008 and 2012. Serum thyroid‑stimulating hormone, free triiodothyronine and free thyroxine levels were measured at the time of diagnosis. Of the 318 patients, 253 were considered to be TPOab‑negative (TPOab ≤34 IU/ml) and 65 TPOab‑positive (TPOab >34 IU/ml). No cases with distant metastases were found in the TPOab‑positive group. However, 20 (7.9%) of the 253 patients displayed distant metastases in the TPOab‑negative group (P=0.01). Therefore, TPOab positivity was found to be associated with a lower incidence of metastasis in breast cancer patients.
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1 

Beatson GT: On the treatment of inoperable cases of carcinoma of the mamma: suggestions for a new method of treatment, with illustrative cases. Lancet. 2:104–107. 1986.

2 

Altieri A, Tavani A, Gallus S, Bosetti C, Talamini R, Franceschi S, Levi F and La Vecchia C: Correspondence re: Simon et al.Do thyroid disorders increase the risk of breast cancer? Cancer Epidemiol Biomarkers Prev. 12:684–686. 2003.PubMed/NCBI

3 

Ito K and Maruchi N: Breast cancer in patients with Hashimoto's thyroiditis. Lancet. 2:1119–1121. 1975. View Article : Google Scholar : PubMed/NCBI

4 

Rasmusson B, Feldt-Rasmussen U, Hegedüs L, Perrild H, Bech K and Høier-Madsen M: Thyroid function in patients with breast cancer. Eur J Cancer Clin Oncol. 23:553–556. 1987. View Article : Google Scholar : PubMed/NCBI

5 

Shering SG, Zbar AP, Moriarty M, McDermott EW, O'Higgins NJ and Smyth PP: Thyroid disorders and breast cancer. Eur J Cancer Prev. 5:504–506. 1996.PubMed/NCBI

6 

Maruchi N, Annegers JF and Kurland LT: Hashimoto's thyroiditis and breast cancer. Mayo Clin Proc. 51:263–265. 1976.PubMed/NCBI

7 

Anker GB, Lønning PE, Aakvaag A and Lien EA: Thyroid function in postmenopausal breast cancer patients treated with tamoxifen. Scand J Clin Lab Invest. 58:103–107. 1998. View Article : Google Scholar : PubMed/NCBI

8 

Kurland LT and Annegers JF: Letter: Breast cancer and Hashimoto's thyroiditis. Lancet. 1:8081976. View Article : Google Scholar : PubMed/NCBI

9 

Nogueira CR and Brentani MM: Triiodothyronine mimics the effect of estrogen in breast cancer cell lines. J Steroid Biochem Mol Biol. 59:271–279. 1996. View Article : Google Scholar : PubMed/NCBI

10 

Dinda S, Sanchez A and Moudgil V: Estrogen-like effects of thyroid hormone on the regulation of tumor suppressor proteins, p53 and retinoblastoma, in breast cancer cells. Oncogene. 21:761–768. 2002. View Article : Google Scholar : PubMed/NCBI

11 

Vonderhaar BK and Greco AE: Lobulo-alveolar development of mouse mammary glands is regulated by thyroid hormones. Endocrinology. 104:409–418. 1979. View Article : Google Scholar : PubMed/NCBI

12 

Mittra I, Perrin J and Kumaoka S: Thyroid and other autoantibodies in British and Japanese women: an epidemiological study of breast cancer. Br Med J. 1:257–259. 1976. View Article : Google Scholar : PubMed/NCBI

13 

Zophel K, Roggenbuck D and Schott M: Clinical review about TRAb assay's history. Autoimmun Rev. 9:695–700. 2010. View Article : Google Scholar : PubMed/NCBI

14 

McLachlan SM and Rapoport B: The molecular biology of thyroid peroxidase: cloning, expression, and role as autoantigen in autoimmune thyroid disease. Endocr Rev. 13:192–206. 1992. View Article : Google Scholar : PubMed/NCBI

15 

Khoury EL, Hammond L, Bottazzo GF and Doniach D: Presence of the organ-specific ‘microsomal’ autoantigen on the surface of human thyroid cells in culture: its involvement in complement-mediated cytotoxicity. Clin Exp Immunol. 45:316–328. 1981.PubMed/NCBI

16 

Mariotti S, Caturegli P, Piccolo P, Barbesino G and Pinchera A: Antithyroid peroxidase autoantibodies in thyroid diseases. J Clin Endocrinol Metab. 71:661–669. 1990. View Article : Google Scholar : PubMed/NCBI

17 

Feldt-Rasmussen U, Høier-Madsen M, Bech K, et al: Anti-thyroid peroxidase antibodies in thyroid disorders and non-thyroid autoimmune diseases. Autoimmunity. 9:245–254. 1991. View Article : Google Scholar : PubMed/NCBI

18 

Gogas J, Kouskos E, Tseleni-Balafouta S, Markopoulos C, Revenas K, Gogas G and Kostakis A: Autoimmune thyroid disease in women with breast carcinoma. Eur J Surg Oncol. 27:626–630. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Myhill J, Reeve TS and Hales IB: Thyroid function in breast cancer. Acta Endocrinol (Copenh). 51:290–300. 1996.

20 

Giani C, Fierabracci P, Bonnaci R, et al: Relationship between breast cancer and thyroid disease: relevance of autoimmune thyroid disorders in breast malignancy. J Clin Endocrinol Metab. 81:990–994. 1996. View Article : Google Scholar : PubMed/NCBI

21 

Smyth PP: Autoimmune thyroid disease and breast cancer: a chance association? J Endocrinol Invest. 23:42–43. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Sarlis NJ, Gourgiotis L, Pucino F and Tolis GJ: Lack of association between Hashimoto thyroiditis and breast cancer: a quantitative research synthesis. Hormones (Athens). 1:35–41. 2002. View Article : Google Scholar : PubMed/NCBI

23 

Simon MS, Tang MT, Bernstein L, et al: Do thyroid disorders increase the risk of breast cancer? Cancer Epidemiol Biomarkers Prev. 11:1574–1578. 2002.PubMed/NCBI

24 

Cristofanilli M, Yamamura Y, Kau SW, et al: Thyroid hormone and breast carcinoma. Primary hypothyroidism is associated with a reduced incidence of primary breast carcinoma. Cancer. 103:1122–1128. 2005. View Article : Google Scholar : PubMed/NCBI

25 

Farahati J, Roggenbuck D, Gilman E, Schütte M, Jagminaite E, Seyed Zakavi R, Löning T and Heissen E: Anti-thyroid peroxidase antibodies are associated with the absence of distant metastases in patients with newly diagnosed breast cancer. Clin Chem Lab Med. 50:709–714. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Prinzi N, Baldini E, Sorrenti S, et al: Prevalence of breast cancer in thyroid diseases: results of a cross-sectional study of 3,921 patients. Breast Cancer Res Treat. 144:683–688. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Rodien PM, Madec AM, Ruf J, et al: Antibody-dependent cell-mediated cytotoxicity in autoimmune thyroid disease: relationship to antithyroperoxidase antibodies. J Clin Endocrinol Metab. 81:2595–2600. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Bhattacharya A and Vonderhaar BK: Specific binding proteins for 3, 5, 30-triiodothyronine in mouse mammary epithelium. J Cell Biol. 75:47a1977.

29 

Selliti DF, Tseng YC and Latham KR: Nuclear thyroid hormone receptor in C3H/HeN mouse mammary glands and spontaneous tumors. Cancer Res. 43:1030–1038. 1983.PubMed/NCBI

30 

Smallridge RC and Latham KR: Nuclear thyroid hormone receptor in human breast tumors. Clin Res. 28:4211980.

31 

Cerbon MA, Pichon MF and Milgrom E: Thyroid hormone receptors in human breast cancer. Cancer Res. 41:4167–4173. 1981.PubMed/NCBI

32 

Spitzweg C, Joba W, Eisenmenger W and Heufelder AE: Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa. J Clin Endocrinol Metab. 83:1746–1751. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Kilbane MT, Ajjan RA, Weetman AP, Dwyer R, McDermott EW, O'Higgins NJ and Smyth PP: Tissue iodine content and serum-mediated 125I uptake-blocking activity in breast cancer. J Clin Endocrinol Metab. 85:1245–1250. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Stadel BV: Dietary iodine and risk of breast, endometrial, and ovarian cancer. Lancet. 1:890–891. 1976. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Kemal Y, Demirag G, Ekiz K and Yucel I: Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer. Mol Clin Oncol 3: 629-632, 2015.
APA
Kemal, Y., Demirag, G., Ekiz, K., & Yucel, I. (2015). Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer. Molecular and Clinical Oncology, 3, 629-632. https://doi.org/10.3892/mco.2015.521
MLA
Kemal, Y., Demirag, G., Ekiz, K., Yucel, I."Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer". Molecular and Clinical Oncology 3.3 (2015): 629-632.
Chicago
Kemal, Y., Demirag, G., Ekiz, K., Yucel, I."Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer". Molecular and Clinical Oncology 3, no. 3 (2015): 629-632. https://doi.org/10.3892/mco.2015.521
Copy and paste a formatted citation
x
Spandidos Publications style
Kemal Y, Demirag G, Ekiz K and Yucel I: Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer. Mol Clin Oncol 3: 629-632, 2015.
APA
Kemal, Y., Demirag, G., Ekiz, K., & Yucel, I. (2015). Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer. Molecular and Clinical Oncology, 3, 629-632. https://doi.org/10.3892/mco.2015.521
MLA
Kemal, Y., Demirag, G., Ekiz, K., Yucel, I."Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer". Molecular and Clinical Oncology 3.3 (2015): 629-632.
Chicago
Kemal, Y., Demirag, G., Ekiz, K., Yucel, I."Antithyroid peroxidase antibody positivity is associated with lower incidence of metastasis in breast cancer". Molecular and Clinical Oncology 3, no. 3 (2015): 629-632. https://doi.org/10.3892/mco.2015.521
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